Compound alpha-keto acid tablet and preparation method thereof

The technology of a ketoacid tablet and a compound formula is applied in the field of medicine, and can solve the problems of poor taste, poor stability, unpleasant smell and slight odor, and achieve the effects of simple preparation method, good stability and easy absorption.

Inactive Publication Date: 2010-07-14

BEIJING CENTURY BIOCOM PHARMA TECH

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AI-Extracted Technical Summary

Problems solved by technology

[0005] Chinese patent application 200710163357 discloses a compound α-keto acid chewable tablet, but those skilled in the art know that compound α-keto acid is a kind of medicine with poor taste, even ...

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Abstract

The invention discloses a compound alpha-keto acid tablet, which comprises five amino acids and five keto acid calcium salts. By improving auxiliary materials, the tablet improves the disintegration time and the stability and overcomes unpleasant odor of the existing tablet. Simultaneously, the invention further discloses a preparation method of the tablet.

Application Domain

Urinary disorderAnhydride/acid/halide active ingredients +1

Technology Topic

ChemistryAmino acid +3

Image

Examples

Experimental program(3)
Comparison scheme(2)
Effect test(1)

Example Embodiment

[0061] Example 1

[0062] According to the following quality, prepare 1000 compound α-keto acid tablets

[0063] Calcium ketone isoleucine 67g

[0064] Calcium Ketoleucine 101g

[0065] Calcium Ketophenylalanine 68g

[0066] Ketovaline calcium 86g

[0067] Calcium racemic hydroxymethionine 59g

[0068] L-Lysine Acetate 105g

[0069] L-threonine 53g

[0070] L-tryptophan 23g

[0071] L-histidine 38g

[0072] L-tyrosine 30g

[0073] Microcrystalline cellulose 40g

[0074] Croscarmellose Sodium 50g

[0075] Povidone K30 10g

[0076] Magnesium stearate 5g

[0077] Micronized silica gel 5g

[0078] Coating powder YCW 20g

[0079] Purified water 150g

[0080] Preparation:

[0081] Each raw material is passed through a 100-mesh sieve and set aside. Weigh povidone K30, slowly add it to an appropriate amount of water under stirring, and stir to dissolve.

[0082] Weigh each pretreated main drug, auxiliary material microcrystalline cellulose, and 20 g of croscarmellose sodium according to the prescription.

[0083] Each main drug and auxiliary materials, microcrystalline cellulose, and 20 g of croscarmellose sodium are mixed uniformly, and the povidone K30 aqueous solution is added and mixed to make wet granules.

[0084] The wet granules are placed in a boiling dryer and air-dried at 45°C. After the dry granules are sized through a 20-mesh sieve, the remaining prescription amount of croscarmellose sodium, magnesium stearate, and micronized silica gel are added to mix for total mixing and tableting.

[0085] Weigh the coating powder according to the prescription, add water to dissolve it, and stir well for use. Place the compressed tablet cores in a high-efficiency coating machine for coating.

Example Embodiment

[0086] Example 2

[0087] According to the following quality, prepare 1000 compound α-keto acid tablets

[0088] Calcium ketone isoleucine 67g

[0089] Calcium Ketoleucine 101g

[0090] Calcium Ketophenylalanine 68g

[0091] Ketovaline calcium 86g

[0092] Calcium racemic hydroxymethionine 59g

[0093] L-Lysine Acetate 105g

[0094] L-threonine 53g

[0095] L-tryptophan 23g

[0096] L-histidine 38g

[0097] L-tyrosine 30g

[0098] Microcrystalline cellulose 80g

[0099] Sodium Croscarmellose 200g

[0100] Povidone K30 50g

[0101] Magnesium stearate 30g

[0102] Micronized silica gel 20g

[0103] Coating powder YCW 50g

[0104] Purified water 400g

[0105] Preparation:

[0106] Each raw material is passed through a 100-mesh sieve and set aside. Weigh povidone K30, slowly add it to an appropriate amount of water under stirring, and stir to dissolve.

[0107] Weigh each pretreated main drug, auxiliary material microcrystalline cellulose, and 100 g of croscarmellose sodium according to the prescription.

[0108] Each main medicine and auxiliary materials, microcrystalline cellulose, and 80 g of croscarmellose sodium are mixed uniformly, and the povidone K30 aqueous solution is added and mixed to make wet granules.

[0109] The wet granules are placed in a boiling dryer and dried by blowing at 40°C, and the obtained granules are white. After the dry granules are sized through a 20-mesh sieve, the remaining prescription amount of croscarmellose sodium, magnesium stearate, and micronized silica gel are added to mix for total mixing and tableting.

[0110] Weigh the coating powder according to the prescription, add water to dissolve it, and stir well for use. Place the compressed tablet cores in a high-efficiency coating machine for coating.

Example Embodiment

[0111] Example 3

[0112] According to the following quality, prepare 1000 compound α-keto acid tablets

[0113] Calcium ketone isoleucine 67g

[0114] Calcium Ketoleucine 101g

[0115] Calcium Ketophenylalanine 68g

[0116] Ketovaline calcium 86g

[0117] Calcium racemic hydroxymethionine 59g

[0118] L-Lysine Acetate 105g

[0119] L-threonine 53g

[0120] L-tryptophan 23g

[0121] L-histidine 38g

[0122] L-tyrosine 30g

[0123] Microcrystalline cellulose 70g

[0124] Croscarmellose Sodium 120g

[0125] Povidone K30 30g

[0126] Magnesium stearate 20g

[0127] Micronized silica gel 20g

[0128] Coating powder YCW 30g

[0129] Purified water 250g

[0130] Preparation:

[0131] Each raw material is passed through a 100-mesh sieve and set aside. Weigh povidone K30, slowly add it to an appropriate amount of water under stirring, and stir to dissolve.

[0132] Weigh each pretreated main drug, auxiliary material microcrystalline cellulose, and 80 g of croscarmellose sodium according to the prescription.

[0133] Each main medicine and auxiliary materials, microcrystalline cellulose, and 80 g of croscarmellose sodium are mixed uniformly, and the povidone K30 aqueous solution is added and mixed to make wet granules.

[0134] The wet granules are placed in a boiling dryer and dried by blowing at 40°C, and the obtained granules are white. After the dry granules are sized through a 20-mesh sieve, the remaining prescription amount of croscarmellose sodium and magnesium stearate are mixed for total mixing and tableting.

[0135] Weigh the coating powder according to the prescription, add water to dissolve it, and stir well for use. Place the compressed tablet cores in a high-efficiency coating machine for coating.

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Description & Claims & Application Information

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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

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