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Preparation method of macroporous absorption resin

A pore adsorption and resin technology, applied in the field of macroporous adsorption resin preparation, can solve the problems of high dispersant price, mixing of drugs, secondary pollution, etc.

Inactive Publication Date: 2010-04-14
崔建
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main emissions of this preparation method are gelatin, toluene and liquid wax, acetone, and the recovery rate of the porogen is very low (only about 15%), so that the pollution is relatively large; the price of the dispersant is high, and the consumption is large, so that the production cost higher
The macroporous adsorption resin prepared by this preparation method generally has a specific surface area of ​​about 500m2 / g, which is subject to certain restrictions in application, and when some resins are used in the extraction and separation of drugs, the crosslinking agent or porogen in these resins Agents and other organic residues will be mixed into the drug, causing secondary pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] A kind of preparation method of macroporous adsorption resin, comprises the steps:

[0079] (1) 90g divinylbenzene (for skeleton raw material), 117g isooctane (for porogen), 0.6g benzoyl peroxide (for initiator), 5.8g polyethylene Alcohol (being a dispersant) was added into 650g deionized water, fully mixed and stirred (the stirring speed in the polymerization reaction process was 30 rpm), and the temperature of the mixed solution was successively raised in four stages to carry out the suspension polymerization reaction, so that the mixed solution gradually Solidify into 20-60 mesh milky white spherical particles. The polymerization temperature and polymerization reaction time are as follows: first raise the temperature of the mixture to 65°C within 45 minutes, maintain it for 2 hours, and then raise the temperature of the mixture to 75°C within 15 minutes , maintained for 6 hours, then raised the temperature of the mixed solution to 85°C within 15 minutes, maintained f...

Embodiment 2

[0083] A kind of preparation method of macroporous adsorption resin, comprises the steps:

[0084] (1) 105g divinylbenzene (for skeleton raw material), 136g n-pentane (for porogen), 0.7g benzoyl peroxide (for initiator), 6.8g polyethylene Alcohol (being a dispersant) was added into 750g deionized water, fully mixed and stirred (the stirring speed in the polymerization reaction process was 33 rpm), and the temperature of the mixed solution was successively raised in four stages to carry out the suspension polymerization reaction, so that the mixed solution gradually Solidify into milky white spherical particles of 20-60 mesh. The polymerization temperature and polymerization reaction time are: first raise the temperature of the mixture to 70°C within 52 minutes, maintain it for 1.5 hours, and then raise the temperature of the mixture to 80°C within 15 minutes , maintained for 5 hours, then raised the temperature of the mixed solution to 87°C within 15 minutes, maintained for 5 ...

Embodiment 3

[0088] A kind of preparation method of macroporous adsorption resin, comprises the steps:

[0089](1) 120g divinylbenzene (for skeleton raw material), 156g isooctane (for porogen), 0.8g benzoyl peroxide (for initiator), 7.7g polyethylene Alcohol (being a dispersant) was added into 850g deionized water, fully mixed and stirred (the stirring speed in the polymerization reaction process was 35 rpm), and the temperature of the mixed solution was successively raised in four stages to carry out the suspension polymerization reaction, so that the mixed solution gradually Solidify into 20-60 mesh milky white spherical particles. The polymerization temperature and polymerization reaction time are as follows: first raise the temperature of the mixed solution to 75°C within 60 minutes, maintain it for 1 hour, and then raise the temperature of the mixed solution to 85°C within 15 minutes , maintained for 4 hours, then raised the temperature of the mixed solution to 90°C within 15 minutes,...

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Abstract

The invention relates to a preparation method of macroporous absorption resin, which comprises the following steps of adding framework raw materials, a pore-forming agent, an initiating agent and a dispersing agent into deionized water, fully stirring and mixing; sequentially raising the temperature of a liquid mixture for suspension polymerization by four stages to gradually cure the liquid mixture to oyster white 20-60mu spherical particles, wherein the framework raw materials are divinylbenzene with the weight percentage concentration of 80 percent, the pore-forming agent is one of isooctane and n-pentane, the initializing agent is benzoyl peroxide, and the dispersing agent is polyvinyl alcohol; transferring the oyster white spherical particles into an elution column, introducing vapour with temperature of 130-150 DEG C as an eluting agent, eluting the pore-forming agent remained in the oyster white spherical particles; and sieving the obtained oyster white spherical particles to obtain the 20-60mu macroporous absorption resin with specific surface area more than 800m2 / g. The method has little pollution and low production cost; and the prepared macroporous absorption resin has better property.

Description

technical field [0001] The invention relates to a preparation method of a macroporous adsorption resin. Background technique [0002] The separation technology using macroporous adsorption resin is one of the new separation technologies after ion exchange resin developed in the late 1960s, and has been widely used in the fields of environmental protection, food and medicine. In recent years, the application in the field of pharmacy, especially in the extraction and separation of natural medicines, has received special attention, and now some adsorbent resins have been used in hemoperfusion to remove harmful substances in the blood. high. [0003] Macroporous adsorption resin is a kind of macromolecular adsorbent without exchange group. It is generally milky white spherical particles with stable physical and chemical properties, insoluble in acids, alkalis and organic solvents. Its adsorption is due to van der Waals' attraction or the result of hydrogen bonds, and it has th...

Claims

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Application Information

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IPC IPC(8): C08F112/36C08F2/20C08J9/14B01J20/30B01J20/26
Inventor 崔建
Owner 崔建
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