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Preparation method and pharmaceutical uses of curcumin and pidotimod composition

A technology of curcumin and composition, applied in the directions of drug combination, medical preparation containing active ingredients, antitumor drug, etc., can solve the problems that the effect is not as good as that of curcumin, and curcumin's antipyretic and analgesic effect is not strong.

Inactive Publication Date: 2010-07-07
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antipyretic and analgesic effect of curcumin is not strong, it has no obvious stimulation to the stomach, and has no effect on the cardiovascular and central nervous system. Other curcumin homologues also have certain anti-inflammatory activities, but the effect is not as good as curcumin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Capsules

[0017] Pidotimod 400g

[0018] Curcumin 400g

[0019] Lysine 100g

[0020] Microcrystalline Cellulose 50g

[0021] Sodium Lauryl Sulfate 4g

[0022] Low-substituted hydroxypropyl cellulose 50g

[0023] Made into 2000 capsules

[0024] Preparation method: Weigh the prescribed amount of pidotimod, curcumin, lysine, microcrystalline cellulose, sodium dodecyl sulfonate, and low-substituted hydroxypropyl cellulose, pass through a 60-mesh sieve, mix evenly, and fill the capsules. Can.

Embodiment 2

[0025] Embodiment 2: tablet

[0026] Prescription: Pidotimod 400g

[0027] Curcumin 400g

[0028] Lysine 100g

[0029] Microcrystalline Cellulose 50g

[0030] Sodium dodecyl sulfonate 5g

[0031] Low-substituted hydroxypropyl cellulose 50g

[0032] Made into 2000 capsules

[0033] Preparation method: Weigh the prescribed amount of pidotimod, curcumin, lysine, microcrystalline cellulose, sodium dodecyl sulfonate, and low-substituted hydroxypropyl cellulose, pass through a 60-mesh sieve, mix evenly, and dry-press into tablets , film-coated, and that’s it.

Embodiment 3

[0034] Embodiment 3: dispersible tablet

[0035] Prescription: Pidotimod 400g

[0036] Curcumin 500g

[0037] Microcrystalline Cellulose 100g

[0038] Arginine 50g

[0039] Crospovidone 80g

[0040] Mannitol 100g

[0041] Aspartame 5g

[0042] 5% povidone K30 (40% ethanol) solution appropriate amount

[0043] Sodium dodecyl sulfonate 5.5g

[0044] Makes 1000 pieces

[0045] Preparation method: get prescription amount of pidotimod, curcumin, microcrystalline cellulose, arginine, crospovidone, mannitol and pass through 80 mesh sieve and mix evenly, add 5% povidone K30 (40% ethanol ) solution, stir to make soft material, pass through a 20-mesh sieve to granulate, dry in an oven at 60°C for 1 hour, add sodium dodecylsulfonate, and granulate with a 20-mesh sieve. Pressing, film-coating, packaging, ready to use.

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PUM

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Abstract

The invention discloses a preparation method and pharmaceutical uses of a curcumin and pidotimod composition. The curcumin and pidotimod composition is used for treating: (1) recurrent upper and lower respiratory tract infections (pharyngitis, tracheitis, bronchitis and tonsillitis); (2) ENT recurrent infections (rhinitis, sinusitis and otitis); (3) urinary system infection; (4) gynecological infection; (5) clinical patients with low cellular immune function after chemotherapy; and (6) specific and non-specific immune deficiency diseases such as cancer and the like. The curcumin and pidotimod composition can be used for reducing the number of acute attack, shortening the course of medication and reducing the degree of attack, and also can be used for the adjuvant treatment of antibiotics during acute infection. The pidotimod and curcumin composition together with various pharmaceutically acceptable excipients are comprised, and various pharmaceutically acceptable dosage forms can be prepared, including but not limited to tablets, capsules, injection agents and the like.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to the preparation and pharmaceutical use of curcumin and pidotimod composition, which is used for the treatment of ① recurrent upper and lower respiratory tract infections (pharyngitis, tracheitis, bronchitis, tonsillitis); ② ENT Department of repeated infection (rhinitis, sinusitis, otitis); ③ urinary system infection; ④ gynecological infection; ⑤ clinical patients with low cellular immune function after chemotherapy; ⑥ specific and non-specific immune deficiency diseases such as cancer. It is used to reduce the number of acute attacks, shorten the course of the disease, and reduce the degree of attacks; it can also be used as an adjuvant treatment of antibiotics in acute infections. Specifically, it is a preparation method and medicinal application of curcumin and pidotimod composition. Background technique [0002] The immune system of the human body is like a well-trained ...

Claims

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Application Information

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IPC IPC(8): A61K31/427A61K31/12A61P31/00A61P35/00
Inventor 王翰斌郑明月李彬彬
Owner BEIJING HOPE HUGE PHARM SCI
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