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Compound alpha-keto acid tablet and preparation method thereof

The technology of a ketoacid tablet and a compound formula is applied in the field of medicine, and can solve the problems of poor taste, poor stability, unpleasant smell and slight odor, and achieve the effects of simple preparation method, good stability and easy absorption.

Inactive Publication Date: 2010-07-14
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent application 200710163357 discloses a compound α-keto acid chewable tablet, but those skilled in the art know that compound α-keto acid is a kind of medicine with poor taste, even if it is made into a coated chewable tablet and chewed and pulverized in the mouth It will also produce a relatively unpleasant micro-odor, and at the same time, the long-term storage stability is poor

Method used

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  • Compound alpha-keto acid tablet and preparation method thereof
  • Compound alpha-keto acid tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] According to the following quality, prepare 1000 pieces of compound α-keto acid tablets

[0063] Calcium rac-Keto-Isoleucine 67g

[0064] Calcium Ketoleucine 101g

[0065] Calcium Ketophenylalanine 68g

[0066] Ketovaline Calcium 86g

[0067] Calcium R-Hydroxymethionine 59g

[0068] L-Lysine Acetate 105g

[0069] L-Threonine 53g

[0070] L-Tryptophan 23g

[0071] L-histidine 38g

[0072] L-Tyrosine 30g

[0073] Microcrystalline Cellulose 40g

[0074] Croscarmellose Sodium 50g

[0075] Povidone K30 10g

[0076] Magnesium Stearate 5g

[0077] Micronized silica gel 5g

[0078] Coating powder YCW 20g

[0079] Purified water 150g

[0080] Preparation:

[0081] Each raw medicinal material is passed through a 100-mesh sieve respectively, and is set aside. Weigh povidone K30, slowly add it into an appropriate amount of water under stirring, and stir to dissolve.

[0082] Take by weighing the cross-linked sodium carboxymethyl cellulose of each principal agent that...

Embodiment 2

[0087] According to the following quality, prepare 1000 pieces of compound α-keto acid tablets

[0088] Calcium rac-Keto-Isoleucine 67g

[0089] Calcium Ketoleucine 101g

[0090] Calcium Ketophenylalanine 68g

[0091] Ketovaline Calcium 86g

[0092] Calcium R-Hydroxymethionine 59g

[0093] L-Lysine Acetate 105g

[0094] L-Threonine 53g

[0095] L-Tryptophan 23g

[0096] L-histidine 38g

[0097] L-Tyrosine 30g

[0098] Microcrystalline Cellulose 80g

[0099] Croscarmellose Sodium 200g

[0100] Povidone K30 50g

[0101] Magnesium Stearate 30g

[0102] Micronized silica gel 20g

[0103] Coating powder YCW 50g

[0104] Purified water 400g

[0105] Preparation:

[0106] Each raw medicinal material is passed through a 100-mesh sieve respectively, and is set aside. Weigh povidone K30, slowly add it into an appropriate amount of water under stirring, and stir to dissolve.

[0107] Take by weighing each principal agent that has pretreated, adjuvant microcrystalline cel...

Embodiment 3

[0112] According to the following quality, prepare 1000 pieces of compound α-keto acid tablets

[0113] Calcium rac-Keto-Isoleucine 67g

[0114] Calcium Ketoleucine 101g

[0115] Calcium Ketophenylalanine 68g

[0116] Ketovaline Calcium 86g

[0117] Calcium R-Hydroxymethionine 59g

[0118] L-Lysine Acetate 105g

[0119] L-Threonine 53g

[0120] L-Tryptophan 23g

[0121] L-histidine 38g

[0122] L-Tyrosine 30g

[0123] Microcrystalline Cellulose 70g

[0124] Croscarmellose Sodium 120g

[0125] Povidone K30 30g

[0126] Magnesium Stearate 20g

[0127] Micronized silica gel 20g

[0128] Coating powder YCW 30g

[0129] Purified water 250g

[0130] Preparation:

[0131] Each raw medicinal material is passed through a 100-mesh sieve respectively, and is set aside. Weigh povidone K30, slowly add it into an appropriate amount of water under stirring, and stir to dissolve.

[0132] Take by weighing the cross-linked sodium carboxymethyl cellulose of each principal agent...

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Abstract

The invention discloses a compound alpha-keto acid tablet, which comprises five amino acids and five keto acid calcium salts. By improving auxiliary materials, the tablet improves the disintegration time and the stability and overcomes unpleasant odor of the existing tablet. Simultaneously, the invention further discloses a preparation method of the tablet.

Description

technical field [0001] The invention discloses a compound alpha-keto acid tablet and a preparation method thereof, belonging to the field of medicine. Background technique [0002] In modern society, the incidence of chronic kidney disease is increasing day by day in recent years, and a large part of patients with chronic kidney disease will eventually deteriorate into uremia, which will bring a heavy economic burden to patients, families and society. Drugs for the treatment of chronic kidney disease have attracted widespread attention. [0003] The compound α-ketoacid preparation is a drug that has been successfully used clinically in the past ten years. It is a compound preparation containing 4 kinds of ketoamino acid calcium, 1 kind of hydroxyamino acid calcium and 5 kinds of amino acids. It can increase glomerular filtration and The excretion of urinary albumin is mainly used to delay the progress of renal failure, correct metabolic disorders, prevent and treat damage c...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61K31/19A61K31/192A61K31/205A61K31/198A61K31/405A61K9/28A61P13/12
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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