Praziquantel injection, preparation method and application thereof
A praziquantel and injection technology, applied in the field of praziquantel medicines, can solve the problems of no killing effect on schistosomiasis, limiting the effect of treating schistosomiasis, etc., and achieves favorable drug absorption, early effective prevention and control of schistosomiasis, and strong killing effect. Effect
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[0028] The preparation method of praziquantel injection of the present invention comprises the following steps:
[0029] Heat an appropriate amount of 206 adjuvant, aqueous solution or purified water to 28°C-32°C respectively;
[0030] Mix the preheated 206 adjuvant and praziquantel, add preheated aqueous solution or purified water and mix evenly until the emulsion-like praziquantel injection is obtained.
[0031] Preferably, the mixing step is realized by pushing the syringe back and forth or stirring by the stirring device, which is conducive to uniform mixing.
[0032] Preferably, the obtained emulsion-like praziquantel injection is stored at 4° C. to 12° C., so that the effective time of the praziquantel injection can be significantly prolonged.
Embodiment 1
[0033] The preparation of embodiment 1 praziquantel injection
[0034] 1. Laboratory scale:
[0035] Heat the 206 adjuvant and PBS (PH8.0) to 30°C±2°C respectively;
[0036] Add praziquantel drug to 206 adjuvant; add PBS (206 adjuvant / (praziquantel+PBS)=50 / 50 weight ratio);
[0037] Mix using a 10-50ml syringe with a needle and no rubber stopper; push back and forth 10-20 times.
[0038] The prepared emulsion was stored at 4°C to 12°C.
[0039] 2. Using a homogenizer (150ml emulsion configuration as an example):
[0040] Heat 87ml of 206 adjuvant and PBS (pH8.0) to 30°C±2°C respectively;
[0041] Weigh 7.5-60g of praziquantel, place it in a sterile beaker, and add 87ml of 206 adjuvant;
[0042] Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing praziquantel and 206 adjuvant;
[0043] Start stirring at low speed (200-300 rpm) and gradually add PBS, accelerate to 2000 rpm and keep for 10 minutes;
[0044] Stirring was stopped and the pr...
Embodiment 2
[0053] (1) Measure 54ml of 206 adjuvant; prepare 41.2ml of sterilized PBS (PH8.0); heat the above solvent to 30°C±2°C;
[0054] (2) Weigh 4.8g of praziquantel, pour it into a sterile beaker, and preheat to 30°C±2°C;
[0055] (3) Add 54ml of preheated 206 adjuvant into the beaker;
[0056] (4) Place the rotor of the FJ-200 high-speed dispersing homogenizer in a beaker containing praziquantel and 206 adjuvants;
[0057] (5) Start stirring at low speed (200-300 rpm) and gradually add 41.2ml of preheated PBS, the flow rate of PBS is 5-10 liters / min;
[0058] (6) Accelerate to 2000 rpm and keep it for 10 minutes;
[0059] (7) Stop stirring to prepare the praziquantel injection containing 5% (weight percentage) praziquantel, wherein the weight percentage of 206 adjuvant is 50%, and the volume percentage is 54%; then the prepared emulsion is placed at low temperature (4°C ~ 12°C).
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