Preparation method for radioactivity TiNi alloy bracket without fringe effect

An edge effect and radioactive technology, applied in radiation therapy, stents, medical science, etc., can solve the problems of uneven dose, high restenosis rate at the edge of the stent, weak ray penetration, etc., to achieve suppression of edge effects, excellent super The effect of elasticity and good corrosion resistance

Inactive Publication Date: 2010-01-20
HARBIN INST OF TECH
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AI Technical Summary

Problems solved by technology

[0004] The purpose of the invention is to solve pure 32 The problem of high restenosis rate at the edge of the stent caused by weak P-ray penetration and uneven dose around the stent provides a method for preparing a non-edge effect radioactive TiNi alloy stent

Method used

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  • Preparation method for radioactivity TiNi alloy bracket without fringe effect
  • Preparation method for radioactivity TiNi alloy bracket without fringe effect
  • Preparation method for radioactivity TiNi alloy bracket without fringe effect

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Experimental program
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specific Embodiment approach 1

[0008] Embodiment 1: The method for preparing the radioactive TiNi alloy stent without edge effect in this embodiment is realized by the following steps: 1. Take 50.6% Ni, 0.032% C, 0.003% H, 0.045% O, 0.040% by atomic percentage % Fe and the remainder of Ti are mixed, and then melted in a water-cooled copper crucible vacuum induction melting furnace to obtain ingots; 2. Clean the surface of the ingot, and then homogenize it at a temperature of 750-850°C for 8-24 hours. Then, the billet is forged at a temperature of 800°C, and then hot-rolled at a temperature of 650-800°C, and then turned into a bar with a diameter of 1.5cm at a temperature of 650-800°C. Then, under the condition of temperature of 700°C and pass deformation of 10%, it is hot-drawn into a hot-drawn wire with a diameter of 2mm, then sand blasted, and then cold-drawn to a diameter of 0.24mm under the condition of a pass deformation of 10%. Cold-drawn wire, and finally cold-drawn into a cold-drawn wire with a diam...

specific Embodiment approach 2

[0011] Embodiment 2: This embodiment differs from Embodiment 1 in that in Step 2, the homogenization treatment is performed at a temperature of 800° C. for 12 hours. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0012] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the temperature of the hot rolling treatment in step 2 is 700°C. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

A preparation method for radioactivity TiNi alloy bracket without fringe effect relates to a preparation method for a radioactivity bracket. The preparation method solves the problem of high restenosis rate of the edge of the bracket caused by weak penetrating power of a pure <32>P ray and uniform dosage around the bracket. The method comprises the following steps of: 1. preparing a cast ingot, 2. preparing cold-drawn wires; 3 twisting cold-drawn wires into a bracket, heat processing in vacuum, chemical polishing, ultrasonic washing and drying; 4. putting the dried bracket into a plasma-based injection system for slow neutrons irradiation; 5. annealing the irritated bracket and then cooling the irritated bracket, thus obtaining the radioactivity TiNi alloy bracket. The radioactivity TiNi alloy bracket obtained by the invention both preserves the excellent superelasticity, good corrosion resistance and biomedical science performances of the alloy, also can obtain mixed rays dominated by <32> P, and improves the uniformity of the dosage distribution of the rays around the bracket and is beneficial to inhibiting the fringe effect.

Description

technical field [0001] The invention relates to a preparation method of a radioactive stent. Background technique [0002] Vascular stents have been widely used in the prevention and treatment of clinical symptoms such as early elastic recoil of vessel wall, vessel wall dissection and late vessel restenosis after percutaneous transluminal angioplasty (PTCA), and achieved good results. Inevitably causing vascular injury during surgery, stimulating excessive proliferation of tissues, especially the proliferation of smooth muscle cells (SMCs) and extracellular matrix (ECM), will lead to restenosis (RS) of blood vessels at the stent. Clinical statistics show that about 20% to 30% of the medical records of stent treatment have restenosis within three months to one year after operation, which has become the main obstacle limiting stent treatment. Once it occurs, there is no effective remedy. [0003] The radioactive stent organically combines the mechanical support function of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61N5/00A61L27/06
Inventor 高智勇赵兴科蔡伟隋解和吴冶
Owner HARBIN INST OF TECH
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