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Imitated erythrocyte membrane with high blood compatibility

A blood compatibility and cell membrane technology, applied in the field of imitation red blood cell membrane, can solve the problems of poor biocompatibility between materials and artificial organs and blood, and achieve excellent surface anticoagulation, good adhesion ability, easy and uniform film formation Effect

Inactive Publication Date: 2009-04-22
苏州领航生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides a highly blood-compatibility imitation red blood cell membrane, aiming to solve the problem of poor biocompatibility between existing implantable devices, materials and artificial organs and blood

Method used

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  • Imitated erythrocyte membrane with high blood compatibility
  • Imitated erythrocyte membrane with high blood compatibility
  • Imitated erythrocyte membrane with high blood compatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: A highly blood-compatible imitation red blood cell membrane is prepared from the following raw materials and methods:

[0036] Step 1: Fully dissolve 5 grams of medical polyvinyl chloride in 100 ml of tetrahydrofuran to obtain a tetrahydrofuran solution containing medical polyvinyl chloride.

[0037] The second step: the tetrahydrofuran solution containing medical polyvinyl chloride obtained in the first step is evenly coated on the surface of the implantable device, and then in a clean environment (dust-free and sterile) at 25 ° C and a relative humidity of 50% to 60%. ) to form a medical polyvinyl chloride substrate on the surface of an implantable device or an artificial organ through the natural evaporation of tetrahydrofuran;

[0038] Step 3: Submerge the implantable device or artificial organ formed with a medical polyvinyl chloride substrate in a methanol solution containing a phosphorylcholine polymer for 3 to 7 seconds; then put it in a glass vacu...

Embodiment 2

[0044] Embodiment 2: A highly blood-compatible imitation red blood cell membrane is prepared from the following raw materials and methods:

[0045] Step 1: Fully dissolve 4 grams of medical polyvinyl chloride in 100 ml of tetrahydrofuran to obtain a tetrahydrofuran solution containing medical polyvinyl chloride.

[0046] The second step: the tetrahydrofuran solution containing medical polyvinyl chloride obtained in the first step is evenly coated on the surface of the implantable device, and then placed in a clean environment (dust-free and sterile) at 24 ° C and a relative humidity of 50% to 60%. ) to form a medical polyvinyl chloride substrate on the surface of an implantable device or an artificial organ through the natural evaporation of tetrahydrofuran;

[0047] The third step: immerse the implantable device or artificial organ formed with a medical polyvinyl chloride substrate in a methanol solution containing a phosphorylcholine polymer for 3 to 7 seconds. The mass vol...

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Abstract

The invention relates to a simulated erythrocyte membrane with high degree of blood compatibility. Medical polyvinyl chloride and phosphoryl choline high molecular polymer are used as raw materials; and the phosphoryl choline high molecular polymer is fixed on the surface of the medical polyvinyl chloride substrate to form the simulated erythrocyte membrane with high degree of blood compatibility. After the obtained simulated erythrocyte membrane contacts with human blood for 30 minutes, the surface of the membrane keeps smooth and clean and has no hemagglutination phenomenon, so the simulated erythrocyte membrane shows favorable surface anticoagulation.

Description

technical field [0001] The invention relates to a highly hemocompatibility imitation red blood cell membrane, which is mainly used for adhering to various artificial organs (artificial blood vessels, artificial bones, eyeball lenses and implantable teeth, etc.), various implantable therapeutic Appliances (cardiac pacemakers, coronary stents, insulin capsules, cosmetic filling materials, etc.), ICU (Intensive Care Unit, Intensive Care Unit) clinical real-time monitoring devices (implantable sensors, medical catheters) and direct communication with organisms Surfaces of supplies and materials that come into contact with the wound, making them biocompatible with blood. Background technique [0002] With the development of modern medicine, more and more implantable devices and artificial organs have entered clinical application from laboratory research. These implantable devices and artificial organs are directly implanted in the human body, so in addition to working reliably t...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L29/08A61L31/10
Inventor 张思福
Owner 苏州领航生物科技有限公司
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