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Method of preparing 1-phenyl-1-(bicycle [2.2.1]-5-heptylene-2)-ethyl alcohol

A technology of heptene and phenyl, which is applied in the field of preparation of 1-phenyl-1--ethanol, can solve problems such as incomplete organic preparation methods, and achieve the effects of stable reaction, mild reaction and simple reaction conditions

Inactive Publication Date: 2009-08-19
NANCHANG HANGKONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

There are not many studies on this compound abroad, and there is no complete preparation method for synthesizing this organic compound; there is no report on its synthesis in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] 1. Cracking of dicyclopentadiene into monocyclopentadiene

[0011] Equipped with a stirring device, a Kjeldahl distillation head (its branch is connected to a straight condenser tube, the lower port of the condenser tube is connected to a vacuum tail joint, the lower port of the vacuum tail joint is connected to a single-necked bottle, the single-necked bottle is cooled with ice salt water, and the vacuum tail joint Add 200 grams of dicyclopentadiene in the 250 milliliters of four-necked bottles of the thermometer, and heat to 170 ℃ and carry out atmospheric distillation. Fractions at 41.5°C were collected. Quickly weigh the obtained product, and calculate the amount of methyl ketene and anhydrous ether used in the next step. After weighing, insert a drying tube into the receiving bottle containing the product, and continue cooling with ice-salt water. After the next step is set up, it will be used for the next step of reaction immediately.

[0012] 2. Diels-Alder rea...

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PUM

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Abstract

The invention discloses a method for preparing 1-phenyl-1-(dicyclo [2, 2, 1]-5-heptylene-2)-ethanol. The method is characterized by firstly heating dicyclopentadiene to 170 DEG C to crack into monocyclopentadiene which then reacts with methylketene by Diels-Alder at room temperature to obtain bridged cyclic ketone, and lastly adding the bridged cyclic ketone into Grignard reagent synthesized from iodine-induced bromobenzene and magnesium by taking absolute ethyl ether as solvent to carry out Grignard reaction so as to prepare the target product. As organic compounds containing the structure of the 1-phenyl-1-(dicyclo [2, 2, 1]-5-heptylene-2)-ethanol and a series of medicaments synthesized by taking the 1-phenyl-1-(dicyclo [2, 2, 1]-5-heptylene-2)-ethanol as intermediate product have function of treating symptoms of neurology and psychiatry, so the 1-phenyl-1-(dicyclo [2, 2, 1]-5-heptylene-2)-ethanol is a medicinal intermediate product having potential researching value. The method has advantages of simple reaction conditions, mild and stable reaction, and is easily operated in workshops.

Description

technical field [0001] The invention relates to a preparation method of 1-phenyl-1-(bicyclo[2.2.1]-5-heptene-2)-ethanol. Background technique [0002] 1-Phenyl-1-(bicyclo[2.2.1]-5-heptene-2)-ethanol, because of the organic matter containing this structure and a series of drugs synthesized with it as intermediates, it can treat neurology and psychosis It has become an important pharmaceutical intermediate with potential research value. There are not many studies on this compound abroad, and there is no complete preparation method for the synthesis of this organic compound; there is no report on its synthesis in China. In view of this fact, the present invention elaborates the whole preparation process in detail: using dicyclopentadiene as raw material, the target product is finally obtained through cracking, Diels-Alder reaction and Grignard reaction in sequence. Contents of the invention [0003] The object of the present invention is to provide a kind of preparation met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C33/34C07C29/143
Inventor 谢宇胡金刚李明俊贾杰魏娅
Owner NANCHANG HANGKONG UNIVERSITY
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