Method for purifying pseudomonas acid A

A technology of pseudomonas acid and desorption liquid, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve the difficulty of industrial scale, the complicated operation of liquid-liquid extraction method, and a large amount of organic solvents, etc. problem, to achieve the effect of economical industrial scale production
CN101591333BInactive Publication Date: 2012-01-04SHANDONG JIANWEI BIOENG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG JIANWEI BIOENG
Publication Date
2012-01-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for purifying a pseudomonas acid A, which comprises the following steps: 1) absorption: absorbing solution containing the pseudomonas acid A with resin; 2) desorption: desorbing the pseudomonas acid A from the resin in the step 1) by using a solvent to obtain a desorption solution containing the pseudomonas acid A; and 3) processing the desorption solution containing the pseudomonas acid A obtained by the step 2) to obtain the pseudomonas acid A. The recovery rate and purity of pseudomonas acid A purified by the method provided by the invention reach 79 percent and over 98 percent respectively. The method for purifying the pseudomonas acid A (mupirocin) by using resin of the invention has obvious advantages in aspects of ecology, environmental protection, economy and industrial large-scale production.
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Description

technical field

[0001] The invention relates to a method for purifying pseudomonic acid A. Background technique

[0002] Fermentation with Pseudomonas strains can synthesize multiple chemical components of antibiotics mainly composed of Pseudomonic Acid A. Except for Pseudomonic Acid A, other components are named with letters B-D [E.B.Chain, G.Mellows, J. Chem. Soc. Perkin Trans I. 318 (1977); J.P. Clayton et al., Tetrahedron Lett., 21, 881 (1980); P. J. O. Hanlon, N. H. Rogers, J. Chem. Perkin Trans I. 2665 (1983)]. Pseudomonic acid A is an aminoacyltransaminase inhibitor antibiotic, which can specifically bind to the isoleucine transfer RNA synthetase of bacteria, thereby inhibiting the synthesis of isoleucine-containing proteins in bacteria; Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and metmoxicillin-resistant bacteria, have high medical value and have been clinically used for a long time. Pirocin ointme...

Claims

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