Medicinal fine pellet core and preparation method

Abstract

A medical pellet core comprises main materials of medical starch and bond, sucrose syrup and purified water. The components are 50 percent to 72 percent of medical starch, 25 percent to 45 percent of sucrose and water of rest. The preparation method of the medical pellet core has the steps that 1) sucrose preparation: the sucrose is put in a container which water is added in, is heat to be meltedand is filtered and cooled for using; 2) pellet preparation: the starch is put into a pelletizer, the pelletizer is started, and the rotate speed of the main machine of the pelletizer is adjusted to 25r to 30r per minute; the rotate speed of a peristaltic pump is adjusted to 60r to 108r per minute; the starch is added while the syrup is sprayed, and the pellet cores come out of a pot; 3) drying: the obtained pellet cores in the step 2) are put into a drying device for drying, and then the dry pellet cores are obtained; 4) screening and package: the dried pellet cores are cooled to 40 DEG C to60 DEG C, then are screened to obtained the pellet cores with different sizes and are packaged separately. The pellet core preparation needs less equipment, has simple process, high finished product rate, less waste in preparation and stable product quality.

Description

Technical field

[0001] The invention relates to the field of pharmacy, in particular to a preparation method of medicinal pellet cores. Background technique

[0002] In terms of technology, medicinal pellets are characterized by uniform particle size, firmness, round surface, easy coating and thickness of the coating layer to control the release rate; solve the contraindications of drug compatibility and improve drug stability; coating different types of coating layers , Make preparations (rapid release, positioning or slow / controlled release) needed for clinical treatment. In terms of pharmacodynamics, it is characterized by being less affected by the rhythm of food delivery and uniform drug absorption; it is a multi-dose drug preparation with low irritation and good blood drug reproducibility between doses; drug particles are evenly distributed on the surface of the intestinal mucosa , Good bioavailability. Therefore, the application of medicinal pellets is more and more exte...