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Nerve conduit stent and preparation method thereof

A nerve conduit and polyhydroxyalkanoate technology, applied in the fields of biomedical materials and tissue engineering, can solve problems such as difficult large-scale production, poor mechanical strength and machining performance, and difficult quality control, and achieve good biocompatibility , broad application prospects, and low production costs

Inactive Publication Date: 2009-07-08
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Collagen and chitosan are natural degradable polymer materials with good biocompatibility, but the disadvantage of this type of material is that the performance is unstable, and the degradation performance is not suitable for mediation due to changes in the host enzyme environment. And mechanical processing performance is poor, it is easy to have problems such as difficulty in controlling its quality in large-scale production, and the disproportion between performance and structural changes, so it is difficult to achieve large-scale production of products
However, due to the bottleneck of Schwann cells, and the high price of nerve factors, it is not suitable for ordinary patients, and both methods have safety problems of implantation in vivo

Method used

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  • Nerve conduit stent and preparation method thereof
  • Nerve conduit stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Preparation of PHBHHx nerve conduit scaffolds with a diameter of 1.5 mm, a length of 12 mm, and a wall thickness of 0.25 mm

[0033] Using polyhydroxybutyrate-hexanoate (PHBHHx, purchased from Shandong Lukang) as raw material, the PHBHHx nerve conduit stent with a diameter of 1.5 mm, a length of 12 mm, and a tube wall thickness of 0.25 mm comprises the following steps:

[0034] 1) In a flask, polyhydroxybutyrate-caproic acid ester and 1,4-dioxane are mixed at a mixing ratio of 10 mL 1,4-dioxane per gram of polyhydroxybutyric acid-caproic acid ester. Stir and heat in a water bath at 60°C, and condense and reflux for about 2 hours to obtain a homogeneous solution;

[0035] 2) Pour the solution obtained in step 1) into two test tubes, add salt particles with a diameter of less than 10 microns and salt particles with a diameter of 50 ± 20 microns, and stir evenly with a glass rod to obtain a uniform mixture. The volume mass ratio of hydroxybutyric acid-caproic acid ester s...

Embodiment 2

[0039] Preparation of PHB nerve conduit scaffolds with a diameter of 2 mm, a length of 30 mm, and a wall thickness of 0.25 mm

[0040] Using poly 3-hydroxybutyrate (PHB, purchased from Shandong Lukang) as a raw material, prepare a PHB nerve conduit stent with a diameter of 2 mm, a length of 50 mm, and a tube wall thickness of 2.5 mm, including the following steps:

[0041] 1) Mix poly 3-hydroxybutyrate and 1,4-dioxane in a flask at a mixing ratio of 20mL 1,4-dioxane per gram of poly 3-hydroxybutyrate, at 70°C Stir and heat in a water bath, and condense and reflux for about 0.5 hours to obtain a homogeneous solution;

[0042]2) Pour the solution obtained in step 1) into two test tubes, add salt particles with a diameter of less than 10 microns and salt particles with a diameter of 60 ± 20 microns, and stir evenly with a glass rod to obtain a uniform mixture. The volume mass ratio of hydroxybutyric acid-caproic acid ester solution and the salt particle below 10 microns in diame...

Embodiment 3

[0045] Preparation of PHBV nerve conduit scaffolds with a diameter of 4 mm, a length of 50 mm, and a wall thickness of 0.25 mm

[0046] Using 3-hydroxybutyrate valeric acid copolyester (PHBV, purchased from Shandong Lukang) as raw material, prepare a PHBV nerve conduit stent with a diameter of 4 mm, a length of 50 mm, and a tube wall thickness of 0.25 mm, including the following steps:

[0047] 1) Mix 3-hydroxybutyrate valeric acid copolyester and 1,4-dioxane in a flask at a mixing ratio of 8 mL 1,4-dioxane per gram of 3-hydroxybutyrate valeric acid copolyester ring, stirred and heated in a water bath at 65°C, and condensed and refluxed for about 4 hours to obtain a homogeneous solution;

[0048] 2) Pour the solution obtained in step 1) into two test tubes, add salt particles with a diameter of less than 10 microns and salt particles with a diameter of 50 ± 20 microns (water-soluble particles are acceptable), and stir evenly with a glass rod. Obtain a homogeneous mixture, whe...

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Abstract

The invention provides a neural catheter stent which comprises poly hydroxyl fatty acid ester. The inner wall of the neural catheter stent is a dense small poriform structure with the aperture of less than 10mum; the external wall is a loose macroporous structure with the aperture of 30-100mum. The neural catheter stent adopts the following steps: the polymers of poly hydroxyl fatty acid ester and organic solvent are mixed into uniform solution, wherein, the mixing proportion is each gram of the polymers of poly hydroxyl fatty acid ester is added with 8-20ml of organic solvent; the solution is added with water-soluble particles with different diameters and stirred uniformly, and then a round bar-shaped die is used for dipping the mixture; when the solution is solidified completely, pore-forming agent is dissolved out to obtain the porous structure. The neural catheter stent adopts the polymers of poly hydroxyl fatty acid ester as materials and has the advantages of excellent biocompatibility, wide raw material source, low production cost, simple preparing method, low requirements to equipment and wide application prospect.

Description

technical field [0001] The invention relates to a nerve guide bracket, in particular to a nerve guide bracket for peripheral nerve defect repair and a preparation method thereof, belonging to the fields of biomedical materials and tissue engineering. Background technique [0002] In modern medicine, there are a large number of patients with peripheral nerve injuries caused by accidents or medical accidents. According to incomplete statistics, there are about 469,000 patients with nerve injuries in the United States every year, and the population of China is about ten times that of the United States. The patient population is also very large. [0003] At present, the main clinical treatment for nerve injury is autologous nerve transplantation. Although this method can effectively repair damaged nerves, it also has great shortcomings. On the one hand, the transplantation of autologous nerves will inevitably damage the nerves in the donor area; on the other hand, some damaged ...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/56A61F2/00
Inventor 吴琼边雨竹陈国强
Owner TSINGHUA UNIV
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