Compound antibacterial injection for livestock and preparation method thereof

An injection and compound technology, which is applied in the directions of antibacterial drugs, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problem that the stability of the injection is not good enough, the drug cannot be absorbed for a long time, and the curative effect of the drug is affected. To achieve the effect of prolonging the maintenance time of effective blood drug concentration, improving clarity, saving manpower and time

Active Publication Date: 2011-05-04
HENAN XINZHENGHAO BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the present compound sulfonamides and trimethoprim combined injection also has certain disadvantages, because there are still deficiencies in the type and dosage selection of auxiliary materials, the stability of the injection is not good enough, easy to crystallize and change color, and the medicine is in The residence time in the animal body is relatively short, and the drug cannot be absorbed for a long time, which affects the curative effect of the drug. It needs to be administered twice a day

Method used

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  • Compound antibacterial injection for livestock and preparation method thereof
  • Compound antibacterial injection for livestock and preparation method thereof
  • Compound antibacterial injection for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: formula is as follows:

[0022] Sulfamethoxine 10g

[0023] Trimethoprim 2g

[0024] N-Methylpyrrolidone 10g

[0025] Polyethylene Glycol-400 20g

[0026] Sodium hydroxide 1.0g

[0027] Disodium edetate 0.01g

[0028] Sodium metabisulfite 0.2g

[0029] Add water for injection to 100ml.

[0030] The preparation method comprises the following steps:

[0031] (1) Add polyethylene glycol-400 and N-methylpyrrolidone into the concentrated preparation tank, heat to 50°C, add trimethoprim, stir to dissolve, and pour into the thin preparation tank;

[0032] (2) Add 40ml of water for injection into the concentrated preparation tank, then add disodium edetate, sodium hydroxide, sulfamethoxine and sodium pyrosulfite, stir the solution until it is uniform, and then pour in the solution of step (1). in dilute tanks;

[0033] (3) After stirring the solution in the dilute preparation tank until it is completely uniform, add water for injection to make the volume ...

Embodiment 2

[0035] Embodiment 2: formula is as follows:

[0036] Sulfamethoxine 13g

[0037] Trimethoprim 2.5g

[0038] N-Methylpyrrolidone 8g

[0039] Polyethylene Glycol-400 30g

[0040] Sodium hydroxide 1.2g

[0041] Disodium edetate 0.015g

[0042] Sodium metabisulfite 0.3g

[0043] Add water for injection to 100ml.

[0044] The preparation method comprises the following steps:

[0045] (1) Add polyethylene glycol-400 and N-methylpyrrolidone into the concentrated preparation tank, heat to 55°C, add trimethoprim, stir to dissolve, and pour into the thin preparation tank;

[0046] (2) Add 30ml of water for injection into the concentrated preparation tank, then add disodium edetate, sodium hydroxide, sulfamethoxine and sodium pyrosulfite, stir the solution until it is uniform, and then pour in the solution of step (1). in dilute tanks;

[0047] (3) After stirring the solution in the dilute preparation tank until it is completely uniform, add water for injection to make the volum...

Embodiment 3

[0049] Embodiment 3: formula is as follows:

[0050] Sulfamethoxine 15g

[0051] Trimethoprim 3g

[0052] N-Methylpyrrolidone 5g

[0053] Polyethylene Glycol-400 40g

[0054] Sodium hydroxide 1.5g

[0055] Disodium edetate 0.02g

[0056] Sodium metabisulfite 0.5g

[0057] Add water for injection to 100ml.

[0058] The preparation method comprises the following steps:

[0059] (1) Add polyethylene glycol-400 and N-methylpyrrolidone into the concentrated preparation tank, heat to 60°C, add trimethoprim, stir to dissolve, and pour into the thin preparation tank;

[0060] (2) Add 20ml of water for injection to the concentrated preparation tank, then add disodium edetate, sodium hydroxide, sulfamethoxine and sodium pyrosulfite, stir the solution until it is uniform, and then pour in the solution of step (1). in dilute tanks;

[0061] (3) After stirring the solution in the dilute preparation tank until it is completely uniform, add water for injection to make the volume to 10...

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PUM

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Abstract

The invention provides a compound antibacterial injection for livestock. The formula includes: 10-15g of sulfamonomethoxine, 2-3g of trimethoprim, 5-10g of N-methylpyrrolidone, 20-40g of polyethylene glycol-400, 1.0-1.5g of sodium hydroxide, 0.01-0.02g of disodium ethylenediamine tetracetic acid, 0.2-0.5g of sodium metabisulfite and water for injection added to 100ml. Through optimized match of auxiliary material, the stability of the injection is good and the defects that the former injection of the type is unstable and prone to crystallize and discolor are overcome. Verified by stability test and examination, the injection can be stored for at least 24 months at normal temperature. The long half-life of the injection not only prolongs the holding time of effective blood concentration, but also reduces frequency for administration, saves human labor and time and relieves the stress reaction brought to sick livestock by frequent injection.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, relates to a compound antibacterial injection for veterinary use, and relates to a preparation method of the injection. Background technique [0002] In the production process of modern breeding industry, the degree of automation and intensification is increasing day by day. Once various diseases spread, it will cause disaster to the farm. Veterinary medicine is an important means of agricultural production. As the material basis of animal husbandry, the veterinary medicine industry The development and quality of veterinary drugs will be directly related to the healthy development of animal husbandry, the sustainable development of rural economy and the increase of farmers' income. In recent years, with the increase in international animal circulation and trade, various diseases have undergone new developments and changes, and many new diseases have emerged. The new serious disease h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61K47/34A61K47/22A61K47/18A61K47/04A61P31/04A61K9/08
Inventor 王祝义焦黎赵晓峰
Owner HENAN XINZHENGHAO BIO ENG
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