Chinese herbal compound for preventing and curing fatty liver

A technology for fatty liver and traditional Chinese medicine, which is applied in the directions of pharmaceutical formulations, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of difficult quality assurance, and achieve the effect of affirming the effect, improving the therapeutic effect, and being easy to obtain.

Inactive Publication Date: 2011-06-29
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prevention and treatment of fatty liver with traditional Chinese medicine has attracted people's attention, but there are many traditional Chinese medicine prescriptions, generally at least 5-10 traditional Chinese medicines, and as many as 10 traditional Chinese medicines, and most of them are self-purchased and self-decocted, so the quality is difficult to guarantee

Method used

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  • Chinese herbal compound for preventing and curing fatty liver
  • Chinese herbal compound for preventing and curing fatty liver
  • Chinese herbal compound for preventing and curing fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Using the mouse fatty liver model, observing the liver index and the content of triglyceride (TG) in the liver tissue, using orthogonal experiments to screen out the effective prescription of traditional Chinese medicine:

[0025] Experimental animals: healthy Kunming mice, clean grade (SPF grade), male, kept in separate cages, free to eat and drink every day, in the experimental environment (clean and dust-free, fresh air, temperature at 18-22°C, relative humidity at 50- 60%, noise below 85 decibels) to adapt to 6d. Feed the high-fat diet (2% cholesterol, 10% lard, 0.2% propylthiouracil, 0.5% sodium cholate) to the mice subsequently, and the rest are basal feed (the basal feed is processed by Guangdong Experimental Animal Center, including 6.4% Crude ash, 4.9% crude fat, 4.6% crude fiber, 19.1% crude protein, 8.3% moisture, 1.17% calcium, 0.63% phosphorus, the above components are all in weight percent), weighed each time The weight of the feed was used to ensure that...

Embodiment 2

[0068] Using mice with hyperlipidemic fatty liver as a model, the prevention and treatment effect of traditional Chinese medicine GST on fatty liver was verified, and the optimal dosage was determined.

[0069] Experimental animals: healthy Kunming mice, clean grade (SPF grade), male, kept in separate cages, free to eat and drink every day, in the experimental environment (clean and dust-free, fresh air, temperature at 18-22°C, relative humidity at 50- 60%, noise below 85 decibels) to adapt to 6d. Then the mice were fed with high-fat feed, and the feed weight was weighed each time to ensure that the average food intake of each mouse was consistent, and the control group was fed with basal feed.

[0070] Method of administration: Chinese medicine free decoction granules are mixed with double distilled water into different doses of Chinese medicine compound GST solution of the present invention: high dose (Ginseng, Panax notoginseng, Gastrodia elata final concentration is 130mg / ...

Embodiment 3

[0092] Using mice with hyperlipidemic fatty liver as a model, the therapeutic effect of traditional Chinese medicine GST on fatty liver was verified.

[0093] Experimental animals: healthy Kunming mice, clean grade (SPF grade), male, kept in separate cages, free to eat and drink every day, in the experimental environment (clean and dust-free, fresh air, temperature at 18-22°C, relative humidity at 50- 60%, noise below 85 decibels) to adapt to 6d. Then the mice were fed with high-fat diet, and the weight of the feed was weighed each time to ensure that the average food intake of each mouse was consistent. The control group was fed with basal diet. After 12 weeks, the mice were randomly divided into 4 groups:

[0094] Group 1: Control group

[0095] Group 2: high fat group

[0096] Group 3: normal diet group

[0097] Group 4: GST administration group

[0098] The high-fat group continued to be fed with high-fat feed, and the rest of the groups were fed with basic feed. In t...

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Abstract

The invention discloses a Chinese herbal compound for preventing and curing hyperlipidemia fatty liver, which consists of the following components based on the weight ratio: 0.1-50g of ginseng, 0.1-50g of panax notoginseng and 0.1-50g of gastrodin. By adopting a conventional processing method, the Chinese herbal compound can be manufactured into oral liquid, capsules or tablets. The Chinese herbal compound intimately combines the current requirement of fatty liver cure and good prospect of Chinese herbal application, lays a favorable foundation for developing modern prepared Chinese herb for curing the fatty liver with independent intellectual property rights, has an important significance in improving the cure effect of the fatty liver, large market popularization and application value, less medicine component prescription, easy acquisition, convenience, cheapness, positive effect, good market prospect, and a certain practical significance for promoting the modernization of Chinese herb.

Description

technical field [0001] The invention belongs to the field of research, development and utilization of traditional Chinese medicine, in particular to a compound traditional Chinese medicine for preventing and treating fatty liver. Background technique [0002] Fatty liver is a liver disease caused by one or more reasons and the pathological change is the accumulation of liver lipids (usually triglycerides). In recent years, with the improvement of people's living standards, people's living habits and diet structure are constantly changing, and the incidence of fatty liver is increasing year by year, which has become a common hidden danger that seriously endangers human health. Epidemiological studies have shown that the incidence of fatty liver in my country is 5.2% to 11.4%. The more developed the economy of the region, the higher the incidence, and the age of onset is younger. Fatty liver has become a disease after viral hepatitis in my country. The 2nd most common liver di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P1/16
Inventor 陆大祥胡巢凤戚仁斌
Owner JINAN UNIVERSITY
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