Application of 5' nucleotide in preparation of medicines and health-care foods for reducing blood fat

A technology for blood lipid-lowering drugs and health food, which is applied in the field of 5' nucleotide products and their new uses, health food, and preparation of blood-lipid-lowering drugs, and can solve the problems that nucleotides have not been reported.

Inactive Publication Date: 2009-10-21
珍奥集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, as nutritional factors with immunomodulatory effects, many countries including China have allowed the addition of nucleotides to infant formula milk powder, but there are no reports on the role of nucleotides in regulating blood lipids

Method used

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  • Application of 5' nucleotide in preparation of medicines and health-care foods for reducing blood fat
  • Application of 5' nucleotide in preparation of medicines and health-care foods for reducing blood fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] Example: 5' Nucleotide Assisted Blood Lipid Lowering Experimental Research

[0011] 1. Materials and methods

[0012] 1. Sample: 5' nucleotide (5'AMP: 5'CMP: 5'GMPNa 2 : 5'UMPNa 2 =22.8∶26.6∶30.2∶20.4), production process: heat denaturation of ribonucleic acid (RNA) with a purity of 90% → enzymatic hydrolysis with nuclease P1 → ultrafiltration → adsorption on anion resin → stepwise elution → nanofiltration desalination → Thin film concentration → carbon powder decolorization → crystallization → drying.

[0013] 2. Experimental animals: 60 healthy and clean male SD rats, weighing 160-200g, provided by the Experimental Animal Center of Peking University Health Science Center. , The temperature range of the feeding environment is 25±1°C, and the relative humidity is 50% to 60%RH.

[0014] 3. Main instruments and reagents: Olympus AU400 automatic biochemical analyzer (Japan). Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (...

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Abstract

The invention relates to an application of 5' nucleotide in preparation of medicines and health-care foods for reducing blood fat. The nucleotide is 5' nucleotide mixture which takes ribonucleic acid (RNA) as raw material, produced by enzymic degradation, has the purity of more than 99%, and is prepared by mixing 5' AMP, 5' CMP, 5' GMPNa2 and 5' UMPNa2 according to the mixture ratio of 22.8:26.6:30.2:20.4. Being proved by animal experiments, the 5'nucleotide can reduce the levels of hyperlipidemia model rat serum total cholesterol and triglyceride and has the function of assisting to reduce the blood fat.

Description

technical field [0001] The invention relates to a 5' nucleotide product and its new application, specifically, the use of ribonucleic acid as a raw material to produce 5' nucleotides through enzymatic degradation in the preparation of blood lipid-lowering drugs and health food. It belongs to the field of medicine and food health care. Background technique [0002] Hyperlipidemia is a disease in which the concentration of one or more components in plasma lipids exceeds the normal upper limit due to lipid metabolism disorders in the body. Hyperlipidemia is the pathological basis of initiating and aggravating atherosclerosis, and is an independent risk factor for coronary heart disease, angina pectoris, myocardial infarction, cerebral infarction, renal damage and other arterial embolism diseases. In recent years, with the change of human diet and lifestyle, the prevalence of hyperlipidemia has been increasing, and it has become one of the global public health problems. The 20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61K31/7076A61K31/7072A61K31/7068A61P3/06A23L1/30C12P19/30A23L33/13
Inventor 李恕李勇董锋
Owner 珍奥集团股份有限公司
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