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Micro emulsion drug carrying system and manufacturing method thereof

A drug-carrying system and microemulsion technology, which is applied in the fields of pharmaceutical formulation, emulsion delivery, and medical preparations containing active ingredients, etc., can solve the problems of large amount of emulsifier used and damage to the body, and achieve good stability and prevent toxicity , Prescription simple effect

Active Publication Date: 2009-09-09
CHONGQING LUMMY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently developed microemulsion drug-loading system also has disadvantages: (1) the amount of emulsifier used is large, which will cause harm to the body

Method used

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  • Micro emulsion drug carrying system and manufacturing method thereof
  • Micro emulsion drug carrying system and manufacturing method thereof
  • Micro emulsion drug carrying system and manufacturing method thereof

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preparation example Construction

[0017] The preparation method of the microemulsion drug-loading system of the present invention is completed by the following steps:

[0018] A, prepare materials by the weight ratio of medicinal oil: emulsifier: co-emulsifier: sodium chloride: water=1~25: 5~20: 5~25: 1~20: 50~85;

[0019] b. Mix the emulsifier and co-emulsifier evenly, add medicinal oil, and stir to obtain solution A;

[0020] c. After adding sodium chloride to solution A, add water and stir to form a microemulsion; or add solution A to sodium chloride aqueous solution and stir to form a microemulsion. Then transfer it to a dialysis bag, and repeatedly dialyze with physiological saline until the sodium chloride content is 0.85-0.9%.

[0021] In specific implementation, fat-soluble drugs can be added to the microemulsion drug-loading system of the present invention to obtain drug-loaded microemulsions. Its drug loading is 0.01-5%.

[0022] A specific embodiment of the present invention is to add propofol as...

Embodiment 1

[0024] Example 1 Preparation of microemulsion drug-carrying system of the present invention

[0025] Weigh 2g of polyene phosphatidylcholine, add 10g of glycerin, stir at 60°C to disperse polyene phosphatidylcholine, add 8g of Tween-80, stir, then add 2g of soybean oil, stir well, then add 17% chlorine 78 g of sodium chloride solution was stirred at 60° C. for 4 hours to obtain a transparent microemulsion with opalescence. The microemulsion was put into a dialysis bag with a molecular weight cut off of 5000, and the normal saline was dialyzed repeatedly, filtered with a 0.22 μm microporous membrane, and the average particle size of the microemulsion was determined to be 64 nm by dynamic light scattering.

Embodiment 2

[0026] Embodiment 2 Preparation of microemulsion drug-carrying system of the present invention

[0027] Weigh 2g of polyene phosphatidylcholine, add 10g of glycerin, stir at 60°C to disperse polyene phosphatidylcholine, add 10g of Tween-80, stir, then add 2g of soybean oil, stir well, then add 17% chlorine 76 g of sodium chloride solution was stirred at 60° C. for 4 hours to obtain an opalescent transparent microemulsion. The microemulsion was put into a dialysis bag with a molecular weight cut-off of 5000, repeatedly dialyzed with physiological saline, filtered with a 0.22 μm microporous membrane, and the average particle size of the microemulsion was determined to be 71 nm by dynamic light scattering.

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Abstract

The invention relates to a micro emulsion drug carrying system and a manufacturing method thereof, belonging to the field of pharmacy. The first technical problem the invention is intended to solve is to provide a micro emulsion drug carrying system without phase variation in the process of dilution. Proportioning by weight of the components of the system is medicated oil: emulsifier: assisting emulsifier; sodium chloride: water is equal to 1-25:5-20:5-25:1-20:50-85. The system features simple prescription, dosage of the emulsifier within the prescribed limit, the capacity to effectively prevent generation of toxicity, acrimony and hemolytic reaction; what is more, the system has good stability and no phase variation in the process of dilution, which is of great significance.

Description

technical field [0001] The invention relates to a microemulsion drug loading system and a preparation method, belonging to the field of pharmacy. Background technique [0002] Dissolving poorly water-soluble drugs in aqueous solutions in an appropriate manner to obtain preparations suitable for human use is a major technical problem in the research of drug-loading systems. Early studies have proved that the toxicity of poorly soluble drugs after they are prepared into aqueous solutions does not come from the drug itself, but from the carrier used to dissolve the drug. For poorly soluble drugs, the goal of pharmacy research is to improve the solubility of drugs, avoid the toxicity of solvents, and improve the safety of drugs. Many drugs with significant curative effect have limited their clinical use due to their poor solubility in water. For these drugs, oil-in-water (O / W) emulsions are often prepared, and the prescription can also be adjusted to achieve the desired concen...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/44A61K31/05A61K31/337
Inventor 唐小海邱宇宋鑫谢永美
Owner CHONGQING LUMMY PHARMA
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