Application of 3,4-dihydroxy-phenyl-lactic acid in preparing medicament for treating microcirculatory disturbance

A technology of microcirculation disorder and phenyl lactic acid, which is applied in the field of medicine, can solve the problems of clearing peroxide with unclear DLA, unclear DLA, etc.
CN101485648AInactive Publication Date: 2009-07-22TIANJIN TASLY PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN TASLY PHARMA CO LTD
Publication Date
2009-07-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of 3,4-dihydroxyl-phenyl lactic acid in preparing a medicine treating microcirculatory disturbance. Salvia Miltrorrhiza (SM) is contained in a great number of the prior Chinese medicines used to treat blood vessel diseases, and 3,4-dihydroxyl-phenyl lactic acid(DLA) is one of main active ingredients in the Salvia Miltrorrhiza. The microcirculatory disturbance is mesentery microcirculatory disturbance and is caused by ischemia / reperfusion. The invention also discloses application of the 3,4-dihydroxyl-phenyl lactic acid in preparing a medicine for preventing adhesion of white blood cells caused by the microcirculatory disturbance, a medicine for restoring adhesional white blood cells caused by the microcirculatory disturbance, a medicine for inhibiting exudation of albumin from small veins caused by the microcirculatory disturbance, a medicine for inhibiting degranulation of mast cells caused by the microcirculatory disturbance, a medicine for inhibiting expressions of adersional molecules CD11b and CD18 on neutrophilic granulocytes caused by the microcirculatory disturbance and a medicine for inhibiting generation of peroxides caused by the microcirculatory disturbance.
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Description

technical field

[0001] The invention relates to the field of medicine, in particular to the application of 3,4-dihydroxy-phenyl lactic acid in the preparation of medicines for treating microcirculation disturbance caused by ischemia / reperfusion. Background technique

[0002] Ischemia / reperfusion (I / R) causes a large number of microcirculatory damage responses, such as increasing the production of oxygen free radicals from epithelial cells, increasing the expression of L-selectin on leukocytes and E-selectin on endothelial cells, Causes fluctuations in leukocytes, increases the expression of CD11b / CD18 on leukocytes and intercellular adhesion molecule (ICAM-1) on endothelial cells. These molecules enable leukocytes to adhere to postcapillary veins, causing the release of oxygen free radicals that cause damage to the vascular endothelium. In addition, postcapillary venules also respond to I / R with mast cell degranulation and release of vasoactive substances, which have been i...

Claims

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