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Use of isoliquiritigenin in preparation of auxiliary therapeutic medicine for tumor radiation therapy

A technology of isoliquiritigenin and medicine, which is applied in the field of medicine to reduce the symptoms of tissue damage, prolong the period of disease-free survival, and improve the quality of life

Active Publication Date: 2009-09-09
INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of isoliquiritigenin on tumor radiotherapy has not been reported so far

Method used

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  • Use of isoliquiritigenin in preparation of auxiliary therapeutic medicine for tumor radiation therapy
  • Use of isoliquiritigenin in preparation of auxiliary therapeutic medicine for tumor radiation therapy
  • Use of isoliquiritigenin in preparation of auxiliary therapeutic medicine for tumor radiation therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Attenuation and synergism of isoliquiritigenin on tumors irradiated by X-rays

[0022] 1.1 Experimental materials

[0023] Isoliquiritigenin was purchased from Jiangxi Bencao Tiangong Technology Co., Ltd., with a purity of 99.8% (as determined by HPLC). The Lewis lung cancer cell line was purchased from the China Center for Type Culture Collection (Wuhan University Collection Center), and inoculated into the right axilla of C57BL / 6 mice for subcutaneous passage.

[0024] 1.2 Experimental method

[0025]The tumor-bearing passage mice were sacrificed by cervical dislocation and fixed on the board. Disinfect animal skin with iodine tincture and alcohol, cut the skin, select tumor tissue with good tumor growth, no necrosis or liquefaction, add sterile saline, use a tissue homogenizer to make a cell suspension containing about 30 million / ml, and 120 C57BL / 6 mice were subcutaneously inoculated with 0.2 ml of the above tumor cell suspension in the inguinal part of...

Embodiment 2

[0045] Example 2: Synergistic and attenuating effect of isoliquiritigenin on tumors irradiated with heavy ions

[0046] 2.1 Experimental materials: Isoliquiritigenin, purchased from Jiangxi Bencao Tiangong Technology Co., Ltd., with a purity of 99.8% (as determined by HPLC). U14 cervical cancer cell line was purchased from Beijing Institute of Materia Medica, Chinese Academy of Medical Sciences, and inoculated into the peritoneal cavity of Kunming mice for preservation.

[0047] 2.2 Experimental method:

[0048] Take the passage mice that have been inoculated with U14 cervical cancer ascites for 7 days, and after disinfecting the abdomen, take milky white ascites with a sterile syringe, and add 5 times the volume of normal saline for injection to dilute. 120 mice were inoculated subcutaneously with 0.2 ml of the above-mentioned tumor cell suspension after disinfecting the skin of the inguinal region of the right posterior ramus. On the 10th day after tumor inoculation, selec...

Embodiment 3

[0066] Example 3: Synergistic effect of isoliquiritigenin on gamma-ray radiotherapy

[0067] 3.1 Experimental materials

[0068] Isoliquiritigenin was purchased from Jiangxi Bencao Tiangong Technology Co., Ltd., with a purity of 99.8% (as determined by HPLC). The H22 liver cancer cell line was purchased from Beijing Institute of Materia Medica, Chinese Academy of Medical Sciences, and was inoculated in the peritoneal cavity of Kunming mice for preservation.

[0069] 3.2 Experimental method:

[0070] Take the passaged mice that have been inoculated with H22 liver cancer ascites for 7 days, and after disinfecting the abdomen, take milky white ascites with a sterile syringe, and add 5 times the volume of normal saline for injection to dilute. 120 mice were inoculated subcutaneously with 0.2 ml of the above-mentioned tumor cell suspension after disinfecting the skin of the inguinal region of the right posterior ramus. On the 10th day after tumor inoculation, mice with a tumor m...

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Abstract

The invention belongs to the technical field of medicine and in particular relates to a new use of isoliquiritigenin that is an isoflavone compound extracted from glycyrrhiza plants, in particular to the use in the preparation of an auxiliary therapeutic medicine for tumor radiation therapy. The isoliquiritigenin is used for the preparation of a medicine for alleviating untoward effects of malignant tumor radiation therapy and enhancing the treatment effect of the malignant tumor radiation therapy, thereby providing a new optional auxiliary therapeutic medicine for the malignant tumor radiation therapy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new application of isoflavone compound extracted from licorice plants—isoliquiritigenin, in particular to its application in the preparation of adjuvant medicine for tumor radiotherapy. Background technique [0002] Malignant tumors have become the leading cause of death in the global population. With the advancement of science, the existing treatment methods for malignant tumors—surgery, chemotherapy, and radiation therapy—have made considerable progress, and the survival rate of patients has gradually increased. However, most malignant tumors, especially malignant solid tumors, cannot be completely cured and become malignant tumors. The main reason for the high death rate. [0003] Radiation therapy is one of the basic means of tumor treatment, and its application history has been more than one hundred years. Among all cured cancer patients, the relative contri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P35/00
Inventor 张红王振华李宁
Owner INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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