Anti-adhesion gel containing polyhydroxyalkanoate
A technology of hydroxybutyric acid and hydroxycaproic acid, which is used in medical preparations containing active ingredients, surgical drugs, organic active ingredients, etc. manipulation, effect of excellent histocompatibility
Inactive Publication Date: 2010-01-06
SHANTOU UNIV
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Problems solved by technology
(Saravelos HG, 1996; Yeo, Y. and Kohane, D.S, 2008) The purity of chitosan is not high enough, it is easy to gel when in contact with body fluids, and the anti-adhesion effect is not ideal
Sodium hyaluronate degrades and absorbs too quickly, and the anti-adhesion effect is not ideal (Wiseman D, 1994; Zhu Xiaoming et al., 2002)
At present, the biodegradable synthetic material PLA, which is widely used in tissue engineering materials, has many advantages and was once considered a promising material. However, the chemically synthesized PLA has low molecular weight, poor mechanical strength, and too fast degradation rate. In addition, as a synthetic polymer material, it lacks cell recognition signals (Chen & Wu, 2005). In addition, due to the characteristics of the polylactic acid material itself, the membrane is brittle and hard, and the tingling sensation to the tissue is also limited. Its wide application in medical tissue engineering (Gao et al, 2006)
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0074] PHBHHx with a molecular weight of 310,000 HHx and a content of 12 mol%, 12 times the weight of N-methylpyrrolidone, can be obtained by adding N-methylpyrrolidone to PHBHHx and stirring.
Embodiment 2
[0076] PHBHHx with a molecular weight of 310,000 HHx and a content of 12 mol%, 12 times the weight of N,N-dimethylacetamide, can be obtained by adding N,N-dimethylacetamide to PHBHHx and stirring.
Embodiment 3
[0078] PHBHHx with a molecular weight of 310,000 HHx and a content of 12 mol% and 12 times the weight of pyrrolidone can be obtained by adding pyrrolidone to PHBHHx and stirring.
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The invention relates to an anti-adhesion gel containing polyhydroxyalkanoate and specifically the invention provides an anti-adhesion gel containing hydrophilic organic solvent and polyhydroxyalkanoate. The invention also provides an application of polyhydroxyalkanoate for preparing the medicament used for preventing postoperative adhesions.
Description
technical field [0001] The present invention relates to anti-adhesion gels comprising polyhydroxyalkanoates and hydrophilic organic solvents. The present invention also relates to the use of polyhydroxyalkanoate in the preparation of a medicament for preventing postoperative adhesions. Background technique [0002] The formation of tissue adhesions is a general response of the body to tissue trauma such as the peritoneum. Due to tissue trauma, connective tissue fiber bands are combined with adjacent tissues or organs to form abnormal structures. Tissue adhesion is a common pathological reaction (collectively called postoperative tissue adhesion in medicine), most of which occur after surgery (Menzies D, 1992; Dizerega GS, 1994; Holtz G, 1984; Ellis H, 1982). [0003] Adhesions formed between the wound and the omentum, most cases will involve the intestinal tract and other surrounding organs, causing serious complications such as intestinal obstruction, abdominal pain, femal...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K31/765A61P41/00
Inventor 陈国强代忠伟
Owner SHANTOU UNIV
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