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Bile duct support and preparation method thereof

A bile duct stent and bile duct technology, applied in the field of medical devices, can solve problems such as bile duct narrowing, achieve the effects of reducing obstruction, avoiding re-stenosis, and improving biocompatibility

Inactive Publication Date: 2012-01-04
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned existing problems, the purpose of the present invention is to solve the defects existing in the existing medical alloy wire braided mesh bile duct stent, and to provide a method that can not only ensure the inherent high elasticity of the bile duct stent, but also reduce the impact of the bile duct stent on the inner wall of the bile duct stent. The hindering effect and the elastic force of the radial expansion of the stent stimulate the formation of bile duct endothelial cells and bile duct smooth muscle cells, a bile duct stent with a new structure that avoids re-narrowing of the bile duct and its preparation method

Method used

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  • Bile duct support and preparation method thereof
  • Bile duct support and preparation method thereof
  • Bile duct support and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]a Polyurethane electrospinning liquid preparation, weigh medical polyether polyurethane and add N,N-dimethylformamide, stir at room temperature 15°C for 5 hours to obtain medical polyether polyurethane concentration percentage of 3wt% uniform static electricity spinning solution;

[0043] b Electrospinning non-woven bile duct intima 3 preparation, inhale the spinning solution prepared in step a into the spinning solution tube for electrospinning, use a stainless steel rod with a diameter equal to the inner diameter of the mesh bile duct stent as a mold rod to collect the electrospinning , the stainless steel rod is well grounded and connected to the adjustable speed motor shaft at the same time, adjust the rotation speed of the speed control motor so that the rotation speed of the stainless steel mold rod is 50 rpm, the electrospinning high voltage power supply outputs a voltage of 5kV, and the nozzle of the spinning liquid pipe The vertical distance between the rod and ...

Embodiment 2

[0048] a preparation of polyurethane electrospinning liquid, taking medical polyester polyurethane and adding it into tetrahydrofuran, stirring at room temperature 20° C. for 8 hours to obtain a uniform electrospinning liquid whose concentration percentage of medical polyester polyurethane is 10 wt %;

[0049] b Electrospinning non-woven bile duct intima 3 preparation, inhale the spinning solution prepared in step a into the spinning solution tube for electrospinning, use a stainless steel rod with a diameter equal to the inner diameter of the mesh bile duct stent as a mold rod to collect the electrospinning , the stainless steel rod is well grounded and connected to the adjustable speed motor shaft at the same time, adjust the rotation speed of the speed control motor so that the rotation speed of the stainless steel mold rod is 1000 rpm, the electrospinning high voltage power supply outputs a voltage of 15kV, and the nozzle of the spinning liquid pipe The vertical distance to...

Embodiment 3

[0054] a preparation of polyurethane electrospinning solution, taking medical polycarbonate polyurethane and adding it into tetrahydrofuran, stirring at room temperature 20°C for 8 hours, obtaining a uniform electrospinning solution with a medical polyurethane concentration percentage of 15wt%;

[0055] b Electrospinning non-woven bile duct intima 3 preparation, inhale the spinning solution prepared in step a into the spinning solution tube for electrospinning, and use an aluminum rod with a diameter equal to the inner diameter of the mesh bile duct stent as a mold rod to collect the electrospun fibers , the aluminum rod is well grounded and connected to the adjustable speed motor shaft at the same time, adjust the rotation speed of the speed control motor so that the rotation speed of the aluminum mold rod is 2000 rpm, the electrospinning high voltage power supply outputs a voltage of 30kV, and the nozzle of the spinning liquid pipe The vertical distance to the aluminum rod is...

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Abstract

The invention relates to a bile duct support and a preparation method thereof. The bile duct support is characterized in that non-woven films are electrostatically spinned on the inner wall and the outer wall of a meshy bile duct support knitted by using the present medical alloy silk to form a cladding structure for an alloy silk meshy bile duct support. Because the film adopts medical polyurethane with favorable biocompatibility and high elasticity, the biocompatibility of the bile duct support in the body is improved, and the high elasticity of the support is maintained. A function of hindering the bile flowing through the bile duct by the support alloy silk and stimulation to bile duct endothelial cells and bile duct smooth muscle cells in the bile duct caused by radially expanding the bile duct by the alloy silk are effectively eliminated, and the bile duct is avoided to become narrow again. The bile duct support has simple preparation method, convenient operation, low cost and favorable controllability on preparation of the inner film and the outer film of the bile duct, and the method is suitable for preparing bile ducts with various diameters and lengths.

Description

technical field [0001] The invention relates to a medical device, more specifically to a bile duct expansion stent for treating bile duct stenosis or bile duct blockage and a preparation method thereof, belonging to the scope of medical devices. Background technique [0002] In 1985, Carrasco invented the first metal expansion stent for bile duct (AJR Am JRoentgenol. 1985; 145(6): 1279-1281), which achieved good therapeutic effect. This technology was gradually introduced in my country in the 1990s. Ordinary metal expandable stents are less traumatic when used in bile duct drainage. A stent with a larger diameter can be directly implanted with a delivery tube with a smaller diameter. After being placed in the narrow bile duct, it can be expanded to The original diameter produces a continuous expansion force on the narrow tube wall, thereby maintaining the stability of the ordinary metal expansion stent and making it difficult to move. [0003] The mesh bile duct stent braide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/90A61L31/10A61L31/02
Inventor 柏自奎陈立波徐卫林崔卫钢叶汶祥杨红军许杰沈小林黄菁菁李文斌
Owner WUHAN TEXTILE UNIV
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