Method for preparing beta-TCP//HAP/Ca2P2O7 multiphase porous bioceramic

A bioceramics, ca2p2o7 technology, applied in the direction of ceramic products, applications, medical science, etc., to achieve the effect of good pore connectivity, simple equipment, and short production cycle

Inactive Publication Date: 2009-06-17
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the composite ceramics prepared by calcined bovine cancellous bone are only dual-phase ceramics, and there are no reports on the preparation of multiphase bioceramics by calcined bovine cancellous bone.

Method used

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  • Method for preparing beta-TCP//HAP/Ca2P2O7 multiphase porous bioceramic
  • Method for preparing beta-TCP//HAP/Ca2P2O7 multiphase porous bioceramic
  • Method for preparing beta-TCP//HAP/Ca2P2O7 multiphase porous bioceramic

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Take a healthy adult bovine femur, remove the surface soft tissue, and use a trepan drill with an inner diameter of 8mm to drill the femoral head and the cancellous bone of the distal femur. Boil in the solution for more than 10 hours; wash the boiled bovine cancellous bone with boiling hot water for more than 10 minutes, rinse with flowing normal temperature water for more than 10 minutes, rinse with deionized water for more than 10 minutes, and treat with serial alcohol for more than 10 minutes. Put the bovine spongy bone in a drying oven at 50°C-70°C to dry for more than 3 days, put the dried bovine spongy bone into a calciner for sintering, the heating rate is 5-10°C / min, and keep warm at 600°C-800°C for 3 hours Above, wait for it to cool down to room temperature naturally, take it out of the calciner. The use concentration is 0.04mol L -1 NH 4 h 2 PO 4 The bovine cancellous bone after degreasing and protein removal was treated with the solution, and at room tem...

Embodiment 2

[0030]Take a healthy adult bovine femur, remove the surface soft tissue, and use a trepan drill with an inner diameter of 8mm to drill the femoral head and the cancellous bone of the distal femur. Boil in the solution for more than 10 hours; wash the boiled bovine cancellous bone with boiling hot water for more than 10 minutes, rinse with flowing normal temperature water for more than 10 minutes, rinse with deionized water for more than 10 minutes, and treat with serial alcohol for more than 10 minutes. Put the bovine spongy bone in a drying oven at 50°C-70°C to dry for more than 3 days, put the dried bovine spongy bone into a calciner for sintering, the heating rate is 5-10°C / min, and keep warm at 600°C-800°C for 3 hours Above, wait for it to cool down to room temperature naturally, take it out of the calciner. The use concentration is 1.00mol·L -1 NH 4 h 2 PO 4 The bovine cancellous bone after degreasing and protein removal was treated with the solution, and at room temp...

Embodiment 3

[0032] Take a healthy adult bovine femur, remove the surface soft tissue, and use a trepan drill with an inner diameter of 8mm to drill the femoral head and the cancellous bone of the distal femur. Boil in the solution for more than 10 hours; wash the boiled bovine cancellous bone with boiling hot water for more than 10 minutes, rinse with flowing normal temperature water for more than 10 minutes, rinse with deionized water for more than 10 minutes, and treat with serial alcohol for more than 10 minutes. Put the bovine spongy bone in a drying oven at 50°C-70°C to dry for more than 3 days, put the dried bovine spongy bone into a calciner for sintering, the heating rate is 5-10°C / min, and keep warm at 600°C-800°C for 3 hours Above, wait for it to cool down to room temperature naturally, take it out of the calciner. The use concentration is 0.60mol·L -1 NH 4 h 2 PO 4 The bovine cancellous bone after degreasing and protein removal was treated with the solution, and at room tem...

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Abstract

The invention relates to a bone issue repair material, in particular to a method for preparing beta-TCP/HAP/Ca2P2O7 multiphase porous bioceramic, which belongs to the biomedicine field. The method comprises the following steps: firstly, performing the degreasing and deproteinization treatment on bovine cancellous bone; secondly, using NH4H2PO4 solutions with different concentrations to treat the degreased and deproteinized bovine cancellous bone; and finally drying and sintering the bovine cancellous bone at high temperature to be prepared into the bioceramic. The prepared material can keep a three-dimensional porous structure of natural bone, has better pore connectivity, can induce the growth of new bone, and has the characteristics of good biological degradability, biocompatibility and good mechanical property. The NH4H2PO4 solutions used to treat the bovine cancellous bone is steadier and can not release ammonia gas which is harmful to human bodies at normal temperature, and the experimental preparation process is safer and healthier.

Description

technical field [0001] β-TCP / HAP / Ca prepared by the present invention 2 P 2 o 7 Multiphase porous bioceramics belongs to the field of biomedicine, mainly related to bone tissue repair. Background technique [0002] The main phase composition of calcined bovine cancellous bone is HAP. The obtained HAP has good biocompatibility and osteoconductivity, maintains the porous three-dimensional structure of natural bone, and has good porosity and pore connectivity. However, HAP is very stable in the body and is not easy to degrade. β-TCP has good biodegradability, but its mechanical properties are relatively poor, so Zheng Qixin et al [Patent Publication No.: CN1511595A] studied Na 4 P 2 o 7 10H 2 O solution soaked bovine cancellous bone to prepare HAP / β-TCP composite bioporous ceramics. The prepared composite material has both micropores and macropores. The micropores can promote the degradation of the material in the body, and the macropores can induce bone growth. enter. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B38/00C04B35/00C04B35/622A61L27/10
Inventor 金海波郭朝邦杨筠毛克亚李江涛
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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