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Magnetic hollow compound micro-structure immobilized enzyme and method for preparing same

An immobilized enzyme, hollow technology, applied in the direction of immobilization on or in the inorganic carrier, on or in the biological cell, fixed on/in the organic carrier, etc., can solve the problem that the structure is easily affected by the external environment , Difficulty in separation and recovery, difficulty in continuous utilization, etc., to achieve the effect of simple immobilization technology, wide range of sources, and rich surface functional groups

Inactive Publication Date: 2011-06-01
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional free enzymes have some disadvantages, such as their structure is easily affected by the external environment and inactivation occurs; it is difficult to separate and recover after use, and it is difficult to achieve continuous utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1. Magnetic Hollow Composite Microstructure Immobilized Enzyme

[0020] a) Weigh 5 g of ellipsoidal beer yeast (Saccharomyces cerevisiae), disperse it in 100 ml of deionized water to make a yeast suspension, then transfer the yeast suspension to a reaction kettle, place it in an incubator and heat it at 180°C for 18 hours, and react After the end, the precipitate was collected, washed with deionized water, and then dried at 20° C. for 24 h. After drying, hollow polysaccharide microspheres are obtained. The hollow polysaccharide microspheres were observed by scanning electron microscope, and the hollow polysaccharide microspheres were characterized by infrared.

[0021] The structure of the hollow polysaccharide microspheres under the scanning electron microscope is a hollow microsphere with a diameter of 2-3 microns. The infrared characterization results show that the surface of the hollow polysaccharide microspheres contains -OH, -C=O and other functional grou...

Embodiment 2

[0027] Example 2, Magnetic Hollow Composite Microstructure Immobilized Enzyme

[0028] a) Weigh 5 g of ellipsoidal beer yeast (Saccharomyces cerevisiae), disperse it in 100 ml of deionized water to make a yeast suspension, and then add dilute hydrochloric acid to the yeast suspension to make the final concentration 0.1mol / L. The solution was transferred to a reaction kettle, placed in a thermostat and heated at 150°C for 24h. After the reaction, the precipitate was collected, washed with deionized water, and then dried at 20°C for 24h. After drying, hollow polysaccharide microspheres are obtained. The hollow polysaccharide microspheres were observed by scanning electron microscopy. The hollow polysaccharide microsphere is jar-shaped with a diameter of 2-3 microns.

[0029] b) Weigh 3.0 g of jar-shaped hollow polysaccharide microspheres in a), disperse them in 50 ml of deionized water, add ferric chloride to keep its concentration at 0.01mol / L, then add manganese chloride to ...

Embodiment 3

[0034] Example 3, Magnetic Hollow Composite Microstructure Immobilized Enzyme

[0035] a) Weigh 5 g of ellipsoidal beer yeast (Saccharomyces cerevisiae), disperse it in 100 ml of deionized water to make a yeast suspension, then add sodium chloride to the yeast suspension to make the final concentration 0.01mol / L, and mix the above The suspension was transferred to a reaction kettle, placed in a thermostat and heated at 150° C. for 24 hours. After the reaction, the precipitate was collected, washed with deionized water, and then dried at 20° C. for 24 hours. After drying, the hollow polysaccharide microspheres are obtained, and the hollow polysaccharide microspheres are observed with a scanning electron microscope, and the hollow polysaccharide microspheres are spherical with a diameter of 2-3 microns.

[0036]b) Weigh 3.0 g of spherical hollow polysaccharide microspheres in a), disperse them in 50 ml of deionized water, add ferric chloride to keep its concentration at 0.01mol / ...

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Abstract

The invention discloses a magnetic hollow compound micro-structure immobilized enzyme and a method for preparing the same. The immobilized enzyme comprises enzyme and a carrier for immobilizing the enzyme, wherein the carrier is a magnetic hollow polysaccharide microsphere consisting of a core and a shell; the shell covers the outer surface of the core and is formed by ferrites; the core is a hollow polysaccharide microsphere; and the method for preparing the hollow polysaccharide microsphere comprises a step of carbonizing yeast in liquid to obtain the hollow polysaccharide microsphere undera condition of constant temperature which is any constant temperature between 150 and 240 DEG C. The invention also discloses a method for preparing the immobilized enzyme. The magnetic hollow compound micro-structure immobilized enzyme has high pheron-carrying quantity, high enzymatic activity and strong enzymatic stability and operational stability and can be easily recovered under a condition of external magnetic fields.

Description

technical field [0001] The invention relates to a magnetic hollow composite microstructure immobilized enzyme and a preparation method thereof. Background technique [0002] Enzyme is a biocatalyst with important application value in many fields. It has the advantages of high catalytic rate, strong reaction specificity, mild catalytic conditions, low energy consumption and no pollution. Traditional free enzymes have some disadvantages, such as their structure is easily affected by the external environment and inactivation occurs; it is difficult to separate and recover after use, and it is difficult to realize continuous utilization. Enzyme immobilization technology is one of the effective measures to solve these problems. The immobilized enzyme not only retains the catalytic properties of the enzyme, can improve the storage stability and operation stability of the enzyme, but also can realize the recovery and continuous utilization of the enzyme, thereby reducing the input...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N11/16C12N11/14C12N11/04
Inventor 杨森周克斌倪德志王雷
Owner CHINA AGRI UNIV