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Arginine ibuprofen tablet and preparation method thereof

An arginine ibuprofen and tablet technology, which is used in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of large production and storage space, large proportion of excipients, poor patient tolerance, etc. problem, to achieve the effect of low cost, fast onset and easy portability

Active Publication Date: 2009-03-25
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But although syrup and granule can achieve quick effect, the problem of existence is that the taste is pungent, and the patient's tolerance is poor.
Moreover, the production and storage takes up a lot of space, the proportion of auxiliary materials is large, and the cost is high

Method used

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  • Arginine ibuprofen tablet and preparation method thereof
  • Arginine ibuprofen tablet and preparation method thereof
  • Arginine ibuprofen tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Every 1000 arginine ibuprofen tablet preparations, weigh materials according to the following formula:

[0037] Arginine Ibuprofen 370g

[0038] Starch 55.5g

[0039] 8% starch slurry appropriate amount

[0040] Magnesium Stearate 1.5g

[0041] The arginine ibuprofen tablet of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:

[0042] 1. Sieve ibuprofen arginine and starch through a 100-mesh sieve and mix well;

[0043] 2. Take 8% starch slurry, add it to the mixture in step 1, and stir while adding to make a soft material;

[0044] 3. Pass the soft material through a 20-mesh sieve to make wet granules;

[0045] 4. Dry the wet granules at 50-60°C;

[0046] 5. Use a 20-mesh sieve to sieve the dry granules in step 4, add magnesium stearate, mix well, and press into tablets.

Embodiment 2

[0048] Every 1000 arginine ibuprofen tablet preparations, weigh materials according to the following formula:

[0049] Arginine Ibuprofen 370g

[0050] Microcrystalline Cellulose 80g

[0051] 5% hypromellose aqueous solution 60ml

[0052] Magnesium stearate 1.8g

[0053] The arginine ibuprofen tablet of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:

[0054]1. Sieve ibuprofen arginine and microcrystalline cellulose through a 100-mesh sieve and mix well;

[0055] 2. Take 5% hypromellose aqueous solution, add it to the mixture in step 1, stir while adding, and make a soft material;

[0056] 3. Pass the soft material through a 20-mesh sieve to make wet granules;

[0057] 4. Dry the wet granules at 50-60°C;

[0058] 5. Use a 20-mesh sieve to sieve the dry granules in step 4, add magnesium stearate, mix well, and press into tablets.

Embodiment 3

[0060] Every 1000 arginine ibuprofen tablet preparations, weigh materials according to the following formula:

[0061] Arginine Ibuprofen 185g

[0062] Microcrystalline Cellulose 100g

[0063] Lactose 125g

[0064] Magnesium stearate 4.1g

[0065] The arginine ibuprofen tablet of the present invention is prepared by the raw and auxiliary materials taken according to the following steps:

[0066] 1. Arginine ibuprofen, microcrystalline cellulose, and lactose were passed through a 60-mesh sieve, and mixed;

[0067] 2. Take magnesium stearate, add it to the mixture in step 1, mix well, and press into tablets.

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Abstract

The invention relates to an arginine ibuprofen tablet which is antipyretic and analgesic, and a preparation method. The arginine ibuprofen tablet contains arginine ibuprofen and auxiliary material by weight proportion: 30%-90% of arginine ibuprofen, 10%-70% of auxiliary material and 0-10% of coating material. The preparation method adopts raw material direction compression or granule preparation; the prepared tablet can be coated or not be coated. The arginine ibuprofen tablet has short response time. As indicated in dissolution test, the dissolution rate is more than 95% in 20 minutes. 20 male volunteers take two preparations of arginine ibuprofen tablets (equal to 400 mg of ibuprofen) and ibuprofen tablets (400mg) for relative bioavailability research; the peak time of arginine ibuprofen tablet is 0.5h and the peak time of ibuprofen tablet is 2.0h. The test indicates that the arginine ibuprofen tablet has quick absorption and short peak time. Besides, the arginine ibuprofen tablet overcomes the pungent taste of arginine ibuprofen syrup and granules and can be taken by patients conveniently, so as to have the advantages of convenient carrying and low cost.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to antipyretic and analgesic arginine ibuprofen tablets and a preparation method thereof. Background technique [0002] Ibuprofen is a commonly used non-steroidal anti-inflammatory and analgesic drug in clinic, and its analgesic effect is remarkable. Ibuprofen is almost insoluble in water, the pharmacokinetic parameter T of its tablet max The value (time to reach maximum blood concentration) is 1.5-2 hours, and the onset of action is relatively slow. Arginine ibuprofen salt is a water-soluble derivative of ibuprofen, and the reported dosage form is syrup 1 and granules 2 , are water-soluble quick-acting preparations, increasing the absorption rate in vivo. But although syrup and granule can achieve quick effect, the problem of existence is that taste is pungent, and patient tolerance is poor. And the production and storage takes up a lot of space, the proporti...

Claims

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Application Information

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IPC IPC(8): A61K9/30A61K31/192A61P29/00
Inventor 王润玲杨金荣张庆伟
Owner TIANJIN MEDICAL UNIV
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