Recombinant porcine pseudorabies virus-porcine propagate and breath complex virus-porcine circovirus genetic engineering strain and application

A porcine pseudorabies virus and respiratory syndrome technology, applied in antiviral agents, virus antigen components, virus/bacteriophage, etc., can solve the problem of unsatisfactory control effect of mutant porcine reproductive and respiratory syndrome virus
CN101457215AInactive Publication Date: 2009-06-17HUAZHONG AGRI UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
HUAZHONG AGRI UNIV
Publication Date
2009-06-17
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the animal virus genetic engineering technique field, especially to a recombinant porcine pseudorabies virus-porcine propagate and breath complex virus-porcine circovirus gene engineering strain construction, a vaccine preparation and applications. The recombinant porcine pseudorabies virus-porcine propagate and breath complex virus-porcine circovirus gene engineering strain E001 lacks the pseudorabies virus main virulence gene TK, glycoprotein genes gG, gE and gI, does not express the functional glycoprotein gG and gE / gI of the pseudorabies virus; and simultaneously expresses a GP5m / M protein antigen of the porcine propagate and breath complex virus classical strain and the porcine propagate and breath complex virus internal variant GP5 protein and porcine circovirus ORF2. The strain can stimulate the porcine to produce protective immunity reaction for resisting pseudorabies virus-porcine propagate and breath complex virus-porcine circovirus, effectively prevent the infection of the pseudorabies virus, the porcine propagate and breath complex virus and porcine circovirus. The invention also discloses a preparation and application of a tervalence genetic engineering vaccine.
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Description

technical field

[0001] The invention belongs to the technical field of animal virus genetic engineering. Specifically relates to the preparation of a recombinant porcine pseudorabies virus-porcine reproductive and respiratory syndrome virus-porcine circovirus genetically engineered strain, the genetically engineered vaccine prepared with the genetically engineered strain and its application. Background technique

[0002] Pseudorabies is an acute infectious disease caused by pseudorabies virus (Pseudorabies virus, referred to as PrV) infecting pigs, cattle, sheep, dogs, cats, rabbits, mice, minks, foxes and other domestic and wild animals. Reservoirs and disseminators of viruses (Mettenleiter et al., Comp Immunol Microbiol Infect Dis. 1991, 14: 151-163). Other animals except pigs are in sporadic form, and usually have symptoms such as fever, itching, and encephalomyelitis after the onset, all of which are fatal infections. The disease is an outbreak in pigs, mainly causing ...

Claims

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