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Agent for protecting pig mycoplasma vaccine and promoting absorption as well as production method and use method thereof

A technology of mycoplasma suis and absorbent, which is applied in the direction of medical formulas, bacterial antigen components, and medical preparations of non-active ingredients, etc., can solve the problems of difficult vaccination and inconvenient use of mycoplasma pneumonia vaccination, and achieve improved drug absorption rate, The effect of reducing the clearance rate and prolonging the residence time

Inactive Publication Date: 2009-03-04
SHANXI HAISEN BIOLOGIC PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a protective absorbent for Mycoplasma suis vaccine, which assists Mycoplasma suis pneumonia vaccine to achieve nasal spray administration, so as to solve the problems of difficulty in vaccination and inconvenient use of Mycoplasma suis pneumonia vaccine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 4g of Carbomer 934, 3g of Tween-80, and 1g of serum, mix together, add 92g of normal saline and mix evenly, filter and sterilize, then pack in sterilized 100mL bottles, and pass the sterility test, content test and safety After the inspection, the Mycoplasma suis vaccine protection absorber is prepared and stored at 2-8°C.

Embodiment 2

[0028] According to the volume ratio of 1:30, put the inactivated vaccine of Mycoplasma suis pneumonia and the protective absorbent of Mycoplasma suis vaccine of Example 1 into a hand-pressed spray bottle, and shake them well. Spray about 2 mL into the nasal cavity of each pig, 1 mL in each nostril, and avoid drinking water and contacting water sources within 1 hour of spray inoculation.

Embodiment 3

[0030] 11 litters of 106 suckling piglets were selected from a pig farm without mycoplasma pneumonia, and they were randomly divided into 4 groups. 26 heads of the first group, 1 part of thoracic injection of mycoplasma pneumonia attenuated live vaccine at the age of 15 days; 26 heads of the 2nd group, at the age of 15 days, the nasal spray was added with the inactivation of mycoplasma pneumoniae of the present invention's vaccine protection absorbent 1 head of the vaccine; 27 heads of the third group, at the age of 15 days and 30 days of age, each 1 head of the inactivated Mycoplasma pneumoniae vaccine was injected intramuscularly; 27 heads of the fourth group were not injected with the Mycoplasma pneumoniae vaccine as a control.

[0031] After vaccination, cohabitation infection and challenge tests were carried out at 120 days, 180 days and 240 days, respectively. Clinical X-ray chest X-ray examination shows that at 240 days, the immune protection rate of the first group is ...

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PUM

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Abstract

A protective absorbent for a vaccine against swine mycoplasma pneumonia is prepared from carbomer as a base material, Tween-80 as an absorption promoting agent, a small amount of blood serum, and normal saline as a diluent. The application method of the protective absorbent comprises the steps of mixing the protective absorbent with an inactivated vaccine against swine mycoplasma pneumonia according to a volume ratio of 1:30, loading into a spray bottle, sufficiently shaking, and spraying into the nasal cavity of swine. The vaccine inoculation method prolongs the retention time of medicinal ingredients in the nasal cavity of swine, improves absorption rate and capacity of medicinal ingredients, and reduces nasal cilia clearance ratio. Compared with conventional intrapleural injection and intramuscular injection, the vaccine inoculation simplifies the application method of the vaccine against swine mycoplasma pneumonia and improves the epidemic prevention efficiency, with no significant difference with respect to protection ratio.

Description

technical field [0001] The invention belongs to the technical field of biological products, and relates to an animal vaccine protective absorbent, in particular to a swine mycoplasma vaccine protective absorbent, and also relates to a production and use method of the protective absorbent. Background technique [0002] Mycoplasma pneumonia of swine (MPS), also known as swine asthma or swine panting disease, is a contagious respiratory infectious disease of pigs caused by Mycoplasma hyopneumoniae (M.hyo), Mare, Switzer in 1965 and Goodwin confirmed that the pathogen of this disease is Mycoplasma pneumoniae, and suggested that the disease be named "porcine enzootic pneumonia or mycoplasma pneumonia". The disease is characterized by coughing and wheezing as the main clinical manifestations, while there is no significant change in body temperature and appetite. Pigs with secondary infection may show symptoms such as loss of appetite, dyspnea or wheezing, worsening cough, elevate...

Claims

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Application Information

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IPC IPC(8): A61K39/02A61K47/34A61K47/32A61P31/04A61K47/26
Inventor 乔云龙孙建刚
Owner SHANXI HAISEN BIOLOGIC PRODS
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