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Medicinal fine pellet core and preparation method

A technology for pellet cores and pellets, which is applied in the field of preparation of medicinal pellet cores, can solve problems such as easy breakage and brittle particle texture, and achieve the effects of increasing drying capacity, small use area and reducing environmental pressure.

Active Publication Date: 2010-08-18
药大制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The ball core only uses starch as the main material, which solves the problem of brittle and easily broken particles caused by mixing sucrose fine powder as the main material in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0030] Prescription: 50kg of sucrose, 100kg of starch, the balance is purified water

[0031] Preparation process:

[0032] 1) Configure syrup: Take sucrose and put it in the reaction pot, add an appropriate amount of purified water, and open the steam regulating valve to keep the steam pressure at 0.15MPa. After boiling until the sugar is completely dissolved, keep boiling for 18 minutes, and turn off the steam control valve. After the syrup is cooled to about 80°C, it is passed through a 100-mesh sieve and cooled for later use. A syrup with a concentration of about 50% is obtained.

[0033] 2) Masterbatch: Pour 5-8Kg of starch into the coating granulator, turn on the power, exhaust fan, blower, and host in turn, and adjust the host speed to 30 rpm. Adjust the rotation speed of the peristaltic pump to 100 rpm and the air source pressure to 0.6Mpa. While spraying the syrup, add a small amount of starch, and take it out of the pot after it becomes pellets.

[0034] 3) Pill-making c...

example 2

[0041] Recipe: 35 kg of sucrose, 100 kg of starch, the balance is purified water, and the fluidized bed is used for drying. The specific steps are as follows:

[0042] 1) Configure syrup: Take sucrose and put it in the reaction pot, add an appropriate amount of purified water, and open the steam control valve to keep the steam pressure at 0.1MPa. After boiling until the sugar is completely dissolved, keep boiling for 20 minutes, and turn off the steam control valve. After the syrup is cooled to about 60°C, pass through a 90-mesh sieve and cool for later use. A syrup with a concentration of about 50% is obtained.

[0043] 2) Masterbatch: Pour 5-8Kg of starch into the coating granulator, turn on the power, exhaust fan, blower, and host in turn, and adjust the host speed to 35 rpm. Adjust the speed of the peristaltic pump to 170 rpm and the air source pressure to 0.6Mpa. While spraying the syrup, add a small amount of starch, and take it out of the pot after it becomes pellets.

[0...

example 3

[0048] Prescription: 80kg of sucrose, 100kg of starch, the balance is purified water

[0049] Preparation process:

[0050] 1) Configure syrup: take sucrose and put it in the reaction pot, add purified water, open the steam control valve to keep the steam pressure at 0.2MPa. After boiling until the sugar is completely dissolved, keep boiling for 16 minutes, and turn off the steam control valve. After the syrup is cooled to about 80°C, pass through a 120-mesh sieve and cool for later use. A syrup with a concentration of about 50% is obtained.

[0051] 2) Masterbatch: Pour 5-8Kg of starch into the coating granulator, turn on the power, exhaust fan, blower, and host in turn, and adjust the host speed to 90rpm. Adjust the rotation speed of the peristaltic pump to 140 rpm and the air source pressure to 0.55Mpa. While spraying the syrup, add a small amount of starch, and take it out of the pot after it becomes pellets.

[0052] 3) Pill-making core: Pour the masterbatch into the coating ...

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Abstract

A medical pellet core comprises main materials of medical starch and bond, sucrose syrup and purified water. The components are 50 percent to 72 percent of medical starch, 25 percent to 45 percent of sucrose and water of rest. The preparation method of the medical pellet core has the steps that 1) sucrose preparation: the sucrose is put in a container which water is added in, is heat to be meltedand is filtered and cooled for using; 2) pellet preparation: the starch is put into a pelletizer, the pelletizer is started, and the rotate speed of the main machine of the pelletizer is adjusted to 25r to 30r per minute; the rotate speed of a peristaltic pump is adjusted to 60r to 108r per minute; the starch is added while the syrup is sprayed, and the pellet cores come out of a pot; 3) drying: the obtained pellet cores in the step 2) are put into a drying device for drying, and then the dry pellet cores are obtained; 4) screening and package: the dried pellet cores are cooled to 40 DEG C to60 DEG C, then are screened to obtained the pellet cores with different sizes and are packaged separately. The pellet core preparation needs less equipment, has simple process, high finished product rate, less waste in preparation and stable product quality.

Description

Technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation method of medicinal pellet cores. Background technique [0002] In terms of technology, medicinal pellets are characterized by uniform particle size, firmness, round surface, easy coating and thickness of the coating layer to control the release rate; solve the contraindications of drug compatibility and improve drug stability; coating different types of coating layers , Make preparations (rapid release, positioning or slow / controlled release) needed for clinical treatment. In terms of pharmacodynamics, it is characterized by being less affected by the rhythm of food delivery and uniform drug absorption; it is a multi-dose drug preparation with low irritation and good blood drug reproducibility between doses; drug particles are evenly distributed on the surface of the intestinal mucosa , Good bioavailability. Therefore, the application of medicinal pellets is more and more exte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/00A61K47/36A61K9/16
Inventor 倪滨斌倪冲沈涛沈彬沈力
Owner 药大制药有限公司
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