Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition

A technology of glucose and application, applied in the application field of α-ketoglutarate for treating malnutrition or symptoms of high plasma glucose, can solve the problem of incomplete understanding of the mechanism of action and the like

Inactive Publication Date: 2008-11-12
ESSENTYS AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its mechanism of action is not fully understood (Pierzynowski, S.G., and Sjodin, A. (1998) J. Anim. a. Feed Sci. 7:79-91; and Pierzynowski S.G., et al. Eds: KBK Knutsen and J-E Lindberg. , Uppsala 19-21 June, 2001)

Method used

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  • Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition
  • Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition
  • Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0230] Example 1 - Measurement of plasma AKG, glucose, ammonia, blood flow and overall urea flow.

[0231] Purpose

[0232] The purpose of this example was to evaluate the effect of AKG infusion on plasma AKG, glucose, ammonia, blood flow and overall urea flow.

[0233] Animal experiment

[0234] Piglets were deprived of food for 15 hours before starting the experiment.

[0235] On the day of the experiment, at -1 hour, continuous duodenal infusion of a pre-prepared formula [Litter Life, Merrick, Middleton, WI; 7.75 mL / (kg h)] (7.75 mL / kg; 25% wt / wt water solution; oral administration), which is prepared as a 25% (wt / wt) water solution, it can provide about 920kJ and 12.5g protein / (kg d).

[0236] Saline (control; 930 mmol / L NaCl) or sodium-AKG (Na-AKG), 930 mmol / L, purchased from Sigma-Aldrich, St. Louis, MO) was dissolved in the formula.

[0237] Based on previous data (6), the AKG content was chosen by an outside laboratory where, in order to observe a detectable por...

example 3

[0279] Example 3 - Effects of Enterally Administered Na-AKG and Chitosan-AKG on Amino Acid and Keto Acid Absorption Receipt in enterocytes and plasma, and comparison of their metabolic effects

[0280] Purpose

[0281] The purpose of this example was to compare the effects of enterally administered Na-AKG (or Na salt of AKG) and chitosan-AKG on the absorption of amino acids and ketoacids into enterocytes and plasma and their metabolism. In addition, the effects of Na-AKG and chitosan-AKG on the conversion of ketoacids to amino acids were determined by monitoring blood plasma amino acid content. This study tested the hypothesis that AKG affects the intestinal conversion of ketoacids to amino acids and improves protein synthesis.

[0282] Animal experiment

[0283] A total of three pigs were used in this experiment. These pigs weighed approximately 20kg. The pigs were housed separately in boxes and fed a standard diet for 4-5 days to allow acclimatization to the new faci...

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PUM

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Abstract

The invention discloses a method for improving adsorption of amino acids in a vertebrate, including mammal and bird, as well as compositions for use in treatment. The method comprises administering to a vertebrate, including mammal and bird, in a sufficient amount and / or at a sufficient rate to enable desire effect. AKG, AKG derivatives or metabolites, AKG analogues or mixture thereof. Also conteplated is a method for decreasing adsorption of glucose in a vertebrate, including mammal and bird, in the need thereof, AKG, AKG derivates or metabolites, AKG analogues or mixture thereof, for decreasing glucose adsorption.

Description

[0001] This application is a divisional application with an application date of July 1, 2004, an application number of 200480020322.7, and the title of the invention is "Use of α-ketoglutaric acid for treating symptoms of malnutrition or high plasma glucose". technical field [0002] The present invention relates to methods for improving the absorption of amino acids in vertebrates, including mammals and birds, and methods for reducing glucose absorption. The invention also relates to the production of compositions for improving the absorption of amino acids in said vertebrates. Background of the invention [0003] Diabetes mellitus is a serious metabolic disease defined by the appearance of chronically elevated plasma glucose levels. Typical symptoms of diabetes in adults are polyuria, polydipsia, ketonuria, rapid weight loss, and higher levels of plasma glucose. [0004] Normal fasting plasma glucose concentration is less than 115 mg / dl per liter. In diabetic patients, f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P3/10A23L1/305A61K
CPCA61K31/19A61K31/722A61K31/198A61K31/401A23L1/3051A23L33/175
Inventor S·G·皮尔茨诺夫斯基D·布林
Owner ESSENTYS AB
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