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Medicament composition for preventing or/and treating decayed tooth and preparation method thereof

A composition and drug technology, which is applied in the direction of drug combination, pharmaceutical formula, fluorine compound active ingredients, etc., can solve the problems of the combined use of Dex and fluoride, and achieve the effect of enhancing the anti-caries effect, reducing toxic and side effects, and reducing dosage

Inactive Publication Date: 2009-08-12
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is currently no combination of Dex with fluoride for the prevention and / or treatment of dental caries

Method used

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  • Medicament composition for preventing or/and treating decayed tooth and preparation method thereof
  • Medicament composition for preventing or/and treating decayed tooth and preparation method thereof
  • Medicament composition for preventing or/and treating decayed tooth and preparation method thereof

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Effect test

Embodiment 1

[0054] Embodiment 1 The preparation of medicine of the present invention

[0055] a. Raw materials are formulated according to the following table:

[0056] b. Dissolve dextranase in 20mM phosphate buffer, pH 6.0, to make a storage solution, which contains dextranase 100U / ml;

[0057] c. Make a mixed solution so that the final concentrations of NaF and dextranase are shown in the table below, add pharmaceutically acceptable adjuvants or adjuvant components, and prepare a paste or a gargle.

[0058] NaF(μg / ml) Dex(U / ml) 80 1 40 1 20 1

[0059] The beneficial effects of the present invention are demonstrated by in vitro experiments below.

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Abstract

The invention provides a medicine combination for preventing and controlling or / and treating decayed teeth, which is prepared by taking dextran enzyme and sodium fluoride as active ingredients; wherein, each milliliter of the medicine combination contains 10-80mug of NaF and 1-4U of dextran enzyme. The invention also provides a preparation method of the medicine combination; the medicine of the invention jointly employs the sodium fluoride with a dosage lower than clinical dosage and Dex to reduce the use amount of the former; the medicine on Sub-MIC thereof can play a role in inhibiting dental plaque biomembrane and effectively increase anticarious effect of fluoride, and decrease toxic side effect thereof, control the biomembrane in light of control of exopolysaccharide and provide experimental basis and clinical choice for improving the healing effect of the medicine while reducing toxicity of the fluoride.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and / or treating dental caries, which belongs to the field of medicines. Background technique [0002] Caries is one of the most common infectious diseases in humans, and the plaque adhering to the tooth surface is the main environment for pathogenic bacteria to survive, metabolize and cause disease. Streptococcus mutans is the dominant bacteria in dental plaque, has strong acid production and acid resistance, is the main cariogenic bacteria, and is also the normal flora in the oral cavity[1,2]. The medicines currently used to prevent and / or treat dental caries mainly include fluoride and chlorhexidine acetate. [0003] Fluoride: The mechanism is to inhibit the demineralization of enamel and dentin and promote their remineralization; inhibit the growth and metabolism of cariogenic bacteria. Fluoride mainly affects the metabolism of microorganisms in dental plaque and acts on the bact...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K33/16A61K9/10A61P1/02
Inventor 胡涛蒋丹仇元新程然宁美芝应瑜
Owner SICHUAN UNIV
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