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Method for measuring ciclopirox olamine

A technology of ciclopirox olamine and acetonitrile, which is applied in the field of analytical chemistry and can solve problems such as the unsuccessful detection of ciclopirox olamine

Inactive Publication Date: 2010-06-23
LANZHOU UNIVERSITY
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  • Abstract
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Problems solved by technology

However, even after such a long washout, this method still failed to detect ciclopirox olamine

Method used

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  • Method for measuring ciclopirox olamine
  • Method for measuring ciclopirox olamine
  • Method for measuring ciclopirox olamine

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Embodiment Construction

[0026] The present invention adopts Varian high-performance liquid chromatography (including ProStar 210 pump, 7725i sampling valve is 20 μ L sampling loop, ultraviolet detector is ProStar325, chromatographic data analysis system is StarWS) and AE.LICHROM C18 5 μ m 150 × 4.6 mm chromatographic column;

[0027] A method for measuring ciclopirox olamine, its implementation process is divided into the following four steps:

[0028] a. Preparation of ciclopirox olamine standard solution

[0029] Take 5.0 mg of ciclopirox olamine standard substance, and dilute it in a 5 mL volumetric flask with acetonitrile to obtain a 1 mg / mL stock solution; pipette volumes of 1.55 μL, 3.15 μL, 6.25 μL, 12.50 μL, 25.00 μL, 50.00 μL, respectively μL, 100.00μL, 250.005μL, 375.00μL stock solutions were diluted with acetonitrile to solutions with concentrations of 0.31ppm, 0.63ppm, 1.25ppm, 2.50ppm, 5.00ppm, 10.00ppm, 20.00ppm, 50.00ppm, 75.00ppm respectively. Then the above standard solution was irr...

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Abstract

The invention discloses a method for measuring ciclopirox olamine. A chromatographic column with C18 hydrophilic filler is selected, the clathration of beta-cyclodextrin on ciclopirox olamine is utilized, blended solution of aqueous solution of beta-cyclodextrin and acetonitrile is used as a mobile phase, an ultraviolet detector is adopted, and the method can be used for quantitatively measuring active ingredient ciclopirox olamine in a ciclopirox olamine emulsifiable paste. The method has low detection limit and wide linear range; and the linear range well covers the medicament concentration range of the ciclopirox olamine, so that the method can be well used for fast detection of the ciclopirox olamine in the medicament production process and clinical medicament monitoring.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and relates to a method for determining ciclopirox amine, more specifically, a high-efficiency solution for determining ciclopirox amine in ciclopirox amine cream through cyclodextrin inclusion ciclopirox amine Phase chromatography method. Background technique [0002] Ciclopirox olamine is also known as ciclopiroxamide and ciclopiroxamide. Molecular formula is C 14 h 24 N 2 o 3 , its structural formula is as follows: [0003] [0004] The molecular weight is 268.36. It has the characteristics of low toxicity and strong serum penetration. It has a strong sterilizing effect on skin fungi and Candida albicans, and has a good effect on treating skin keratinization diseases caused by fungi. When its concentration is 4-8 μg / ml, it can inhibit skin fungus and yeast, and at a higher concentration (16-78 μg / ml), it can also inhibit Escherichia coli, Proteus, Staphylococcus aureus, hemolytic s...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N1/34
Inventor 张海霞袁圣柳祝新月
Owner LANZHOU UNIVERSITY
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