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Biocompatibility modified starch sponges
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A technology of biocompatibility and modified starch, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of slow human absorption and clinical application limitations, and achieve good biocompatibility, no toxic side effects, and good curative effect Effect
Active Publication Date: 2014-03-12
BEIJING UNIVERSAL LIKANG TECH CO LTD
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Abstract
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Problems solved by technology
However, the main body of this hemostatic dressing is oxidized cellulose, which is slowly absorbed by the human body, so the clinical application is limited.
Method used
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Embodiment 1
[0089] Put 2g of pregelatinized hydroxypropyl distarch phosphate 51# into 30ml of water, stir continuously to make the starch granules fully swell and disperse in the water to form a uniform suspension, add a few drops of glycerin as a forming agent, and then pour it into the container , pre-cooled at -40°C for 22 hours, then placed in a freeze dryer, and freeze-dried at -40°C with a vacuum of less than 20 Pa for 20 hours to obtain the hemostatic sponge A.
[0090] Take 3g of 51# hemostatic sponge A, add 30ml of water, and form a coagulated water mixture viscous glue after absorbing water, and its viscous work index is 76.42g·sec.
[0091] The test method of the viscous work index of the present invention adopts a physical property analyzer (texture analyzer); the test conditions are: under normal temperature, the speed before the test: 0.5mm / sec; the test speed: 10mm / sec.
[0092] The viscous work index means that the probe will be subjected to the cohesive force of the sampl...
Embodiment 2
[0094] Put 1g of pregelatinized hydroxypropyl distarch phosphate 51# into 30ml of water, stir constantly to make the starch granules fully swell and disperse in the water to form a uniform suspension, then pour it into a container and pre-cool at -40°C After 22 hours, put it into a freeze dryer, freeze-dry for 20 hours at -50°C and a vacuum of less than 20 Pa, and obtain the hemostatic sponge B.
[0095] Please refer to the scanning electronmicrograph of the section of the hemostatic sponge A in Fig. 1, and the scanning electronmicrograph of the section of the hemostatic sponge B in Fig. 2 shows that the addition of a plasticizer in the preparation process reduces the pore size of the sponge pores and increases the density and specificity. surface area.
Embodiment 3
[0097] Put 2g of carboxymethyl starch 66# into 30ml of water, stir continuously to make the starch granules fully swell and disperse in water to form a uniform suspension, then pour it into a container, pre-cool at -40°C for 22 hours, and then put it in In a freeze dryer, freeze-dry for 20 hours at -50°C and a vacuum of less than 20 Pa to obtain a hemostatic sponge C.
[0098] Take 1.5g of 66# hemostatic sponge C, add 30ml of water, and form a coagulated water mixture viscous glue after absorbing water, and its viscous work index is 162.68g·sec.
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Abstract
The present invention relates to a biocompatible modified starch hemostatic sponge / foam and its new use as any of the hemostat, anti-adhesion material, promoting tissue healing material, surgical sealant and tissue adhesive glue. The said modified starch includes any or a composite of more than one of the pregelatinized starch, acid modified starch, oxidized starch, esterified starch, etherized starch, cross-linked starch, and grafted starch, composite modified starch. The said hemostatic sponge / foam in this patent is made from modified starch, or a combination of modified starch with other biocompatible hemostat, blood coagulants, plasticizer etc. via vacuum freeze drying process. The advantages of the modified starch hemostatic foam / sponge include 1) multimodality - it can be applied directly to bleeding wound site; 2) having super biocompatibility which can minimize the risks of anaphylaxis, wound infection and wound healing retardation resulting from applying other animal / human components derived hemostats; 3) having super adhesive properties following water absorption which can create the adhesive matrix of clot to adhere and seal the bleeding vessels and wound tissue in particular when profuse bleeding.
Description
technical field [0001] The invention relates to a biocompatible modified starch sponge, which can be directly used on bloody wounds of humans and mammals. The invention also relates to the application of the sponge as hemostatic material, biocompatible anti-adhesion material, tissue healing promotion material, absorbable surgical sealant, wound tissue glue, and the sponge product thereof. Background technique [0002] Surgical operations and trauma will form bloody wounds, during which a large amount of blood will be lost, and it is necessary to use hemostatic means in time. Applying biocompatible absorbable hemostatic materials on bleeding wounds is a common means of hemostasis. There is an urgent need for surgical hemostasis, trauma, and emergency hemostasis. This shows the importance of providing a safe, effective, easy-to-use and low-cost hemostatic material to the market. [0003] The commonly used surgical absorbable hemostatic materials include the following: [00...
Claims
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Application Information
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