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Method for preparing chitosan or sodium alginate-modified carbon nanotube-targeted slow release carrier

A technology of sodium alginate and slow-release carrier, which is applied in the field of preparation of nano-medicine technology, can solve the problems of non-targeting and high toxicity of carbon nanotube carriers, and achieves simple and easy preparation methods, good water solubility, Controllable Effects

Inactive Publication Date: 2009-12-02
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] After searching the literature of the prior art, it was found that the article "Multiwalled carbonnanotube-doxorubicin supramolecular complexes for cancer therapeutics" published by Hanene Ali-Boucetta et al. The polyoxypropylene block copolymer Pluronic F127 was used to modify the multi-walled carbon nanotubes to improve their water solubility, and then Adriamycin was adsorbed on the multi-walled carbon nanotubes in a non-covalent manner, and the obtained carbon tubes The mycin complex is more toxic than pure doxorubicin, but the disadvantage is that the prepared carbon nanotube carrier is not targeted

Method used

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  • Method for preparing chitosan or sodium alginate-modified carbon nanotube-targeted slow release carrier
  • Method for preparing chitosan or sodium alginate-modified carbon nanotube-targeted slow release carrier
  • Method for preparing chitosan or sodium alginate-modified carbon nanotube-targeted slow release carrier

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Embodiment 1

[0030] Example 1. Single-walled carbon nanotubes (SWCNTs) prepared by chemical vapor deposition are used as the initial raw material. After acidification and truncation, chitosan or sodium alginate and folic acid are functionalized by non-covalent physical coating to the surface of single-walled carbon nanotubes, and adopt doxorubicin (DOX) as a model drug to obtain folic acid-targeted chitosan or sodium alginate-modified single-walled carbon nanotubes doxorubicin-targeted drug carrier, the specific steps are as follows :

[0031] Step (a): In 300 mL of 98% H with a volume ratio of 3:1 2 SO 4 and 65% HNO 3 Add 500 mg of single-walled carbon nanotube raw material to the mixed acid, sonicate for 24 hours in an ice-water bath at 0°C, filter with polytetrafluoroethylene microporous membrane with a pore size of Φ0.22 μm, and wash repeatedly with a large amount of deionized water until neutral, 50 After vacuum drying at ℃ for 24 hours, truncated single-walled carbon nanotubes wer...

Embodiment 2

[0039] Example 2, the single-walled carbon nanotubes (SWCNTs) prepared by chemical vapor deposition method are used as the initial raw material, and after acidification and truncation, chitosan or sodium alginate and folic acid are functionalized by non-covalent physical coating Go to the surface of single-walled carbon nanotubes, and use epirubicin (EPB) as a model drug to obtain folic acid-targeted chitosan or sodium alginate-modified single-walled carbon nanotubes doxorubicin-targeted drug carrier, specific steps as follows:

[0040] Step (a): In 300 mL of 98% H with a volume ratio of 3:1 2 SO 4 and 65% HNO 3 Add 500 mg of single-walled carbon nanotube raw material to the mixed acid, sonicate for 24 hours in an ice-water bath at 0°C, filter with polytetrafluoroethylene microporous membrane with a pore size of Φ0.22 μm, and wash repeatedly with a large amount of deionized water until neutral, 50 After vacuum drying at ℃ for 24 hours, truncated single-walled carbon nanotub...

Embodiment 3

[0045] Example 3, the multi-walled carbon nanotubes (MWCNTs) prepared by chemical vapor deposition method are used as the initial raw material, and after being shortened by acidification, chitosan or sodium alginate and folic acid are functionalized by non-covalent physical coating to the surface of multi-walled carbon nanotubes, and adopt doxorubicin (DOX) as a model drug to obtain folic acid-targeted chitosan or sodium alginate-modified multi-walled carbon nanotubes doxorubicin-targeted drug carrier, the specific steps are as follows :

[0046] Step (a): In 300 mL of 98% H with a volume ratio of 3:1 2 SO 4 and 65% HNO 3 Add 500 mg of multi-walled carbon nanotube raw material to the mixed acid, ultrasonicate for 24 hours in an ice-water bath at 0°C, filter with polytetrafluoroethylene microporous membrane with a pore size of Φ0.22 μm, and wash repeatedly with a large amount of deionized water until neutral, 50 After vacuum drying at ℃ for 24 hours, truncated multi-walled c...

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Abstract

The invention relates to a method for preparing a chitosan or sodium alginate-modified carbon nanotube-targeted slow release carrier in the technical field of nano materials, which comprises the following steps: preparing cut carbon nanotubes; preparing modified carbon nanotubes; preparing a modified carbon nanotube-targeted slow release carrier and adding aqueous solution of an anthracycline anticancer medicament; and subjecting the solution to supersonic treatment, stirring treatment and suction filtration, washing the product of the suction filtration, drying the product at room temperature under vacuum to obtain the chitosan or sodium alginate-modified carbon nanotube-targeted slow release carrier carrying the medicament. The method can realize an adriamycin carrying ratio of between 151 and 161 percent according to measurement.

Description

technical field [0001] The invention relates to a preparation method in the technical field of nano-medicines, in particular to a preparation method of a chitosan or sodium alginate modified carbon nanotube targeted slow-release carrier. Background technique [0002] Carbon Nanotube (CNT for short) is a new type of carbon structure discovered in recent years (S. Tijima, Nature 1991, 354, 56), which is a seamless graphene sheet formed by carbon atoms. Hollow carbon tubes, capped by half fullerene molecules at both ends, are one-dimensional quantum materials with highly delocalized π-electron conjugated systems. Carbon nanotubes are divided into single-wall nanotubes (Single-wall Nanotube, SWCNT) and multi-wall carbon nanotubes (Multi-wall Nanotube, MWCNT). Its preparation methods mainly include catalytic pyrolysis, arc discharge, template method, chemical vapor deposition method and so on. Since the advent of carbon nanotubes, with their unique electronic and mechanical pro...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/36A61K47/04A61K45/00A61P35/00A61K47/52A61K47/61
Inventor 张晓科孟令杰路庆华林高锋
Owner SHANGHAI JIAO TONG UNIV
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