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Micropore structure of microplate strip

A microporous structure and microporous technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of increasing the surface area to volume ratio or solution depth, not suitable for luminescent immunodetection, increasing the reaction rate and light absorption rate, etc.

Active Publication Date: 2009-09-16
XIAMEN XIANMING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A name disclosed in the Chinese utility model patent is Improving the immunoassay response Response rate, sensitivity instrument (ZL 200620046752.2), the design of this patented product is to increase the surface area to volume ratio or the solution depth by reducing the inner diameter of the existing circular micropores, thereby increasing the reaction rate and light absorption rate, and its structure involves additional fixed accessories , the operation is cumbersome, and the design is not suitable for luminescence immunoassay

Method used

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  • Micropore structure of microplate strip
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  • Micropore structure of microplate strip

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment one (enzyme-linked immunoassay test is used):

[0024] like figure 1 , figure 2 and Figure 5 The microporous structure of the microporous strip shown contains a circular microhole 1 with a standard height of 12mm and an inner diameter 2R of 6.8mm, on the ring wall 2 of the lower half (ie 6mm height) of the microwell 1 16 convex racks 3 with the same shape and proportion are arranged in equal parts. The convex rack 3 is a triangular prism with an arc surface on one side. The ring wall 2 of 1; the convex rack 3 is integrally formed with the microhole 1, the convex rack 3 is perpendicular to the bottom surface of the microhole 1, the height of the convex rib 6 of the convex rack 3 is 4mm, and the top of the convex rack 3 is an oblique sector 4. The projection formed by the convex rack 3 on the bottom of the microhole 1 is fan-shaped 5, and the distance between the convex rib 6 and the center of the microhole 1 is r=2.2mm.

[0025] The convex rack 3 used i...

Embodiment 2

[0045] Embodiment 2 (for luminescence immunoassay):

[0046] like image 3 , Figure 4 and Figure 5The microwell structure of the microwell strip shown, the microwell 1 of the microwell strip with convex racks protruding inward for luminescent immunoassay, and the ring wall 2 in the lower half (ie 6mm height) of the microwell 1 16 convex racks 3 with the same shape and proportion are arranged on the upper part. The convex rack 3 is a quadrangular prism with an arc surface. The bottom of the convex rack 3 is connected to the bottom of the microhole 1. The ring wall 2 of the hole 1; the convex rack 3 is integrally formed with the microhole 1, the convex rack 3 is perpendicular to the bottom surface of the microhole 1, the rib of the convex rack 3 is a point, and the distance between the convex rib 6 and the center of the microhole 1 is r =1.5mm, the rib height in this embodiment is 0mm, at this time the convex rack 3 is a quadrangular prism, with an area-to-volume ratio.

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Abstract

A micropore structure of a microplate strip comprises round micropore in a standard format. A plurality of convex tooth strips in the same shape and proportion are arranged in an equant manner on the annular wall of the lower part of the inside of each micropore, the bottoms of the convex tooth strips are connected with the bottom of the micropore, and the sides of the convex tooth strips are connected with the annular wall of the micropore. The surface area formed by the convex tooth strips convex inward is much greater than the surface area of the inner cavity of the conventional micropore, so the solid-liquid interface of the same volume of reaction solution has a greatly increased reaction area that is favorable for complete immunoreactions, and luminous reaction or enzyme catalyzed reaction and contributes to the great reduction in time for reaching reaction equilibrium, improvement in detection flexibility and reduction in time for detection; the convex tooth strips improves both the reaction area and an optical signal compared with the conventional micropore structure and increases the strength of the detection optical signal of a luminometer; the top parts of the convex tooth strips are inclined sectors which are capable of reflecting the optical signal of the luminous reaction upward to a probe of the luminometer, and compared with the reaction of the micropore side wall of the conventional microplate strip, the optical signal of the probe is strengthened considerably and the flexibility of a method is improved.

Description

technical field [0001] The invention relates to a microporous strip used in biological science research or medical diagnosis, in particular to a microporous structure of the microporous strip which can greatly increase the immunological detection reaction area and improve the reaction speed and sensitivity of the immunological detection. Background technique [0002] Since the invention of enzyme-linked immunosorbent assay (ELISA), it has been widely used in life sciences, medical research and medical diagnostic activities; The quality of reagents has improved significantly. Today, microwell strip-based ELISA and chemiluminescence immunoassays are widely used. [0003] Solid phase material is one of the important factors to determine the quality of ELISA products. The most commonly used today are polystyrene microwell strips, available in standard formats of 96 and 384 wells, for ELISA or luminescent immunoassays. At present, the main problems of polystyrene microporous s...

Claims

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Application Information

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IPC IPC(8): G01N33/543G01N33/545
Inventor 徐恩良
Owner XIAMEN XIANMING BIOTECH CO LTD
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