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Method for preparing cefaclor dispersible tablets by dry method direct tablet compressing and cefaclor dispersible tablets prepared by same

A technology of cefaclor and dispersible tablets, which is applied in the direction of medical formulations, organic active ingredients, and medical preparations of non-effective ingredients, etc., and can solve the problems of cefaclor dispersible tablets stability, many process steps, and large drug loss. , to achieve the effect of short cycle, simple equipment and small drug loss

Inactive Publication Date: 2010-05-26
ANHUI ANKE BIOTECHNOLOGY (GRP) CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the production of cefaclor dispersible tablets in my country adopts the process of wet granulation and tablet compression. After mixing the drug and auxiliary materials, adding a binder to make a soft material, and then granulating, drying, mixing, and then tableting. But its process step is more, and cycle is long, and medicine loss is bigger, because need the process of high temperature drying in this process, have influence on the stability of cefaclor dispersible tablet

Method used

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  • Method for preparing cefaclor dispersible tablets by dry method direct tablet compressing and cefaclor dispersible tablets prepared by same
  • Method for preparing cefaclor dispersible tablets by dry method direct tablet compressing and cefaclor dispersible tablets prepared by same
  • Method for preparing cefaclor dispersible tablets by dry method direct tablet compressing and cefaclor dispersible tablets prepared by same

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preparation example Construction

[0026] The preparation method of the present invention is to prepare cefaclor dispersible tablets by direct compression of dry powder. The so-called direct compression of dry powder is to mix the raw drug powder with the processed adjuvant without going through steps such as making soft materials, granulating, and drying. Directly carry out tabletting; In the present invention, at first cefaclor crude drug and auxiliary material are passed through 80 mesh sieves respectively, can screen out larger particle and crystal like this, the fineness after bulk drug and auxiliary material crossed 80 mesh sieve just has It is beneficial to mix uniformly; then each auxiliary material is dried separately, then cooled to room temperature, then each auxiliary material is mixed with the cefaclor bulk drug in a three-dimensional mixer, and finally the mixed material can be directly compressed into tablets. The preparation of cefaclor of the present invention The method of Luo dispersible table...

Embodiment 1

[0030] Weigh 125g of raw material cefaclor, 290g of microcrystalline cellulose, 30g of sodium starch glycolate, 15g of micropowder silica gel, 20g of talcum powder, and 5g of magnesium stearate as auxiliary materials, and pass through 80-mesh sieve respectively; Dry and pretreat in an oven for 4 hours, control the moisture content below 2% and cool to room temperature; fully mix the pretreated excipients and cefaclor raw material in a three-dimensional mixer for 40 minutes, and then directly compress into tablets, and prepare 1000 tablets in total .

Embodiment 2

[0032] Take by weighing 250g of raw material cefaclor, 210g of microcrystalline cellulose, 26g of sodium starch glycolate, 15g of micropowder silica gel, 15g of talcum powder, and 2.5g of magnesium stearate as auxiliary materials; respectively pass through a 80-mesh sieve. Dry and pretreat the excipients in an oven at 50-70°C for 5 hours, keep the moisture below 2% and cool to room temperature; fully mix the pretreated excipients and cefaclor raw material in a three-dimensional mixer for 40 minutes, and directly Compression, a total of 1000 tablets were prepared.

[0033] The following is the comparison of the cefaclor dispersible tablet prepared by the dry direct compression method of the present invention and the cefaclor dispersible tablet prepared by the traditional wet granulation tabletting method.

[0034] Table 1: Effect of preparation process on cefaclor dispersible tablets

[0035] Preparation

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Abstract

The invention relates to the field of medicinal preparations, in particular to a method for preparing cefaclor dispersible tablets by dry method direct tablet compressing and cefaclor dispersible tablets prepared by the same. The method comprises the following steps of: firstly, respectively sieving cefaclor and various auxiliary materials by a sieve of 80 meshes for later use; then respectively drying the auxiliary materials and cooling to room temperature; and finally, mixing the dried and cooled auxiliary materials with the cefaclor and then directly pressing tablets. The method has less production working procedures, simple equipment, short period and smaller medicament loss. The cefaclor dispersible tablets prepared by the dry method direct tablet compressing have quick disintegration and high stability.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a method for preparing cefaclor dispersible tablets by dry direct compression and the cefaclor dispersible tablets prepared by the method. Background technique [0002] Compared with ordinary tablets and capsules, Cefaclor Dispersible Tablets have the advantages of convenient administration, faster absorption, earlier onset of action, and higher bioavailability, and are especially suitable for children and the elderly. [0003] At present, the production of cefaclor dispersible tablets in my country adopts the process of wet granulation and tabletting. After mixing the drug and auxiliary materials, adding a binder to make a soft material, and then granulating, drying, mixing, and then tabletting. But its process step is more, and cycle is long, and medicine loss is bigger, because need the process of high-temperature drying in this process, have influence on the stabilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/545A61K47/38A61P31/04
Inventor 宋礼华王荣海倪晓燕储成风
Owner ANHUI ANKE BIOTECHNOLOGY (GRP) CO LTD
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