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Instant jelly glue of carbomer for eyes

A carbomer eye and gel technology, which is applied in the field of medicine, can solve the problems of large loss of eye drops, short residence time, and restrictions on the curative effect of carbomer eye drops, etc., so as to prolong the residence time, improve the curative effect, enrich the The effect of the drug dosage form

Inactive Publication Date: 2009-01-14
肖正连
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Carbomer eye drops is a relatively commonly used ophthalmic preparation, but clinically there is a large loss of eye drops instilled into the eye and a short residence time. These problems limit the curative effect of carbomer eye drops and the wider use

Method used

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  • Instant jelly glue of carbomer for eyes
  • Instant jelly glue of carbomer for eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription: Carbomer 940 10g Hydrochloric acid (0.05mol / L) 400ml Sodium citrate 9.6g

[0030] Methylcellulose 5.0g Phenylethyl alcohol 0.5g Ethanol 5ml

[0031] Sodium Chloride 1.0g PEG-1000 20g

[0032] PEG-400 5g water for injection appropriate amount

[0033] Preparation method: Heat water for injection to boil, cool to 80°C, add Carbomer 940, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add hydrochloric acid After stirring, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while hot, and stir to room temperature (18-25°C ), add water for injection to make up the weight to 1000 milliliters, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 2

[0035] Prescription: Carbomer 940 10g Sulfuric acid (0.05mol / L) 200ml

[0036] Sodium Citrate 8.8g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0037] Ethanol 5ml Sodium Chloride 2.0g PEG-1000 70g

[0038] Appropriate amount of water for injection

[0039] Preparation method: heat water for injection to boil, cool to 80°C, add carbomer 940, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add sulfuric acid After stirring, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), and add Make up the weight with water for injection to 1000 ml, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 3

[0041] Prescription: Carbomer 940 10g Sodium Hydroxide (0.1mol / L) 200ml

[0042] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0043] Ethanol 5ml Sodium Chloride 5.0g PEG-4000 100g

[0044] Appropriate amount of water for injection

[0045] Preparation method: heat water for injection to boil, cool to 80°C, add Carbomer 940, add sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane (0.22 μm), the filtrate was heated to 40°C, PEG-4000 and methylcellulose were added while it was hot, stirred to room temperature (18-25°C), and water for injection was added to make up the weight to 1000 ml, and stirred to form a uniform Gel, aseptically dispensed.

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Abstract

The present invention discloses a Carbomer in-situ-forming ophthalmic gel and a preparation method thereof. 1000g of the Carbomer in-situ-forming ophthalmic gel of the present invention contains 10g to 40g of Carbomer, 0.05g to 1g of preservative, 1.0g to 7.5g of osmo-regulator and 30g to 150g of gel matrix, and the rest substances are acid buffer, alkali buffer and water for injection. By optimizing the auxiliary materials and improving the technique, the present invention enriches the pharmaceutical dosage forms of Carbomer, greatly prolongs the residence time of the drug in the eyes and improves the curative effect, and moreover, the Carbomer in-situ-forming ophthalmic gel does not generate any untoward irritation reaction.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and in particular relates to a carbomer ophthalmic instant gel. 【Background technique】 [0002] Ophthalmic instant gel is also called ophthalmic in-situ gel or ophthalmic in-situ gel. Its preparation is liquid when placed at room temperature. Gel-like, it can stay in the eye for a long time, so as to prolong the treatment time, enhance the treatment effect and reduce the loss of medicine. [0003] Instant ophthalmic gel is not yet a very mature pharmaceutical preparation, and instant ophthalmic gel, which depends on the principles of temperature, pH value and ionic strength, is not yet mature in commercialization, because the dosage form is not only It requires fine technology, appropriate excipients, and the proper matching of drugs, processes and excipients in ophthalmic ready-to-use gels. Otherwise, it cannot be placed in a liquid state at room temperature, and it will be transformed into ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/34A61K47/38A61K9/00A61P27/02A61K47/10
Inventor 肖正连
Owner 肖正连