Method for preparing lubricating coating with strong stability on surface of medical polyurethane material

A technology with strong stability and lubricity, applied in coatings, medical science, prostheses, etc., can solve problems such as weak coatings and low grafting efficiency, and achieve simple and easy preparation methods, low friction coefficients, and high stability Good results

Inactive Publication Date: 2009-12-30
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for preparing a lubricating coating with strong stability on the surface of medical polyurethane materials. This new method can effectively solve the problems of low grafting efficiency and weak coating, and has the advantages of simple process, easy control, Easy to enlarge and other features

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Acrylic acid is a hydrophilic polymer monomer, and N,N-dimethylacrylamide is a surface coating preparation of a strong water-absorbing hydrogel precursor

[0039] Take 10g of clean polyurethane catheter and activate it in 20mg / L ozone for 30min. 3 g of analytically pure acrylic acid, 97 g of distilled water and 0.5 g of castor oil were respectively added to a 200 ml three-necked flask. Under the condition of 50°C oil bath and nitrogen protection, magnetic stirring was carried out for 300 minutes. Take the newly reacted polyurethane catheter, wash it in pure water at 70°C for 18 hours, replace the distilled water at least 10 times, then ultrasonically clean it in ethanol for 30 minutes, and dry it in vacuum at 60°C to constant weight. The sample was then activated in 30 mg / L ozone for 40 min. Then add 3g of analytically pure N,N-dimethylacrylamide, 97g of distilled water and 0.5g of castor oil into a three-necked flask for reaction. The conditions were 50°C ...

Embodiment 2

[0041] Embodiment 2 Methacrylic acid is a hydrophilic polymer monomer, and N,N-dimethylacrylamide is a surface coating preparation of a strong water-absorbing hydrogel precursor

[0042] Take a clean 10g polyurethane catheter and activate it in 20mg / L ozone for 50min. 0.5 g of analytically pure methacrylic acid, 3 g of analytically pure N,N-dimethylacrylamide, 95 g of ethyl acetate and 0.5 g of castor oil were respectively added to a 200 ml three-necked flask. The reaction conditions were 12 hours of magnetic stirring in an oil bath at 50° C. under nitrogen protection. After the reaction, the catheter was washed in pure water for 24 hours at 80°C, and distilled water was replaced at least 15 times, then ultrasonically cleaned in ethanol for 1 hour, vacuum-dried at 60°C to constant weight, and stored for use.

[0043] When the prepared catheter is wet, the coefficient of dynamic friction decreases from 0.48 to 0.52, and the surface lubricity is obviously improved. Repeated pu...

Embodiment 3

[0044] Example 3 Acrylic acid is a hydrophilic polymer monomer, and vinylpyrrolidone is a surface coating preparation of a strong water-absorbing hydrogel precursor

[0045] Take a clean 10g polyurethane catheter and perform plasma activation at a power of 50W and an oxygen flow rate of 50mL / min for 15min. 3 g of analytically pure acrylic acid, 97 g of distilled water and 0.5 g of ethylene glycol were added to a 200 ml three-necked flask. In an oil bath at 50° C. under nitrogen protection, magnetic stirring was performed for 2 h. Take the newly reacted polyurethane film, wash it in pure water at 70°C for 18 hours, replace the distilled water at least 10 times, then ultrasonically clean it in ethanol for 30 minutes, and dry it in vacuum at 60°C until constant weight. The sample was then activated in 30 mg / L ozone for 40 min. The sample was then added to a container with a concentration of 10 mg / L vinylpyrrolidone monomer gas flowing for 2 hours. After the reaction, the cathe...

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Abstract

The invention discloses a method for preparing a lubricating coating with strong stability on the surface of a medical polyurethane material, comprising the following steps of: step 1, pretreating the medical polyurethane material so as to obtain positions with proper surface roughness and reaction activity; step 2, putting the polyurethane polymer material pretreated in the step 1 into a gas phase system of reaction solution or solute for grafting reaction; and step 3, cleaning and drying the reaction products from the step 2. The method can be widely used for preparing medical polymer materials and high-lubricity coating materials on the surface of medical instruments.

Description

technical field [0001] The invention belongs to the field of surface functionalization of medical polymer materials, and specifically relates to a preparation method for synthesizing a lubricating coating with strong stability on the surface of medical catheters, guide wires and stents and other medical polymer materials. Background technique [0002] Polyurethane (PU) has been widely used in the field of medical materials since it was invented by Bayer. Medical polyurethane has unique properties not found in other biomedical materials, such as biocompatibility, chemical characteristics, and processing characteristics, and has become an ideal choice for many medical applications. Especially when medical devices need to have complex mechanical properties and good biocompatibility at the same time, polyurethane is the most commonly used and the best choice, for example, PU is used for coatings of interventional devices, artificial catheters, interventional balloons, cardiovasc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/06A61L31/08A61L31/06A61L27/28A61L27/18
Inventor 顾宁周雪锋江筱莉张天柱
Owner SOUTHEAST UNIV
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