High-field asymmetric waveform ion mobility spectrometer with multi-layer plate structure

Abstract

The invention relates to a high-field asymmetric waveform ion mobility spectrometer with a multi-layer plate structure, which belongs to the device for analyzing and detecting biochemicals on site. The mobility spectrometer has a structure that a first gas channel and a second gas channel are formed by an upper base sheet, a middle base sheet and a lower base sheet; an ion source is arranged on the first gas channel; a separation electrode consists of an upper separation electrode and a lower separation electrode, which are respectively arranged on the upper base sheet and the lower base sheet. Electriferous sample ions enter the second gas channel under the action of a separation electric field, and also enter a mobility area for filtering separation under the action of pure carrier gas. The flow rates of the carrier gas in the ion source and the mobility area can be respectively regulated by the sample carrier gas and the pure carrier gas. The invention has the advantages that neutral molecules and the electriferous sample ions are separated before entering the mobility area, thereby avoiding the generation of molecular ion reaction in the mobility area; the flow rates of the carrier gas in the ion source and the mobility area can be regulated respectively, thereby improving the ionization efficiency of the ion source and the ion separation effect of the mobility area.

Description

technical field [0001] The invention relates to rapid determination of biochemical substances, belongs to the field of on-site analysis and detection, and is specifically a high-field asymmetric waveform ion mobility spectrometer with a multilayer flat structure. Background technique [0002] High-field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS, High-field Asymmetric Waveform Ion Mobility Spectrometry) is a biochemical substance detection technology gradually developed in the 1990s. It mainly uses the characteristics that the mobility of ions under high electric field will vary with the change of electric field strength to separate and detect different kinds of biochemical substances. The mobility coefficient K of ions under the condition of low electric field has nothing to do with the electric field strength. When the electric field strength reaches a certain value, the ion mobility coefficient K will change, and it will change with the electric field strength i...

AI Technical Summary

Problems solved by technology

In these two flat FAIMS, the ion source and the migration area are on the same gas path, and the carrier gas velocity of the ion source and the migration area cannot be adjusted separately, which reduces the overall performance of the FAIMS system.

[0007] New Mexico State University adopts figure 1 and figure 2 The flat plate FAIMS system with the structure shown in the figure separates the mixture of acetone and toluene. Due to the existence of molecular ion reactions, acetone and toluene cannot be completely separated in the experiment.

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