Alficetin in situ forming eye gel

A chloramphenicol and gel technology, which is applied in the field of chloramphenicol ophthalmic ready-to-use gel, can solve the problems of large loss of eye drops, short retention time, and limit the wide use of chloramphenicol eye drops for curative effect. Adverse reactions, prolonging residence time, relieving dry eye disease and foreign body sensation

Inactive Publication Date: 2009-01-28
肖正连
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chloramphenicol eye drops is a commonly used ophthalmic preparation, but clinically there is a large loss of eye drops in the eye, a short re

Method used

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  • Alficetin in situ forming eye gel
  • Alficetin in situ forming eye gel
  • Alficetin in situ forming eye gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: Chloramphenicol 25g Hydrochloric acid (0.05mol / L) 400ml

[0027] Sodium Citrate 8.7g Methylcellulose 5.0g Phenylethyl Alcohol 0.5g

[0028] Ethanol 5ml Sodium Chloride 1.0g PEG-1000 20g

[0029] PEG-400 5g water for injection appropriate amount

[0030] Preparation method: Heat water for injection to boil, cool to 80°C, add chloramphenicol, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add hydrochloric acid Stir, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while hot, stir to room temperature (18-25°C) , and add water for injection to make up the weight to 1000 ml, stir to form a uniform gel, and aseptically pack it.

Embodiment 2

[0032] Prescription: Chloramphenicol 25g Sulfuric acid (0.05mol / L) 200ml

[0033] Sodium Citrate 8.7g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0034] Ethanol 5ml Sodium Chloride 2.0g PEG-1000 70g

[0035] Appropriate amount of water for injection

[0036] Preparation method: Heat water for injection to boil, cool to 80°C, add chloramphenicol, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add Stir after sulfuric acid, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), and then Add water for injection to make up the weight to 1000 ml, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 3

[0038] Prescription: Chloramphenicol 5g Sodium Hydroxide (0.1mol / L) 200ml

[0039] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0040] Ethanol 5ml Sodium Chloride 5.0g PEG-4000 100g

[0041] Appropriate amount of water for injection

[0042] Preparation method: heat and boil water for injection, cool to 80°C, add chloramphenicol, sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane (0.22 μm), the filtrate was heated to 40°C, PEG-4000 and methylcellulose were added while it was hot, stirred to room temperature (18-25°C), and water for injection was added to make up the weight to 1000 ml, and stirred to form a uniform Gel, aseptically dispensed.

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Abstract

The invention discloses a chloramphenicol eye ophthalmic gel and a preparation method thereof; every 1000ml of the chloramphenicol eye ophthalmic gel contains 5-50g of chloramphenicol, 0.05-1g of preservative, 1.0-7.5g of osmoregulation agent, 30-150g of gel stroma, and rest amount of acid-base buffering agent and water used for injection. Due to the optimization and technique improvement of the auxiliary materials, the medicine dosage forms of the chloramphenicol are enriched, detention time of the medicine in the eyes are greatly prolonged, and the medicine can exert the drug effect, thus not only improving healing efficacy, but also reducing the times and days for taking medicine, decreasing the part side effect of the medicine and the untoward effect caused by the whole body absorption, as well as having no pessimal stimulation response.

Description

【Technical field】 [0001] The invention belongs to the technical field of chemical medicines, and in particular relates to a chloramphenicol instant ophthalmic gel. 【Background technique】 [0002] Ophthalmic instant gel is also called ophthalmic in-situ gel or ophthalmic in-situ gel. Its preparation is liquid when placed at room temperature. Gel-like, it can stay in the eye for a long time, so as to prolong the treatment time, enhance the treatment effect and reduce the loss of medicine. [0003] Instant ophthalmic gel is not yet a very mature pharmaceutical preparation, and instant ophthalmic gel, which depends on the principles of temperature, pH value and ionic strength, is not yet mature in commercialization, because the dosage form is not only It requires fine technology, appropriate excipients, and the proper matching of drugs, processes and excipients in ophthalmic ready-to-use gels. Otherwise, it cannot be placed in a liquid state at room temperature, and it will be ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/165A61P27/02
Inventor 肖正连
Owner 肖正连
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