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Solid preparation comprising adenosine 5'-triphosphate or physiologically acceptable salt thereof

A technology of adenosine triphosphate and solid preparation, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and pill delivery, etc., can solve the problems such as the decrease of the content of active ingredients over time, the increase of manufacturing costs, and easy decomposition. , to achieve excellent storage stability and the effect of inhibiting swelling

Inactive Publication Date: 2009-06-03
KOWA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, 5'-adenosine triphosphate is unstable to water and easily decomposes. Due to the long-term preservation of the active ingredient content in the preparation, it decreases over time. This additional storage method increases the manufacturing cost associated with desiccant filling, or the problem of poor operability due to refrigeration during distribution
In addition, there are also concerns that consumers may accidentally eat silica gel used as a desiccant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] Mix 600g of 5′-adenosine triphosphate disodium, 240g of dithiothiamine, 240g of pyridoxine hydrochloride, 0.6g of cyanocobalamin, 240g of hydroxypropyl cellulose, 4034.4g of crystalline cellulose, and 600g of carboxymethyl ether cellulose, and add to it 1100 g of ethanol was added, granulated, dried and sized, and 45 g of magnesium stearate was added thereto to prepare granules for tableting. The granules for tableting were compression-molded to obtain one plain tablet of 200 mg (φ8 mm).

[0032] Dissolve and disperse this plain tablet in purified water 2400g, methacrylic acid copolymer-LD410g, talc 123g, triethyl citrate 61.6g, titanium oxide 5.4g to make a film coating solution, pass through a breathable type coating machine (Driaco ——タDRC-650DS type Pauretsu Co., Ltd.) The film coating solution is made into a 220mg film-coated tablet, and the water activity is adjusted to 0.28Aw (25° C.) with the above-mentioned breathable coating machine to obtain the present inventio...

example 2

[0034] Film-coated tablets were obtained in the same manner as in Example 1, and the water activity was adjusted to 0.24 using the above-mentioned air-permeable coating machine.

example 3

[0036] Film-coated tablets were obtained in the same manner as in Example 1, and the water activity was adjusted to 0.19 using the above-mentioned air-permeable coating machine.

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PUM

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Abstract

The present invention provides a solid preparation which comprises adenosine 5'-triphosphate or a physiologically acceptable salt thereof, which has a highly maintained active ingredient content even after being stored for a long period, and which has a moisture activity of 0.28 Aw or lower at 25 DEG C. The solid preparation preferably is in the form of a tablet, more preferably in the form of a film-coated tablet.

Description

technical field [0001] The present invention relates to a stable solid preparation containing adenosine 5'-triphosphate or a pharmaceutically acceptable salt thereof. More specifically, it relates to a solid preparation containing adenosine 5'-triphosphate or a pharmaceutically acceptable salt thereof, which can maintain a high active ingredient content even after long-term storage, and has excellent storage stability. Background technique [0002] 5'-adenosine triphosphate is a compound with high-energy phosphate bonds, and a large amount of energy is released when it is hydrolyzed into 5'-adenosine diphosphate and phosphoric acid. In organisms, in addition to being mainly used as an energy supply source for reactions, adenosine 5'-triphosphate also participates in metabolic reactions as a phosphate donor. [0003] With regard to the utilization of 5'-adenosine triphosphate as a medicine, it is known that it is used for the stabilization of the regulatory function of, for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61K47/38A61K9/20A61P1/04A61K9/30A61P3/00A61K47/02A61P9/04A61K47/14A61P25/00A61K47/32A61P27/02
CPCA61K9/28A61K31/7076A61K9/20A61P1/04A61P1/14A61P3/00A61P9/00A61P9/04A61P25/00A61P27/02A61K33/42
Inventor 狩野祐一郎
Owner KOWA CO LTD
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