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Senna formulation and quality control method

A quality control method and technology of senna, applied in the directions of pill delivery, pharmaceutical formulation, measuring device, etc., can solve the problems of low extraction rate, thermal instability of active ingredients, long heating time, etc.

Inactive Publication Date: 2008-12-24
何文健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditionally, decoction, soaking in boiling water, ethanol reflux, etc. are used to extract, concentrate, and dry to obtain the active ingredients of senna leaves, which have the problems of low proposing rate, long heating time, and loss of active ingredients due to thermal instability.

Method used

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  • Senna formulation and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 Granules

[0020] 【Prescription】Senna Leaf 2000g

[0021] [Preparation method] Get senna leaf coarse powder (20 mesh powder), according to the percolation method under the liquid extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix IO), make solvent ultrasonic with 30% ethanol three times amount After 30 minutes of treatment, carry out percolation, collect 8 times the amount of percolation liquid of medicinal materials, concentrate under low temperature and reduced pressure to a clear paste with a relative density of 1.24-1.28 (60°C) as a binder. According to the amount of total sennosides contained in the clear paste, add appropriate amount of dextrin and sucrose powder, boil and granulate, dry, pack, and make the total sennosides contained in granules of this product. , should be 40-50 mg, and made into 1000 bags of granules with a specification of 10 g per bag.

Embodiment 2

[0022] Example 2 tablet

[0023] 【Prescription】Senna Leaf 1000g

[0024] [Preparation method] Get senna leaf coarse powder (20 mesh powder), according to the percolation method under the liquid extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix IO), make solvent ultrasonic with 30% ethanol three times amount After 30 minutes of treatment, carry out percolation, collect 8 times the percolation liquid of the medicinal material, concentrate under low temperature and reduced pressure to a ointment with a relative density of 1.16-1.22 (60°C), spray dry (inlet air temperature 160-170°C, outlet air temperature 50~60℃) into extract powder. According to the amount of total sennosides contained in the clear ointment measured, add an appropriate amount of starch, add an appropriate amount of silicon dioxide, and press the powder into tablets to make the tablet of this product. Each tablet contains total sennosides in terms of sennoside B, which should be 20-25 mg...

Embodiment 3

[0025] Embodiment 3 capsules

[0026] [Prescription] Senna 1000g

[0027] [Preparation method] Get senna leaf coarse powder (20 mesh powder), according to the percolation method under the liquid extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix IO), make solvent ultrasonic with 30% ethanol three times amount After 30 minutes of treatment, carry out percolation, collect 8 times the percolation liquid of the medicinal material, concentrate under low temperature and reduced pressure to a ointment with a relative density of 1.16-1.22 (60°C), spray dry (inlet air temperature 160-170°C, outlet air temperature 50~60℃) into extract powder. According to the amount of total sennosides contained in the clear ointment, add appropriate amount of starch, granulate, dry, add appropriate amount of silicon dioxide, and fill capsules to make capsules of this product. Each capsule contains total sennosides and sennoside B Calculated, should be 20 ~ 25mg, made into 1000 ...

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Abstract

The invention relates to a senna leaf preparation and a quality control method. The senna leaf has the pharmacological effects of lapactic, anti-bacterium, hemostasis, spasmolysis, etc. The preparation is mainly used for cleaning preparation of intestinal canal before each image detection or operation for abdomen and intestinal canal, mainly treats constipation, particularly the constipation of the old people and the intractable constipation, and has promotion founction for intestinal function recovery after the abdomen operation. In the past, the senna leaf is drunk by a method of making in boiling water, the dissolvable amount of the active component sennoside of the senna leaf is unstable, and the useful effect is affected greatly. The aim of the invention is to prepare the active component preparation of the senna leaf with stable content, the used dosage is accurate, and the effect is stable. Meanwhile, the invention provides a lamella identifying and content measuring method.

Description

technical field [0001] The invention relates to a preparation process and a quality control method of a medicine, in particular to a senna leaf preparation and a quality control method. Background technique [0002] Senna leaves are the dried leaflets of Cassia angustifolia Vahl and Cassia acutifolia Delile, a leguminous herbaceous plant. Traditional Chinese medicine believes that this product is cold in nature, sweet and bitter in taste, and belongs to the large intestine meridian. It has the effects of purging heat and stagnation, laxative and diuresis. Modern studies have found that senna has pharmacological effects such as diarrhea, antibacterial, hemostasis, and antispasmodic. It is mainly used for intestinal cleaning preparation before various imaging examinations of the abdomen and intestinal tract or before surgery, and it is mainly used to treat various constipation, especially elderly Sexual and obstinate constipation; It also has a promoting effect on the recove...

Claims

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Application Information

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IPC IPC(8): A61K36/482A61K9/20A61K9/16A61K9/48A61K9/46G01N30/02G01N30/90A61P1/10A61K127/00
Inventor 王世锋
Owner 何文健
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