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Device for preparing particulates using supercritical fluid assistant spray and use thereof

A supercritical fluid and particle manufacturing technology, which is applied in the direction of microsphere preparation, liquid separation into beads and granulation, microcapsule preparation, etc., can solve the problems of non-drug-loaded particle research, particle collection and solvent exclusion, etc. , to achieve the effect of convenient preparation and collection, and reducing particle size changes

Inactive Publication Date: 2009-02-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method is currently mainly applied and experimentally studied. Under continuous preparation conditions, there is still no effective means for particle collection and solvent removal, and its application is mainly in the preparation of drug particles, and it has no effect on drug-loaded particles containing carriers. Deep research

Method used

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  • Device for preparing particulates using supercritical fluid assistant spray and use thereof
  • Device for preparing particulates using supercritical fluid assistant spray and use thereof
  • Device for preparing particulates using supercritical fluid assistant spray and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: supercritical fluid assisted spray manufacture particle equipment

[0017] see figure 1 , the supercritical fluid assisted spray production particle equipment consists of carbon dioxide storage tank 1, cooling water tank 2, valve 3, plunger pump 4, heater 5, gas-liquid mixing chamber 6, pressure monitoring 7, heating jacket 8, valve 9, nozzle base Seat 10, Drying Box 11, Valve 12, Constant Flow Pump 13, Solvent Storage Tank 14, Heating Mantle 15, Cyclone Separator 16, Collection Tank 17, Air Extractor 18, Air Heater 19, Supercritical Carbon Dioxide Storage Tank 20 , Air filter 21 and nozzle 22.

[0018] The carbon dioxide steel cylinder 1, the valve 3, the supercritical carbon dioxide storage tank 20, the plunger pump 4, and the gas-liquid mixing chamber 6 are connected by threads through pipelines, and the supercritical carbon dioxide storage tank 20 is placed in the cooling water tank 2, and the plunger pump 4 Part of the pipeline between the gas-liqui...

Embodiment 2

[0020] Example 2: Preparation of drug particles using supercritical fluid-assisted spray manufacturing particle equipment

[0021] Open exhaust fan 18, introduce air or nitrogen from air heater 19, form clean hot air (nitrogen) through filtration and heating, enter drying box 11, control the air inlet temperature of drying box 11 to be 80 ℃, weigh the drug Ni Modipine 1g, dissolved in 100ml of absolute ethanol, was added to the solvent storage tank 14, and the heating temperature of the solvent storage tank 14 was adjusted to 65°C, and was transported to the gas-liquid mixing chamber 6 by a constant flow pump 13 at a flow rate of 10ml / min ; After the liquid carbon dioxide is cooled, it is pressurized by the plunger pump 4, and after being heated to 65°C, it is sent into the gas-liquid mixing chamber 6 preheated to 65°C, and the delivery speed of carbon dioxide is controlled at 30ml / min respectively. When the pressure of the chamber 6 reaches 9Mpa, the valve 9 is opened, and th...

Embodiment 3

[0024] Example 3: Preparation of drug-loaded particles using supercritical fluid-assisted spray manufacturing particle equipment

[0025] Open the exhaust fan 18, introduce air or nitrogen from the air heater 19, form clean hot air (nitrogen) through filtration and heating, enter the drying oven 11, control the air inlet temperature of the drying oven 11 to be 80 ° C, weigh the stearin Acid 0.5g, dissolved in 100ml of absolute ethanol, added to the solvent storage tank 14, adjust the heating temperature of the solvent storage tank 14 to be 65 ° C, transported to the gas-liquid mixing chamber 6 by the constant flow pump 13, flow rate 10ml / min After the liquid carbon dioxide is cooled, it is pressurized by the plunger pump 4, and after being heated to 65°C, it is sent into the gas-liquid mixing chamber 6 preheated to 65°C, and the delivery speed of the carbon dioxide is controlled at 5, 10, 20, 30, 50ml / min. When the pressure of the gas-liquid mixing chamber 6 reaches 9Mpa, the...

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Abstract

The invention provides a device for producing microparticles by supercritical fluid auxiliary spray. The device consists of a carbon dioxide cylinder, a cooling water tank, a valve, a plunger pump, a heater, a gas-liquid mixing chamber, a pressure monitoring system, a heating jacket, a valve, a nozzle base, a drying box, a valve, a constant flow pump, a solvent storage tank, a heating jacket, a cyclone separator, a collection tank, an air pump, an air heater, a supercritical carbon dioxide storage tank, an air filter and a nozzle. The device provided by the invention can be applied to the preparation of pharmaceutical microparticles or nanoparticles, and drug-loaded microparticles or nanoparticles containing carriers. The device is characterized by reasonable design and low cost and adopts the integrated insulation design of the gas-liquid mixing chamber and the nozzle, which can reduce the nozzle temperature drop caused by the injection of the mixture of carbon dioxide and solvent, can ensure the spray to go smoothly; can decrease the change of particle sizes caused by temperature fluctuation, can continuously, efficiently and conveniently prepare and collect microparticles, and can be applicable to industrialized continuous production.

Description

technical field [0001] The invention belongs to the manufacturing equipment of pharmaceutical preparations, and mainly relates to the manufacture of a device for producing microparticles by supercritical fluid-assisted spraying, and a method for producing pharmaceutical microparticles by using the equipment. Background technique [0002] Micronization technology has always been an important process in the field of pharmaceutical preparations. The micronized drug can greatly increase the specific surface area of ​​the drug and improve the dissolution rate of the drug in body fluids, thereby significantly improving the bioavailability of the drug, reducing individual differences, and reducing side effects; the drug is wrapped in the carrier material. According to the properties of the materials used, the drug-loaded particles have the advantage of controlling drug release; and some submicron particles with a particle size of less than 1 micron also promote multiple functions s...

Claims

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Application Information

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IPC IPC(8): B01J2/02B01J13/04
Inventor 胡富强袁弘杜永忠
Owner ZHEJIANG UNIV
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