Application of disodium sulfodehydroabietate for treating gastroxia type peptic ulcer and gastrointestinal tract inflammation

Abstract

The invention discloses an application of sulfonating dehydrogenated disodium abietic acid on medicine, and relates to the medicine field of preventing from gastrointestinal tract diseases, in particular to medicine for preventing gastrointestinal tract inflammation and ulceration caused by acid stomach. The patent disclosed in CN00818150.0 shows that sulfogroup dehydrogenated rosin mono-sodium salt is better than disodium salt, but the patent does not further disclose the experimental condition and the data result, thus the pharmacological action and the clinical application condition are worthy to further research. Through comparing acid preparation in vitro effect of the mono-sodium salt with the disodium salt, the dissolution rate and the pharmacodynamic test of the mono-sodium salt with the disodium salt in simulated gastric fluid and simulated intestinal fluid, the invention has the result as follows: the sulfonating dehydrogenated disodium abietic acid has stronger acid making property when curing stomach ulcer, acute gastritis, acute attack of chronic gastritis, faster entogastric and intestinal dissolution speed, higher healing effect and quicker deserted effect.

Description

technical field [0001] The present invention relates to a known drug for the prevention and treatment of peptic inflammation and ulcers, namely the disodium salt of sulfonated dehydroabietic acid and its salts, the disodium salt of sulfonated dehydroabietic acid is used in the treatment of gastric hyperacidity New therapeutic applications for intestinal inflammation and peptic ulcers. Background technique [0002] Peptic ulcer is one of common and frequently-occurring diseases, among which gastric and duodenal ulcers are the most common. The main cause of peptic ulcer is the result of an imbalance between the aggressive factors that damage the gastric and duodenal mucosa and the mucosal self-defense factors. Gastric acid and pepsin are the main components of gastric juice and are the main factors that have an invasion effect on the gastric and duodenal mucosa. That is the so-called "no acid and no ulcer". The average basal gastric acid excretion and acid excretion stimula...

AI Technical Summary

Problems solved by technology

[0010] It can be seen that the protection scope of the above application is very wide. When treating inflammatory intestinal diseases, all salts with sulfonated dehydroabietic acid belong to the protection scope, but in such a broad protection scope, it can be supported by the instructions It is only the monosodium salt of sulfodehydroabietic acid, and other salts of sulfodehydroabietic acid are not supported by the instructions. Their pharmacological effects and clinical application are worthy of further study

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