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Levorotation carnitine acid calcium phosphate, preparation method and use thereof

A technology of L-carnitine calcium dihydrogen phosphate and its use, applied in the preparation of pharmaceutical intermediates and food additives, nutritional supplement compositions for calcium and phosphorus supplementation, L-carnitine calcium dihydrogen phosphate and its preparation fields, can solve the problem of There are no problems such as mass production and expensive prices, and it is suitable for oral administration, increasing the effect of calcium and phosphorus supplementation, strong and more functional nutrition and therapeutic effects

Active Publication Date: 2009-04-08
リャオニンコンセプヌトラシーオーエルティーディー
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the double salt formed with calcium ions, so far, only L-carnitine calcium galactarate and L-carnitine calcium fumarate (WO2008080287) have patent reports, but there is no large-scale production in China, and the price is relatively expensive

Method used

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  • Levorotation carnitine acid calcium phosphate, preparation method and use thereof
  • Levorotation carnitine acid calcium phosphate, preparation method and use thereof
  • Levorotation carnitine acid calcium phosphate, preparation method and use thereof

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Embodiment 1

[0027] Preparation of L-Carnitine Dicalcium Phosphate

[0028]

[0029] Dissolve calcium hydroxide in water, add phosphoric acid, stir and react for 2-8 hours, add L-carnitine after filtration, stir at room temperature for 8-10 hours, concentrate, and crystallize in ethanol to obtain L-carnitine dicalcium phosphate. Yield 98.6%.

[0030] The obtained L-carnitine calcium dihydrogen phosphate has good fluidity, and the powder is uniform, and more than 98% of the powder is less than 40 mesh. Good water solubility under acidic conditions. Expose for 24 hours at a relative humidity of 60±5% at 25°C, no agglomeration and stickiness, good moisture absorption resistance, and a calcium content of 9.28%. Moisture <1%.

[0031] [α] D 20 =-10.08 (1%H 2 O)

[0032] HPLC:

[0033] Column: APS-2HYPERSIL (NH 2 )(5μm)250×4.6mm

[0034] Temperature: 30°C

[0035] Mobile phase: KH 2 PO 4 / Acetonitrile(70 / 30)(v / v)

[0036] pH: 4.0H 3 PO 4

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Abstract

The invention relates to L-carnitine calcium biphosphate and a preparation method and application thereof. The L-carnitine calcium biphosphate has the characteristics of suitability for oral administration, stability and non-moisture absorption property, has stronger nutrition and therapeutic action compared with corresponding internal salt, and has good water solubility under weak acid conditions. The preparation method comprises the following steps: dissolving calcium hydroxide in water, adding phosphoric acid, stirring the mixture to react, adding L-carnitine after filtering, stirring the mixture to room temperature, concentrating the mixture, and performing crystallizing in alcohol to obtain the L-carnitine calcium biphosphate which is detected as a qualified product. A composition containing the L-carnitine calcium biphosphate can be made into one or more pharmacologically acceptable excipients, in particular solid and liquid oral preparations, such as powder, grains, tablets, capsules, oral liquids, and the like, and can be used for diet / nutrition enriching substances for the human or fodder enriching substances for animals, including the enriching substances for supplementing calcium and phosphor.

Description

technical field [0001] The invention relates to a stable and non-hygroscopic pharmaceutically acceptable salt of L-carnitine, in particular to a kind of L-carnitine dicalcium phosphate and its preparation method and application, belonging to the preparation technology of pharmaceutical intermediates and food additives , suitable for preparing nutritional supplements for humans or animals, including a nutritional supplement composition for calcium and phosphorus supplementation. Background technique [0002] There have been many reports on the efficacy of L-carnitine. L-carnitine is an important food nutrition fortifier, which has been widely used in the food industry, such as infant milk powder, diet food, nutrition products for athletes and nutritional supplements for middle-aged and elderly people, as well as feed additives. In the industry, there are also medical effects. Cardiovascular disease, liver disease, kidney disease, hyperlipidemia, diabetes, neuromuscular diseas...

Claims

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Application Information

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IPC IPC(8): C07C229/22C07C227/18A61K31/205A61P3/02
Inventor 卿笃清袁学亮张薇薇梅国庆
Owner リャオニンコンセプヌトラシーオーエルティーディー
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