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Temperature-sensitive hydrogel containing adamantyl and preparation method and application thereof

A temperature-sensitive hydrogel and adamantyl technology, applied in the field of temperature-sensitive hydrogel and its preparation, can solve the problems of not being able to respond quickly at the same time, and achieve rapid deswellability, high mechanical strength, and response rate fast effect

Inactive Publication Date: 2010-01-27
GUANGZHOU INST OF GEOCHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The primary purpose of the present invention is to overcome the inadequacies of thermosensitive hydrogels that cannot simultaneously have fast response, good mechanical strength and volume phase transition temperature in the prior art, and provide a kind of mechanical strength and temperature response performance Thermosensitive adamantyl-containing hydrogels with easy regulation, high mechanical strength and fast response

Method used

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  • Temperature-sensitive hydrogel containing adamantyl and preparation method and application thereof
  • Temperature-sensitive hydrogel containing adamantyl and preparation method and application thereof
  • Temperature-sensitive hydrogel containing adamantyl and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh the hydrophobic monomer adamantyl methacrylate (AdMA, the structure is as R in the general formula 0 =CH 3 , R 1 = H, R 2 = H, R 3=H) 0.01g in a small reaction vial, then add 1g of N-isopropylacrylamide (NIPAM) and 30mg of N,N'-methylenebisacrylamide, then add 7ml of 1,4-dioxane , shake until the solids are completely dissolved, add 12.5 mg of initiator azobisisobutyronitrile, and seal the tube after 4 cycles of vacuum pumping and nitrogen filling, and put the reaction bottle in an oil bath at 75°C for 10 h. The obtained colorless and transparent gel was soaked in distilled water for 5 days, first soaked in distilled water at 20°C for 24 hours, then placed in distilled water at 40°C to allow it to shrink naturally, and then changed the water, after four cycles, keep soaking in distilled water at room temperature , to obtain adamantyl-containing temperature-sensitive hydrogel AdMA1.

Embodiment 2

[0042] The preparation of the adamantyl-containing temperature-sensitive copolymer hydrogel AdMA3, only the feed ratio of the hydrophobic monomer AdMA and NIPAM is 3%, and the other raw material feed ratios and reaction steps are the same as in Example 1, and the adamantyl-containing temperature-sensitive copolymer hydrogel is obtained. Sensitive hydrogel AdMA3.

Embodiment 3

[0044] The preparation of the temperature-sensitive copolymer hydrogel AdMA5 containing adamantyl, only the feed ratio of hydrophobic monomer AdMA and NIPAM is 5%, and the feed ratio and reaction steps of other raw materials are the same as in Example 1, and the temperature-sensitive copolymer hydrogel containing adamantyl is obtained. Sensitive hydrogel AdMA5.

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Abstract

The invention discloses a temperature-sensitive hydrogel containing adamantyl and a preparation method and an application thereof. The preparation method comprises the following steps: adopting organic solvent to dissolve crosslinking agent and monomer which is composed with N-isopropylacrylamide and at least one hydrophobic monomer with adamantyl, then adding initiator to react at 55-85 DEG C for 6-24h under the protection of inert gas, then treating by using distilled water and obtaining the temperature-sensitive hydrogel containing adamantly. The temperature-sensitive hydrogel containing adamantly has excellent properties such as higher mechanical strength and fast deswelling dynamics and easily controllable mechanical strength and temperature response performance, and overcomes the problem that the temperature-sensitive hydrogel provided by the prior art does not have good comprehensive performance. The temperature-sensitive hydrogel containing adamantly can be widely used in fields such as drug delivery, material separation, biosensors, switching valves, reaction control, biomedical material and the like.

Description

technical field [0001] The invention relates to a thermosensitive hydrogel, in particular to an adamantyl-containing thermosensitive hydrogel and a preparation method and application thereof. Background technique [0002] Poly(N-isopropylacrylamide) (PNIPAM) is a typical temperature-sensitive hydrogel. It has a lowest critical solution temperature or volume phase transition temperature (LCST) in the aqueous solution. Near this LCST, the PNIPAM hydrogel can sense small changes in the external temperature and suddenly absorb or dehydrate so that its own volume undergoes dramatic changes. Shrink or expand. This change in volume is discontinuous. Utilizing this special temperature stimulus response characteristic, PNIPAM hydrogel has been widely used in many aspects, such as separation and purification of substances in the chemical industry, control of chemical reactions; control of drugs in biomedicine Release and immobilization of enzymes; used in the machinery industry to ...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F220/16C08F2/06A61K47/32
Inventor 吕满庚朱东雨郭建维梁利岩黄艳玲
Owner GUANGZHOU INST OF GEOCHEMISTRY - CHINESE ACAD OF SCI
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