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Dried wood-louse extract, preparation method and use thereof in preparing analgesic

The technology of extract and shamrock, applied in the field of saffron extract and preparation, can solve the problems of poor patient acceptance, obvious side effects, difficult to eliminate pain, etc., to avoid large toxic and side effects, high bioavailability and efficacy long time effect

Inactive Publication Date: 2009-03-25
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few researches on the preparations of rat women, and most of them are pills and tablets of traditional prescriptions, and there are problems such as thick, large, black, slow effect and inconvenient use of traditional Chinese medicines, and the patients' acceptance is poor
[0004] Most of the currently used analgesics are opioid alkaloids, which have strong analgesic effects, but continuous use can cause addiction and are not suitable for long-term use. They also have inhibitory effects on the respiratory center, and toxic doses can lead to respiratory depression and death
Synthetic non-morphine analgesics, non-steroidal analgesics, etc. have strong analgesic effects, but they all have obvious side effects, and their use is restricted
Most antipyretic and analgesic products damage the hematopoietic system or cause allergic reactions, etc., and the analgesic effect is weak, especially for the pain in the late stage of cancer. Pain has not been well documented

Method used

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  • Dried wood-louse extract, preparation method and use thereof in preparing analgesic
  • Dried wood-louse extract, preparation method and use thereof in preparing analgesic
  • Dried wood-louse extract, preparation method and use thereof in preparing analgesic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Take the dried body of sarcophagus, crush it, soak it in water at a ratio of 1:8 (w / v) for 30 minutes, decoct it for 3 hours, centrifuge to discard the precipitate, concentrate the supernatant to 3g crude drug / ml extract, add it under stirring 95% ethanol to 50% alcohol content, precipitate, centrifuge to discard the precipitate, take the supernatant and concentrate under reduced pressure to a thick extract with a relative density of 1.19-1.24 (20°C) or dry it into extract powder to obtain the extract.

Embodiment 2

[0053] Take the dried body of sarcophagus, crush it, soak it in water at a ratio of 1:10 (w / v) for 60 minutes, decoct it for 3 hours, discard the precipitate by centrifugation, concentrate the supernatant to 3g crude drug / ml extract, and add it under stirring 95% ethanol to 50% alcohol content, precipitate, centrifuge to discard the precipitate, take the supernatant and concentrate under reduced pressure to a thick extract with a relative density of 1.19-1.24 (20°C) or dry it into extract powder to obtain the extract.

Embodiment 3

[0055] Preparation of Compound Shufu Dropping Pills

[0056] prescription:

[0057]

[0058] Preparation method: Weigh 4.0g of sarcophagus extract, 1.0g of borneol, 4.25g of water-soluble matrix polyethylene glycol 6000, and 0.75g of poloxamer 188 according to the prescription, heat and melt in a water bath at 70-75°C, and mix well , transferred to the liquid storage bottle of the dropping pill machine, kept warm at 70-75°C, the nozzle temperature was 27-30°C, adjusted the dropping speed at 20d / min, dropped into the coolant with a temperature of 5-10°C, and dripped into pills Finally, drain the coolant and dry at room temperature to obtain the compound Shufu dropping pills. The time limit for dissolving and dispersing is 14.53 minutes, and the difference in weight of the pills is within ±15%.

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Abstract

The invention relates to a pillbug extract, a preparation method and the application in the preparation of analgesic medicines; baked-dried pillbug powder is crushed and added into water to be decocted; then supernatant is obtained after centrifugation; the supernatant solution is decompressed and condensed, and added with ethanol for sedimentation, then the supernatant is obtained after centrifugation, so as to obtain pillbug extract extractum after decompressed condensation; the pillbug extract extractum can be made into dropping pills, dispersible tablets and sustained-release tablets, can be used for the treatment of stomatitis, tonsillitis, acute and chronic pain and other symptoms. The dropping pills and dispersible tablets have the advantages of short disintegrating time, good absorption and high bioavailability; the sustained-release tablets release stably, have long efficacy and are used for the treatment of chronic pain so that patients have better compliance. Because pillbug is non-toxic, non-addictive and has good analgesic effect, the pillbug extract is good analgesic agent and has good market prospect.

Description

technical field [0001] The invention provides an extract of succulents and a preparation method thereof, which are used in the preparation of analgesics, and belong to the technical field of extraction methods of traditional Chinese medicines and preparations of traditional Chinese medicines. technical background [0002] The murine is the dried whole body of the murine gynecologist, the flat beetle (Armadillidiam vulgare). Porcellio, also known as mouse negative, negative pan, mouse aunt, mouse sticky, ground louse, etc., is a member of the genus Porcellio of the suborder Oniscoidea of ​​the order Oniscidae of the crustacea (CRUSTACEA) and the order Isopoda (ISPODA). ) is a common name for animals. There are more than 150 species in the world, most of which are widely distributed worldwide. The common species in China are rat woman, smooth rat woman and so on. Rats are sour in taste and cool in nature. The function is to dispel blood and relieve pain, diuresis, and detox...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/22A61P29/00A61P25/04
Inventor 滕利荣孟庆繁刘丹梅周杰田晓乐苏正兴孙凤英
Owner JILIN UNIV
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