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Method for dielectric characterization of micro-nano biological particle by optoelectronic forceps

A biological particle, micro-nano technology, applied in the direction of material analysis, biological testing, and material inspection products by electromagnetic means, can solve the problems of high production cost and complex micro-electrode structure.

Inactive Publication Date: 2009-04-08
SOUTHEAST UNIV
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Problems solved by technology

[0006] Technical problem: The purpose of the present invention is to provide a method for dielectrically characterizing micro-nano biological particles using photoelectric tweezers, so as to solve the defects of high manufacturing cost and complex microelectrode structure of general biological particle dielectric characterizing chips. Greatly expand the application field of photoelectric tweezers

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  • Method for dielectric characterization of micro-nano biological particle by optoelectronic forceps
  • Method for dielectric characterization of micro-nano biological particle by optoelectronic forceps

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Embodiment Construction

[0024] For an embodiment of the method for using photoelectric tweezers to carry out dielectric characterization of biological particles provided by the present invention, see figure 1 and figure 2 . The chip structure, material and pattern of the light patterns that can be used in this method are not limited to this embodiment.

[0025] The dielectric characterization chip used in this embodiment includes a first sample inlet 1101, a second sample inlet 1102, a third sample inlet 1103, a transparent insulating cover sheet 120, an upper transparent indium tin oxide film 130, and a second sample inlet 1103. A microfluidic chamber 1401, a second microfluidic chamber 1402, a third microfluidic chamber 1403, an intermediate spacer layer 150, a transparent insulating substrate 160, and a virtual silicon nitride layer 171, a photoconductive layer 172 and a transparent conductive layer 173. The electrode forms the layer 170 . The silicon nitride layer 171 can prevent hydrolysis, an...

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Abstract

The invention provides a method used for carrying out dielectric characterization to micro-nanometer biological particles by utilizing photoelectric forceps, comprising the steps as follows: the movement speed of an optical pattern is gradually changed so as to lead the particle to reach the maximum synchronous speed before out-of-step; and by being combined with the frequency adjustment of an excitation signal, the maximum synchronous speed curve of the biological particle in a certain frequency range of the excitation signal is measured, thus completing the dielectric characterization of the particle. The dielectric characterization method provided by the invention sufficiently utilizes the flexibility advantage of the photoelectric forceps and avoids preparing a complex physical entity electrode array on the chip simultaneously, is better than the existing dielectric characterization method of the micro-nanometer particle on the aspects of cost, function and performance, and provides an extremely important means for the leaping development of the biomedical detection field.

Description

technical field [0001] The invention relates to a method for characterizing and identifying micro-nano biological particles by using a photoelectric microfluidic device, and relates to the field of microfluidics, in particular to the field of microfluidic biomedical chips. Background technique [0002] The dielectric properties of micro-nano biological particles are closely related to their structure and chemical composition, which can be used as a "fingerprint" to identify specific types of micro-nano biological particles. The process of obtaining the dielectric properties of particles is called dielectric characterization. Electrorotation dielectrophoresis (ROT-DEP) is one of the technologies used for the dielectric characterization of biological particles. It uses several alternating voltage signals of different phases to form a rotating electric field on the electrorotation chip, and the tiny particles can Rotation occurs under the action of a rotating electric field. ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N27/00
Inventor 易红朱晓璐倪中华
Owner SOUTHEAST UNIV
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