Compound alpha-keto acid tablet and preparation method thereof

The technology of a ketoacid tablet and a compound formula is applied in the field of medicine, and can solve the problems of poor taste, poor stability, unpleasant smell and slight odor, and achieve the effects of simple preparation method, good stability and easy absorption.

Inactive Publication Date: 2010-07-14
BEIJING CENTURY BIOCOM PHARMA TECH
View PDF1 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent application 200710163357 discloses a compound α-keto acid chewable tablet, but those skilled in the art know that compound α-keto acid is a kind of medicine with poor taste, even

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound alpha-keto acid tablet and preparation method thereof
  • Compound alpha-keto acid tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0061] Example 1

[0062] According to the following quality, prepare 1000 compound α-keto acid tablets

[0063] Calcium ketone isoleucine 67g

[0064] Calcium Ketoleucine 101g

[0065] Calcium Ketophenylalanine 68g

[0066] Ketovaline calcium 86g

[0067] Calcium racemic hydroxymethionine 59g

[0068] L-Lysine Acetate 105g

[0069] L-threonine 53g

[0070] L-tryptophan 23g

[0071] L-histidine 38g

[0072] L-tyrosine 30g

[0073] Microcrystalline cellulose 40g

[0074] Croscarmellose Sodium 50g

[0075] Povidone K30 10g

[0076] Magnesium stearate 5g

[0077] Micronized silica gel 5g

[0078] Coating powder YCW 20g

[0079] Purified water 150g

[0080] Preparation:

[0081] Each raw material is passed through a 100-mesh sieve and set aside. Weigh povidone K30, slowly add it to an appropriate amount of water under stirring, and stir to dissolve.

[0082] Weigh each pretreated main drug, auxiliary material microcrystalline cellulose, and 20 g of croscarmellose sodium according to the prescription.

[00...

Example Embodiment

[0086] Example 2

[0087] According to the following quality, prepare 1000 compound α-keto acid tablets

[0088] Calcium ketone isoleucine 67g

[0089] Calcium Ketoleucine 101g

[0090] Calcium Ketophenylalanine 68g

[0091] Ketovaline calcium 86g

[0092] Calcium racemic hydroxymethionine 59g

[0093] L-Lysine Acetate 105g

[0094] L-threonine 53g

[0095] L-tryptophan 23g

[0096] L-histidine 38g

[0097] L-tyrosine 30g

[0098] Microcrystalline cellulose 80g

[0099] Sodium Croscarmellose 200g

[0100] Povidone K30 50g

[0101] Magnesium stearate 30g

[0102] Micronized silica gel 20g

[0103] Coating powder YCW 50g

[0104] Purified water 400g

[0105] Preparation:

[0106] Each raw material is passed through a 100-mesh sieve and set aside. Weigh povidone K30, slowly add it to an appropriate amount of water under stirring, and stir to dissolve.

[0107] Weigh each pretreated main drug, auxiliary material microcrystalline cellulose, and 100 g of croscarmellose sodium according to the prescription. ...

Example Embodiment

[0111] Example 3

[0112] According to the following quality, prepare 1000 compound α-keto acid tablets

[0113] Calcium ketone isoleucine 67g

[0114] Calcium Ketoleucine 101g

[0115] Calcium Ketophenylalanine 68g

[0116] Ketovaline calcium 86g

[0117] Calcium racemic hydroxymethionine 59g

[0118] L-Lysine Acetate 105g

[0119] L-threonine 53g

[0120] L-tryptophan 23g

[0121] L-histidine 38g

[0122] L-tyrosine 30g

[0123] Microcrystalline cellulose 70g

[0124] Croscarmellose Sodium 120g

[0125] Povidone K30 30g

[0126] Magnesium stearate 20g

[0127] Micronized silica gel 20g

[0128] Coating powder YCW 30g

[0129] Purified water 250g

[0130] Preparation:

[0131] Each raw material is passed through a 100-mesh sieve and set aside. Weigh povidone K30, slowly add it to an appropriate amount of water under stirring, and stir to dissolve.

[0132] Weigh each pretreated main drug, auxiliary material microcrystalline cellulose, and 80 g of croscarmellose sodium according to the prescription.

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a compound alpha-keto acid tablet, which comprises five amino acids and five keto acid calcium salts. By improving auxiliary materials, the tablet improves the disintegration time and the stability and overcomes unpleasant odor of the existing tablet. Simultaneously, the invention further discloses a preparation method of the tablet.

Description

technical field [0001] The invention discloses a compound alpha-keto acid tablet and a preparation method thereof, belonging to the field of medicine. Background technique [0002] In modern society, the incidence of chronic kidney disease is increasing day by day in recent years, and a large part of patients with chronic kidney disease will eventually deteriorate into uremia, which will bring a heavy economic burden to patients, families and society. Drugs for the treatment of chronic kidney disease have attracted widespread attention. [0003] The compound α-ketoacid preparation is a drug that has been successfully used clinically in the past ten years. It is a compound preparation containing 4 kinds of ketoamino acid calcium, 1 kind of hydroxyamino acid calcium and 5 kinds of amino acids. It can increase glomerular filtration and The excretion of urinary albumin is mainly used to delay the progress of renal failure, correct metabolic disorders, prevent and treat damage c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4172A61K31/19A61K31/192A61K31/205A61K31/198A61K31/405A61K9/28A61P13/12
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap