Method for preparing traditional Chinese medicine preparation containing Sambucus chinensis Lindl. extracts

Abstract

The invention provides a method for preparing a traditional Chinese medicine preparation containing Sambucus chinensis Lindl. extracts. The preparation comprises the Sambucus chinensis Lindl. extracts, micro silica gel and water in parts by weight. The preparation method comprises the following steps: grinding the Sambucus chinensis Lindl. extracts into fine powder and sieving the fine powder forstandby use; grinding the micro silica gel into fine powder, sieving the fine powder, adding water and mixing the fine powder with the fine powder of the extracts to prepare granules; directly tabletting and coating the granules, thus obtaining the preparation. The dose of the medicine prepared by the invention is greatly reduced and the compliance of the patients is improved; therefore, the preparation is favorable for clinical application.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine preparation containing an extract of Lu Ying. Background technique [0002] Luying is the whole herb of Sambucus Chinensis Lindl., also known as elderberry, capsule, and Zoumafeng, etc. It is a commonly used herbal medicine in my country. It is mainly used for bruises, rheumatism, nephritis edema, beriberi edema, pneumonia, icteric hepatitis and other diseases. At the end of the 1970s, Luying decoction, syrup, and Chongji were used to treat 1,115 cases of acute viral hepatitis in Yichun, Jiangxi. The cure rate was 83.95%, and the effective rate was 98.2%. Edited by the Institute of Medical Sciences, Yichun District, Jiangxi Province, Medical Research Materials, 1978, 13-14]. Luying mainly contains ursolic acid, oleanolic acid, β-sitosterol, stigmasterol and other ingredients, among which u...

AI Technical Summary

Problems solved by technology

Due to the large amount of thick paste, a large amount of excipients need to be added when granulating, resulting in excessive dosage, 8 tablets each time, poor patient compliance, which seriously restricts its clinical application

Drying the thick paste into a dry paste, and then granulating it by the commonly used wet granulation method cannot effectively solve this problem

Due to the large amount of dry paste and high viscosity, it is necessary to use high-concentration ethanol for granulation. Due to the fast alcohol volatilization, there are many granules, and the granule yield is low; moreover, the prepared granules are loose, easy to produce fine powder, and the granules are uneven, which affects tableting. quality

In addition, the cost of alcohol is high, and there are certain safety hazards, so it needs to be operated in an explosion-proof room

At present, the commonly used granulation method is dry granulation, but dry granulation requires high equipment, complicated procedures, and difficult control of moisture and particle size.

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