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Drug-loaded biodegradable shape memory macromolecule composite material and preparation method thereof

A polymer material and biodegradation technology, which is applied in the field of drug-loaded biodegradable shape memory polymer composite materials and its preparation, can solve the problems of inconvenient control of action time and dosage, additional oral administration or injection, and patient pain, etc. To achieve the effect of speeding up physical recovery, reducing pain and inconvenience, and reducing pain

Inactive Publication Date: 2009-02-11
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no drugs are implanted in the existing biodegradable shape memory polymer materials, and all therapeutic drugs need to be taken orally or injected, and some drugs need to be used for a long time, which brings great pain, inconvenience and trouble to patients; And its action time and dosage are often inconvenient to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A specific embodiment of the present invention is a preparation method of a drug-loaded biodegradable shape memory polymer composite:

[0015] Place 100 parts by weight of biodegradable polymer material polyε-caprolactone cross-linked in its organic solvent, methylene chloride, to form a gel system, and then disperse a drug solution containing 15 parts by weight of kanamycin in the gelatinized gel. In the glue system, a mixed system is obtained; vacuum-drying until no organic solvent is contained, the biodegradable polyε-caprolactone composite material loaded with medicine (anti-inflammatory drug-kanamycin) is obtained.

[0016] The complete degradation time of the polyε-caprolactone in this example is about 12 months. The UV-visible spectrophotometer test shows that the drug-loaded biodegradable cross-linked polyε-caprolactone gradually degrades in 12 months, and the drug is stable. , slow release, high release rate.

Embodiment 2

[0018] This example is basically the same as Example 1, except that the biodegradable polymer material is a copolymer of DL-lactic acid and L-lactic acid, and its organic solvent is acetone; the drug contained in the drug solution is 0.01 parts by weight of Antibiotic-streptomycin; the biodegradable poly DL-lactic acid and L-lactic acid composite material loaded with drug (streptomycin).

Embodiment 3

[0020] This example is basically the same as Example 1, except that the biodegradable polymer material is a polyglycol copolymer, and its organic solvent is methylene chloride; the drug contained in the drug solution is 25 parts by weight of hormone- Hydrocortisone; that is, a drug-loaded (hydrocortisone) biodegradable polyglycolic acid composite material.

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PUM

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Abstract

The invention discloses a biodegradable shape-memory polymer based composite material used for loading drugs, which comprises 100 portions of biodegradable polymer material and 0.01 to 25 portions of drugs, wherein, the drugs refer to one of or a mixture from more than one of antibiotics, hormone, a fibrous protein inhibitor, an anticoagulant, a calcium channel blocker, an antiphlogistic drug or a Chinese patent drug. The material not only has good properties of biodegradable shape-memory polymer material, but also is loaded with effective drug ingredients, thereby being capable of providing the function with controllable time of long-term and effective treatment for patients, quickening the physical rehabilitation of patients, reducing the drug dosage of the patients with oral administration or injection and alleviating pains and inconvenience of the patients.

Description

technical field [0001] The invention relates to a drug-loaded biodegradable shape memory polymer composite material and a preparation method thereof. Background technique [0002] Shape memory materials are materials that can sense and respond to environmental changes (such as temperature, force, electromagnetic, solvent, etc.) and adjust their state parameters (such as shape, position, strain, etc.) to return to their preset state. Material. Shape memory materials are mainly divided into shape memory alloys, shape memory ceramics, shape memory polymers and shape memory composites according to their different materials. Shape memory alloys were developed earlier. As early as the 1950s, a research team at the University of Illinois in the United States discovered that Au47.5Cd (% atoms) had the phenomenon of self-recovery of the original shape before deformation after plastic deformation. In the following decades, Over time, material scientists have synthesized a variety of...

Claims

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Application Information

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IPC IPC(8): A61K47/34
Inventor 周绍兵肖宇蒋婧
Owner SOUTHWEST JIAOTONG UNIV
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