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Traditional Chinese medicine composition for treating cough and asthma and preparation and quality control method thereof

A quality control method and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problems of chemical drugs that cannot be cured, large dosages, and unstable curative effects.

Active Publication Date: 2009-04-01
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among the medicines for treating cough and asthma, chemical medicines are only symptomatic and cannot cure the disease, while most traditional Chinese medicines have a long course of treatment, large dosage, and unstable curative effect

Method used

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  • Traditional Chinese medicine composition for treating cough and asthma and preparation and quality control method thereof
  • Traditional Chinese medicine composition for treating cough and asthma and preparation and quality control method thereof
  • Traditional Chinese medicine composition for treating cough and asthma and preparation and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0077] Experimental example 1. The preferred experiment of the preparation process of the traditional Chinese medicine composition of the present invention

[0078] 1. Research on extraction process

[0079] 1.1 Research on the amount of water added for water extraction: In the original extraction process, the volume of the solvent added was not specified, but in the actual production process, the volume of the extraction solvent added is an important parameter, which has a great impact on the quality of the extracted extract, so it is researched During the process, the original extraction process was perfected to ensure the scientificity and controllability of the extraction process.

[0080] According to the prescription ratio of Example 3, configure 3 medicinal materials, each 187.5g, divided into four groups to test, the first group added 6 times the amount of water, 4 times the amount, the second group added 8 times the amount of water, 6 times the amount, the third Add 10 ti...

experiment example 2

[0137] Experimental Example 2. Screening of the method for identifying the taste of each medicine in the Chinese medicine group and its contents of the present invention

[0138] Shoot dry

[0139] Method 1: Take the content of this pharmaceutical composition preparation equivalent to 40g crude drug, grind it into fines, add 50ml methanol, sonicate for 30 minutes, filter, evaporate the filtrate, add 40ml water to the residue to dissolve, add n-butanol to shake and extract three times , 20ml each time, combine the n-butanol solution, evaporate to dryness, add 2ml methanol to the residue to dissolve it as the test solution. According to the preparation method of the test product and the sample solution, prepare the negative sample solution of deficiencies; take another 1g of radican reference medicinal materials, add 15ml of methanol, sonicate for 30 minutes, filter, and concentrate the filtrate to 1ml as the reference medicinal solution. According to thin-layer chromatography (Chin...

experiment example 3

[0168] Experimental example 3. Screening of content determination method

[0169] The HPLC method is used to determine the content of icariin in the medicine of the present invention to improve the quality detection method of the present invention. Some test results are as follows:

[0170] ① Preparation of test solution

[0171] Take 20 tablets of this product, remove the film coating, grind finely, take about 1g, accurately weigh it, place a stoppered conical flask, accurately add 20ml of dilute ethanol, weigh it, and ultrasonically treat (power 250W, frequency 50kHz) , Let it cool, weigh it again, make up the lost weight with dilute ethanol, shake well, filter, and take the filtrate to get it. The content of icariin in the test solution was compared for different ultrasound time. The results are as follows:

[0172] Table 10 Selection of ultrasound time

[0173] Ultrasound time 20 minutes 40 minutes 60 minutes 80 minutes Icariin content (mg / g) 0.4307 0.6...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating cough and asthma diseases, a preparation method and a quality control method thereof. The composition is made from the bulk drugs blackberrylily rhizome, platycodon root, epimedium, hawthorn fruit (crude), peppergrass, houttuynia, astragalus root, Chinese ephedra (roasted), earthworm, Chinese yam rhizome, common anemarrhena rhizome, gecko and the like, high performance liquid chromatography is adopted in the quality control method to assay the epimedium, and thin layer chromatography is employed to quanlitatively identify the blackberrylily rhizome, the platycodon root, the epimedium, the astragalus root, the Chinese ephedra (roasted) and the earthworm. The composition has outstanding curative effect and the functions of nourishing qi and kidney, removing heat from the lung and dissolving phlegm, and relieving cough and asthma. The composition has very good curative effect on the cough and asthma caused by the qi deficiency of lung and kidney as well as the phlegm-heat stagnating in lung, acute bronchitis, chronic bronchitis and bronchial asthma with the syndromes.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cough and asthma, and a preparation method and quality control method thereof, in particular to a traditional Chinese medicine for treating cough and asthma caused by lung and kidney qi deficiency, phlegm-heat stagnation in the lung, acute and chronic bronchitis, and bronchial asthma The composition and the preparation method and the quality control method thereof belong to the technical field of traditional Chinese medicine. Background technique [0002] Cough and asthma include asthma, bronchitis and other diseases. It is a group of common and difficult diseases worldwide. According to the World Health Organization: "Asthma causes more harm to human health and economic burden than tuberculosis and AIDS combined." As the degree of environmental pollution continues to increase, the incidence and mortality of asthma are increasing year by year. At present, there are 150 to 200 m...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/16A61K9/20A61K9/48A61P11/06A61P11/14G01N30/02G01N30/90A61K35/64A61K35/583A61K35/62
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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