Arginine ibuprofen tablet and preparation method thereof

Abstract

The invention relates to an arginine ibuprofen tablet which is antipyretic and analgesic, and a preparation method. The arginine ibuprofen tablet contains arginine ibuprofen and auxiliary material by weight proportion: 30%-90% of arginine ibuprofen, 10%-70% of auxiliary material and 0-10% of coating material. The preparation method adopts raw material direction compression or granule preparation; the prepared tablet can be coated or not be coated. The arginine ibuprofen tablet has short response time. As indicated in dissolution test, the dissolution rate is more than 95% in 20 minutes. 20 male volunteers take two preparations of arginine ibuprofen tablets (equal to 400 mg of ibuprofen) and ibuprofen tablets (400mg) for relative bioavailability research; the peak time of arginine ibuprofen tablet is 0.5h and the peak time of ibuprofen tablet is 2.0h. The test indicates that the arginine ibuprofen tablet has quick absorption and short peak time. Besides, the arginine ibuprofen tablet overcomes the pungent taste of arginine ibuprofen syrup and granules and can be taken by patients conveniently, so as to have the advantages of convenient carrying and low cost.

Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to antipyretic and analgesic arginine ibuprofen tablets and a preparation method thereof. Background technique

[0002] Ibuprofen is a commonly used non-steroidal anti-inflammatory and analgesic drug in clinic, and its analgesic effect is remarkable. Ibuprofen is almost insoluble in water, the pharmacokinetic parameter T of its tablet max The value (time to reach maximum blood concentration) is 1.5-2 hours, and the onset of action is relatively slow. Arginine ibuprofen salt is a water-soluble derivative of ibuprofen, and the reported dosage form is syrup 1 and granules 2 , are water-soluble quick-acting preparations, increasing the absorption rate in vivo. But although syrup and granule can achieve quick effect, the problem of existence is that taste is pungent, and patient tolerance is poor. And the production and storage takes up a lot of space, the proporti...

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