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Degradable blood vessel casting agent

A casting and blood vessel technology, which is applied in the field of bioengineering, can solve the problems of difficult preparation of tissue engineering scaffolds from blood vessel casting agents, and achieve the effects of good mechanical and physical properties, good compatibility, and good biocompatibility

Inactive Publication Date: 2011-10-19
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a degradable casting agent to meet the needs of preparing tissue engineering scaffolds with physiological vascular network structures, and to overcome the problems that commonly used vascular casting agents are difficult to be directly used to prepare tissue engineering scaffolds.

Method used

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  • Degradable blood vessel casting agent
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Examples

Experimental program
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Effect test

Embodiment 1

[0019] Take 1.0 gram of poly D, L lactic acid with a molecular weight of 390,000, put it in a beaker, add 10 ml of ethyl acetate, and after the poly D, L lactic acid is completely dissolved, the polylactic acid casting agent is obtained. Can be used as a vascular cast.

[0020] Use this casting agent to cast liver blood vessels in rats, then cut off the liver and let it dry naturally at room temperature, then put it in 25% hydrochloric acid solution for 3 days, wash it slowly with running water, remove cells and connective tissue, and then wash it with soap After soaking in water for 1 day, a milky white rat liver vascular tree model is obtained. its photo see figure 1 .

Embodiment 2

[0022] Take 2.0 grams of polyglycolic acid and place it in a beaker, add 10 ml of acetone, and after the polyglycolic acid is completely dissolved, the polyglycolic acid casting agent is obtained. Can be used as a vascular cast.

Embodiment 3

[0024] Take 0.5 g of poly D, L lactic acid and 0.5 g of polyglycolic acid and put them in a beaker, add 5 ml of chloroform, 1,4 dioxane, after the poly D, L lactic acid and polyglycolic acid are completely dissolved, the poly D, L lactic acid and polyglycolic acid casting agents can be used as vascular castings.

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Abstract

The invention relates to a degradable blood vessel casting agent. The casting agent consists of casting material and an organic solvent. 1ml of the casting agent contains 0.05 to 0.5g of the casting material. The casting material is one of polylactic acid, polyglycollic acid and polycaprolactone or the combination of any two; and the organic solvent is acetone, ethyl acetate, chloroform or 1,4-dioxane. The preparation and application process of the casting agent is simple and easily operated. The concentration of the casting agent is timely regulated as required; and the casting agent can be used for feeding a cast many times during casting so as to maintain the natural form of a blood vessel maximally. After being injected into the blood vessel or a blood vessel die, the casting agent can be completely solidified through a plurality of drying methods; and then a blood vessel cast is obtained after the corrosive removal of tissues and cleaning or after opening the blood vessel die. The blood vessel cast prepared from the casting agent has certain toughness and mechanical strength. The casting agent has good biocompatibility, easy molding, and easy percolation and dissolution, and is suitable for the study on the preparation of a hepatic tissue engineering support with a physiological shape blood vessel network.

Description

technical field [0001] The invention relates to a degradable vascular casting agent. It belongs to the technical field of bioengineering. Background technique [0002] Vascular casting technology is a specialized technique for making anatomical specimens, which is widely used in making specimens of vascular network models in animals and human organs, and has high application value in medical teaching and scientific research. At present, the combination of this production technology and computer is used to synthesize a three-dimensional image of the vascular network for the research field of tissue engineering scaffolds. However, the application of the three-dimensional image of the blood vessel network obtained by this method to the preparation of tissue engineering scaffolds still requires special molding equipment. It can be completed, so it is limited due to the complexity of the research process and high cost. [0003] The cast agent is injected into the blood vessel, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04G09B23/28
Inventor 万涛李世普贺建华文和赵飞
Owner WUHAN UNIV OF TECH