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Flow sensing for determination of assay results

A technology for testing results and flow velocity, applied in fluid velocity measurement, velocity/acceleration/impact measurement, material analysis by observing the influence of chemical indicators, etc., which can solve inaccurate problems

Inactive Publication Date: 2011-11-09
INVERNESS SWITZERLAND GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been found that these different types of fluid flow characteristics can lead to inaccurate results

Method used

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  • Flow sensing for determination of assay results
  • Flow sensing for determination of assay results
  • Flow sensing for determination of assay results

Examples

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example 1

[0056] An embodiment of an assay result readout device according to the present invention is shown in figure 1 .

[0057] The readout device is approximately 12 cm long by 2 cm wide and is generally finger or cigar shaped. In a preferred embodiment, the housing is no longer than about 12 cm, about 2.5 cm wide, and 2.2 cm high. However, any convenient form may be used, such as a credit card form reader. The device comprises a housing 2, made of a light-impermeable synthetic plastic material (such as polycarbonate, ABS, polystyrene, high-density polyethylene, or polypropylene or polystyrene containing a suitable light blocking pigment). At one end of the reading device there is a narrow slot or hole 4 through which a test strip (not shown) can be inserted into the reader.

[0058] On its upper surface, the reader includes two oval apertures. A screen of a liquid crystal display 6 is installed in a small hole, and displays, for example, test results to the user in a qualitati...

example 2

[0088]A set of optics is used to determine the signal and flow rate. The maximum and minimum flow rates were set to 5 and 40 s, respectively. So any sample after more than 40s is discarded as too slow (probably due to undersampling), and any sample faster than 5s is discarded as too fast. Flow rates can be affected by a number of factors, including porosity, distance between control and test zones, and any chemical properties within the porous strip that may alter flow rates.

[0089] Timing is determined and set to zero when fluid reaches the test line. The timer is then set and measures the time it takes for the liquid to reach the control line. As a further control check, the device monitors the passage of liquid through the reference zone. As a further control feature, the device also monitors that the fluid passes through the test, reference and control zones sequentially before the flow rate measurement is considered reliable, even if it meets the flow rate range of 5...

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Abstract

The present invention relates to flow sensing for determination of assay results. An assay result reading device for reading the result of an assay performed using a liquid transport carrier may include at least one light source capable of emitting light incident upon at least one of two or more spatially separated zones of the carrier, a photodetector so positioned as to be capable of detecting light emanating from each of the two said zones and generating signals representing the presence or absence of a fluid sample in the respective zone, and a computation circuit. The computation circuitmay be responsive to the signals to calculate a flow rate for a fluid flowing along the carrier, compare the calculated flow rate to upper and lower limits, and reject the assay result if the calculated flow rate is outside the upper and lower limits.

Description

[0001] This application is a divisional application of Chinese invention patent application 200410045275.3 (application date: June 4, 2004). technical field [0002] The disclosed subject matter relates to devices for reading measurements of a subject being assayed. In particular, it relates to electronic readers for use with assay strips using optical measurement methods. Background technique [0003] A variety of analytical devices are currently commercially available for testing assays for home use. Unipath is at A lateral flow immunoassay device suitable for measuring the pregnancy hormone human chorion (hCG) is sold under the trade name EP291194. [0004] In particular, EP291194 discloses an immunoassay device comprising: a porous carrier containing a microparticle-labeled specific binding reagent for an analyte which is free to move in a wet state; and a An unlabeled specific binding reagent for the same analyte immobilized in a detection zone or test zone downstre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01P5/18G01N21/17G01N21/27G01N21/25G01N21/78G01N21/86
CPCG01N21/274G01N21/251G01N2021/8488G01N21/8483G01N2201/06106G01N2021/8494G01N21/78G01N2201/062
Inventor S·P·沙罗克
Owner INVERNESS SWITZERLAND GMBH