Hematology linearity control composition system and method of use

A compositional and linear technology, applied in scientific instruments, biological tests, reference solutions, etc., can solve problems such as time-consuming and measurement errors
CN101535804AActive Publication Date: 2009-09-16BECKMAN COULTER INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BECKMAN COULTER INC
Publication Date
2009-09-16

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Abstract

A linearity control system includes a series of linearity control compositions; each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2x103 to 800x103 analogs per microliter, and the concentration of the white blood cell analogs in at least one control composition is greater than 120x103 analogs per microliter. The stabilized red blood cells facilitate mono-dispersion of the white blood cell analogs in the suspension medium by gently mixing. The control compositions further include platelet analogs, or additionally include reticulocyte and / or nucleated red blood cell analogs. The linearity control system allows the verification of the reportable measurement range and linearity of the measurements of hematology analyzers for white blood cells, red blood cells and platelets in extended concentration ranges.
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Description

[0001] Cross References to Related Applications

[0001] This application claims priority under 35 U.S.C. § 119(e) to U.S. Provisional Patent Application Serial No. 60 / 865,661, filed November 14, 2006, which is hereby incorporated in its entirety as a reference. technical field

[0002] The present invention relates to a linear reference control composition and a linear control system capable of verifying the reportable assay range and linearity of measurement of white blood cells, red blood cells and platelets by a hematology analyzer over an extended concentration range. Background technique

[0003] In clinical hematology, quality control has always been a necessary and routine procedure. Accuracy in various types of blood cell counts depends in part on the availability of adequate control products and the method by which the control products are used. With the many models of equipment currently available for particle counting, quality control through the use of control...

Claims

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