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Composite gel suppository

A technology for compound gel suppositories and gel suppositories, which are applied in the directions of suppository delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc., can solve the problems of storage and irritation, achieve no residue and toxic side effects, and improve curative effect. , The effect of preparation stability

Inactive Publication Date: 2009-09-09
大连永兴生物医药孵化器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings of fat matrix and water-soluble matrix suppositories that are not conducive to storage and greater irritation, the invention provides a composite gel suppository

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] In suppositories Xiaomi suppository 1000g for the treatment of vaginal diseases:

[0016] (1) 200g sodium carboxymethylcellulose, 55g carbomer, and 240g polyvinyl alcohol are mixed evenly;

[0017] (2) Add 30g of glycerin, 15g of Tween-80, and 2000ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare a composite gel matrix;

[0018] (3) While stirring, slowly pour 460g of Xiaomi medicine powder into (2), after stirring evenly, the raw material of Xiaomi medicine suppository paste is obtained;

[0019] (4) When the temperature of the suppository raw material (3) drops to 45°C, it is injected into a mold for molding, and after cooling and solidifying, a hollow thin-shell suppository is obtained.

Embodiment 2

[0021] In suppositories 1000g of elemene for the treatment of cervical cancer diseases:

[0022] (1) 250g sodium carboxymethylcellulose, 100g chitosan, 500g polyvinyl alcohol are mixed uniformly;

[0023] (2) Add 80g of glycerin, 15g of Tween-80, and 2000ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare a composite gel matrix;

[0024] (3) While stirring, slowly pour 55g of elemene medicinal liquid into (2), after stirring evenly, obtain the pasty raw material of treating cervical cancer disease elemene;

[0025] (4) When the temperature of the suppository raw material (3) drops to 45°C, it is injected into a mold for molding, and after cooling and solidifying, a hollow thin-shell suppository is obtained.

Embodiment 3

[0027] In the preparation of musk hemorrhoidal suppositories 1000 g for the treatment of hemorrhoidal diseases:

[0028] (1) Mix 200g sodium carboxymethylcellulose, 100g sodium alginate, and 470g polyvinyl alcohol;

[0029] (2) Add 50g of glycerin, 15g of Tween-80, and 2000ml of deionized water into (1), and fully stir at a temperature of 50°C to 90°C to prepare a composite gel matrix;

[0030] (3) while stirring, slowly pour 165g musk hemorrhoid medicine into (2), after stirring evenly, make the paste raw material for treating hemorrhoid disease musk hemorrhoid medicine suppository;

[0031] (4) When the temperature of the suppository raw material (3) drops to 45°C, it is injected into a mold for molding, and after cooling and solidifying, a hollow thin-shell suppository is obtained.

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Abstract

The invention relates to a composite gel suppository, which is characterized in that sodium carboxymethyl cellulose is compounded with other gels to form a suppository base. The suppository has a hollow thin shell shape. The composite gel suppository has the following advantages that: 1, the suppository has the function of hemostasis; 2, the suppository has the function of inhibiting fungus growth; 3, a preparation of the suppository is more stable; 4, the pharmaceutical ingredients of the suppository can be released slowly and lastingly to improve the curative effect; 5, the suppository is convenient to use because the gel suppository can absorb water (tissue fluid) quickly to expand and is dissolved in anus, vagina or uterus, nasal cavity and auditory meatus to generate bio-adhesion so that the gel suppository is adhered to cavities and meatuses and the medicinal liquid of the suppository is not easy to flow out without generating overflow, thus an obstructing object is unnecessary to be used in the vagina or the anus; 6, the gel suppository does not have pungency; and 7, the suppository is biodegradable in a body without residues and toxic side effects, and is easier to be accepted by a patient under the condition of enhancing curative effect.

Description

technical field [0001] The invention relates to a composite gel suppository capable of carrying multiple medicines, which is composed of sodium carboxymethyl cellulose and other gels to form a suppository base. The suppository is in the shape of a hollow thin shell. Background technique [0002] Suppository bases are generally divided into fatty bases and water-soluble bases. Water-soluble matrices are generally considered slightly more irritating than aliphatic matrices, which are widely used. However, suppositories with aliphatic bases soften or melt at body temperature. Therefore, during preparation, their melting points need to be adjusted below human body temperature. Such a suppository has a storage condition problem, and the suppository needs to be stored at a temperature of 20° C. to 30° C. Since the lipid has a tendency to flow downward after melting, the drug solution overflows, which also affects part of the curative effect. The solution is to plug the barrie...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K47/38
Inventor 冯伯智滕锡山
Owner 大连永兴生物医药孵化器有限公司
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