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Contraceptive vagina gel with function of killing microorganism

A vaginal gel and antimicrobial technology, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and drug combinations, etc. It can solve the problems of many ingredients in the formula, complicated preparation methods, and large vaginal irritation.

Inactive Publication Date: 2009-12-23
BIRTH CONTROL INST TIANJING CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems in the prior art that the medicine has great irritation to the vagina, many formula materials, and complicated preparation methods, the present invention provides a contraceptive medicine that can reduce unwanted pregnancy and reduce the incidence of HIV and other sexually transmitted diseases, which can be used independently by women. Contraceptive vaginal gel with high efficiency, good effect in preventing reproductive tract infection, simple process, easy to use, and small vaginal irritation with microbicidal effect

Method used

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  • Contraceptive vagina gel with function of killing microorganism
  • Contraceptive vagina gel with function of killing microorganism
  • Contraceptive vagina gel with function of killing microorganism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The preparation method of embodiment 1 gel of the present invention

[0084] raw material:

[0085] Hydroxypropylmethylcellulose, propylene glycol, glycerin, and potassium sorbate are all commercially available. Polycresol: provided by Jinan Qihe Synthetic Fine Chemical Co., Ltd., batch number: 050802; octoxynol: Sigma-Aldrich (Shanghai) Trading Company (ICEPL CA 630), batch number: 075K0071; purified water: self-made.

[0086] formula

[0087] Hydroxypropyl Methyl Cellulose 3.0g

[0088] Propylene glycol 10g

[0089] Glycerin 10g

[0090] Polycresol 1.8g

[0091] Octoxynol 2.0g

[0092] Potassium sorbate 0.15g

[0093] Appropriate amount of purified water

[0094] Total 100g

[0095] Preparation:

[0096] Propylene glycol and glycerin are weighed according to the formula, and after mixing evenly, hydroxypropyl methylcellulose is added while stirring to disperse the mixed solution evenly, and then octoxynol is added, and stirred evenly. Potassium sorbate and ...

Embodiment 2

[0241] raw material

[0242] Carboxymethyl cellulose, propylene glycol, glycerin, and potassium sorbate are all commercially available; polycresol sulfonaldehyde: provided by Jinan Qihe Synthetic Fine Chemical Co., Ltd., batch number: 050802; octoxynol: Sigma-Aldrich: (Shanghai) Available from Trading Company (ICEPL CA 630), lot number: 075K0071. Purified water: homemade.

[0243] formula

[0244] Carboxymethylcellulose 3.0g

[0245] Propylene glycol 1.0g

[0246] Glycerin 1.0g

[0247] Polycresol 1.8g

[0248] Octoxynol 2.0g

[0249] Sodium Benzoate 0.15g

[0250] Appropriate amount of purified water

[0251] Total 100g

[0252] Preparation method is the same as embodiment 1

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PUM

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Abstract

The invention relates to contraceptive vagina gel with the function of killing microorganisms, and belongs to a contraceptive. The gel consists of spermatocide, bactericide, matrix, humectant, preservative and water and is prepared by the following steps: adding the matrix into the humectant, adding under stirring to evenly disperse the mixture, adding the spermatocide, and evenly stirring the mixture; and adding the bactericide and the preservative into purified water of prepared quantity, stirring the mixture into even solution, mixing the two solutions together, stirring the mixture completely and evenly, and defoaming the mixture to obtain the gel. The gel is a compound preparation, has functions of contraception and broad spectrum microorganism resistance, uses hydroxypropyl methyl cellulose as the gel, ensures that the medicament has excellent biocompatibility with vagina mucosa, and has the advantages of strong adhesive force, long adhesive time, difficult drain, long effective time, low toxicity, small irritation, and the like.

Description

technical field [0001] The invention relates to a contraceptive appliance and a preparation method, in particular to a contraceptive vaginal gel with antimicrobial effect. Background technique [0002] The epidemic of AIDS in my country has entered a period of rapid growth. According to the report of the Ministry of Health of my country in 2002, there were nearly 1 million HIV-infected people nationwide. Among the HIV-infected women, the vast majority are women of childbearing age, who are infected through sexual behavior, and they can also cause mother-to-child transmission after being infected. In order to reduce unwanted pregnancy and prevent the transmission of sexually transmitted diseases such as AIDS, as a strategy to prevent AIDS, international organizations such as the World Health Organization and UNAIDS have prioritized the development of microbicidal contraceptives actively used by women. In order to maintain women's reproductive health and protect women's legit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/34A61K47/36A61K47/38A61K31/765A61K31/4164A61K31/496A61K31/795A61P15/18A61P31/02A61K31/08A61K47/10
Inventor 沈丽琳候庆昌邵长风陈坚张颖刘苗苗张繁王江贺其刚李伟
Owner BIRTH CONTROL INST TIANJING CITY
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